DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and gcy-27

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001255957.2	Gene:	gcy-27 / 191654	WormBaseID:	WBGene00001550	Length:	616	Species:	Caenorhabditis elegans

Alignment Length:	621	Identity:	204/621 - (32%)
Similarity:	317/621 - (51%)	Gaps:	78/621 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 LVVVVAIALLIKHYRYEQTLAG-------LLWKVDMKDVTVINLGEYNNPTNKNI---FQICRQS 561
            :.|:...:..:.::.|| |:.|       :.|||..:.:.:|        .|||.   .|...::
Worm     5 ITVIRDFSYSVYNWCYE-TVIGENTRKYKMTWKVPKESLKII--------VNKNADARMQRELEN 60

  Fly   562 ILVVGEPN-----KRSFTNIALF---RGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINF 618
            .....|.|     :|.|.:.||.   |...:..::|  |.:|||.:....|..:::::|:|:.||
Worm    61 RTAKDEANALTSRRRVFGSYALIGTQRAEFIQFRQI--KHIDITNASLDFLYNLKQLKHDNLANF 123

  Fly   619 IG--ASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNL 681
            .|  .:.|..::.|......||:||:...:.|..:|..|.|:.:.|||||:.|||.|.:..||:|
Worm   124 YGIQLNDDLNTMTILHALVERGTLEEFCLDRDFGMDETFKSAFMRDILKGLQYLHLSPVAYHGHL 188

  Fly   682 RSSNCLIDSRWVCQISDFGLHELKAGQEE------PNKSELELKRA--LCMAPELLRDAYRPG-- 736
            .::.||||..||.:|:.:|:........:      |::|:..:..|  :|..||.:|:....|
Worm   189 HAATCLIDINWVLKIALYGVTNFVCDNFDAENITMPDRSDYTISYAQYVCFPPEHIREYDATGKL 253

  Fly   737 -----RGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCP------EMLQHGVFRPAL 790
                 |||::||:|..|::.|.||.|:.|:        .:|..|:.|      |:|.|.:. |.:
Worm   254 PTRFVRGSKQGDIYCVGMIFYMMIEREDPY--------RLIHSVERPGSGLMMEILDHNLM-PFI 309

  Fly   791 THTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGL 855
            ::........:.||. :||:.|||.||.|..:|..:....|..|.|:.|.|:.:.||||..||.|
Worm   310 SNNETQEDTLLDKCK-ECWNRDPEKRPTIENLRNAIAICYADSKGNLIDQMIRMNEKYADELETL 373

  Fly   856 VQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPF 920
            |..|:..|...:.:|..||.:|||..:|:.||.|....|..:...|::|..|..|..:.....|.
Worm   374 VAARSADLALAQMQTMRLLNEMLPASIAKDLKNGVIAPARSYASATVMFVQICDFIVILKRRPPK 438

  Fly   921 EVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHL-------- 977
            ||:..|||.:...|::|..:|.|||||.|:.|||.||:|.:|..||..|:|.::|.:
Worm   439 EVIGFLNDIFDQFDTVIKRHDAYKVETTGETYMVASGVPNENEGRHVFEVAEMSLEIRAISLSYT 503

  Fly   978 LETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHIS 1042
            ||...|.|:|        :|||.|:||.||||:|.|.|||||||||||.||||:|....::|..|
Worm   504 LENDKNYKLR--------VRIGFHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCPPLQIQTS 560

  Fly  1043 EATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTK 1078
            |.|.::|.....|..::||:..:||||::..|||.:
Worm   561 EITARMLLATHEYKLVKRGIVHVKGKGEVNCYWLNE 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	91/325 (28%)
		PK_GC-A_B	550..832	CDD:270944	90/315 (29%)
		HNOBA	<847..886	CDD:285003	16/38 (42%)
		CYCc	865..1057	CDD:214485	81/199 (41%)
		Guanylate_cyc	892..1076	CDD:278633	78/191 (41%)
gcy-27	NP_001255957.2	PKc_like	75..338	CDD:304357	82/274 (30%)
		CYCc	383..573	CDD:214485	80/197 (41%)
		Guanylate_cyc	411..595	CDD:278633	79/191 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920