DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and gcy-36

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_510557.3	Gene:	gcy-36 / 191657	WormBaseID:	WBGene00001556	Length:	675	Species:	Caenorhabditis elegans

Alignment Length:	717	Identity:	186/717 - (25%)
Similarity:	279/717 - (38%)	Gaps:	225/717 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   419 YTVITLQNDVGSGASIGSLAKMSMQPVGFF-------------AYDKNSVIPEFRYIKNDRP--- 467
            ||:.|..:|:        :..||....||.             .|..|...|.||.  .|.|
Worm    77 YTMETGWDDL--------IRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRC--EDNPDGT 131

  Fly   468 --IQWLNGRPPLAEPLCGFHGELCPRK-KLDWRYLVSGPLCALVVVVA-------IALLIKHYRY 522
              :.:..|||.|...:.|...|...|. |||....::|.....|.:..       :..|:|....
Worm   132 ITLHYYTGRPGLYPIVKGVLREAAKRVFKLDVSMTITGRTQRSVQMATGERIEEHVIFLVKTLNT 196

  Fly   523 EQTLAGLL----------WKVDMKDVTVINLGEYNNPTNKN--IFQICRQ-------SILVVGEP 568
            :|:....|          :|:.:..:..|:...|:...:::  |.|:.|:       .:|.||.|
Worm   197 DQSNEEALGTAVVQHSNNYKIRLTHMDFISTFPYHMVVDQDCKIVQVGRELYNHIPKDLLSVGTP 261

  Fly   569 NKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVII--- 630
            ..|.|                     ::|   |.::.|    ..::|.|||.|      |.:
Worm   262 LMRIF---------------------EVT---RPQIPL----DFDSICNFINA------VFVLQV 292

  Fly   631 ------FTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLID 689
                  |.....:.:.:.:.|:|:|:.|:           .|.:.|..|:   |..|:....|:.
Worm   293 KTTPMEFQRNANKRAAQAIEASENLYEDN-----------NGALALSQSQ---HLKLKGQMMLMS 343

  Fly   690 SRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEM 754
            |         |.|.:                .||
Worm   344 S---------GGHIM----------------YLC------------------------------- 352

  Fly   755 IGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDI 819
                .|:            ....||:||:|     |..|.:.|             .|| .|..|
Worm   353 ----SPY------------VTSIPELLQYG-----LRLTAMPI-------------HDP-TRDLI 382

  Fly   820 RLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAE 884
            .|.:..|.:::..|:          :|.....||.:.::    |..||.|||.||.:|||..||:
Worm   383 LLNQQRLSDVEMNLQ----------LEANNEQLENMAKD----LEVEKGKTDALLREMLPPSVAQ 433

  Fly   885 LLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIG 949
            .||:|..|||..::..|::|:|:..|.::....||.::|.:||:.:|..|.:|.....|||||:|
Worm   434 QLKQGLSVEAREYEEATVMFTDVPTFQQIVPLCTPKDIVHLLNELFTKFDRLIGIQKAYKVETVG 498

  Fly   950 DAYMVVSGLPLQNGSRHAGEIASLALHLL---ETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVG 1011
            |:||.|.|:| .....|...|..|||.::   .||.: .|.:.|   :.:|.|:||||..|||||
Worm   499 DSYMSVGGIP-DLVDDHCEVICHLALGMVMEARTVCD-PITNTP---LHIRAGIHSGPVVAGVVG 558

  Fly  1012 QKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076
            .||||||||||||||:|||||.....|||.||...:..:..|.:....||...|||||:|.||:|
Worm   559 AKMPRYCLFGDTVNTSSRMESHSPIGRIHCSENAKKCAESTGRFEFEPRGRVQIKGKGEMNTYFL 623

  Fly  1077 TK 1078
            .:
Worm   624 LR 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	7/28 (25%)
		ANF_receptor	59..427	CDD:279440	3/7 (43%)
		PHA02988	534..826	CDD:165291	50/309 (16%)
		PK_GC-A_B	550..832	CDD:270944	49/299 (16%)
		HNOBA	<847..886	CDD:285003	15/38 (39%)
		CYCc	865..1057	CDD:214485	87/194 (45%)
		Guanylate_cyc	892..1076	CDD:278633	82/186 (44%)
gcy-36	NP_510557.3	HNOB	3..167	CDD:285002	25/99 (25%)
		HNOBA	217..435	CDD:285003	68/370 (18%)
		CYCc	415..604	CDD:214485	87/193 (45%)
		Guanylate_cyc	441..624	CDD:278633	82/187 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810