Protein Alignment Gyc32E and gcy-21

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001364740.1
• Gene: gcy-21 / 191651
• WormBaseID: WBGene00001546
• Length: 1163
• Species: Caenorhabditis elegans
• Alignment Length: 1118
• Identity: 361/1118 - (32%)
• Similarity: 543/1118 - (48%)
• Gaps: 152/1118 - (13%)

  Fly    62 LPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESCTTEAL 126
            :.:||..:|.:.:|     ..|..:|:.:..::....|..|.|.....|..|.:|....|..::.
 Worm    60 MEIAINRLNADKDL-----EVFHDLDVNYVDTSKTAGPRAARTAALNNGTIAALGLMRDCYIQST 119

  Fly   127 LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWG 191
            :.:..:...:|..|...:.|.|....|.....:..:.::|||:..|:.:.|.|.:: ||...:..
 Worm   120 ILNINSKIAVSDVCEMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQWKKVAL-VSPSTVLT 183

  Fly   192 SDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVR 256
            :...|...:|.:|  .|.:....:.|  .....:|.|...::|.....||:: |.:..:..:.:|
 Worm   184 AFATRVRSDLLDA--LTANKIDILVD--SRLDPMSDITDKVKEDAEKARIFI-ICDWSSNANLLR 243

  Fly   257 ------GLQNRRLLESGDYIVVSVDDEIYDSN----------RRVNIMERNYLDPYIRKEKSKSL 305
                  |..|:  ::||:|.|:....  ||:|          :|:..:..:.::.|...|  ..|
 Worm   244 NYLFKLGEMNK--MQSGEYFVLGYIS--YDTNYQWLEASSGDQRLVHLGASDINDYNLTE--NDL 302

  Fly   306 DKISFRSVIKISMTYP---QNPHIRDICSKI--KDYARKTPFLVPY-----HQRV---FDNISVP 357
            .:: :::|:.:|...|   .|....||.|::  |..|:..|   ||     .:::   :|.|.:
 Worm   303 HEV-YKNVVILSDGPPPAEPNSTWEDIKSQVLMKKPAKMCP---PYCNTTVSEKITPRWDRIKL- 362

  Fly   358 IYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVI 422
                 |:||:.....|..:.|.:|.:||..::...::.:|...|:.|...:||
 Worm   363 -----LFDSIQYLADATNDALNIGANIYQSDIFYEYLISRKIDSVTGVTEFID------------ 410

  Fly   423 TLQNDVGSGASIGSLA-----------KMSMQPVGFFAYDK--NSVIPEFRYIKNDRPIQWLNGR 474
                  |.||.:||:.           ..|:.|....|...  |:|.....| .....|.::|..
 Worm   411 ------GYGAIVGSIQIYYHFSSSSHNSYSLFPCARLAQSSLLNTVWSLTDY-SEGLSIDFVNKS 468

  Fly   475 PPLAEPLCGFHGELC-PRKKLDWRYLVSGPLCALV-VVVAIALLIKHYRYEQTLAGLLWKVDMKD 537
            .|...|:|||:||.| |.....:..::|..:..|: :.:|.|.|.|.||||:.|..|.:.:|...
 Worm   469 APKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYRYERRLHSLFFMIDRNQ 533

  Fly   538 VTV---INL------------------------------GEYNNPTNKNIFQICRQSIL------ 563
            :.:   .||                              .:|||.::.|...|......
 Worm   534 IILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASSINASSIFNTGSTARAGPF 598

  Fly   564 --------VVGEPNKRSFTNI-----ALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENI 615
                    |.|......:..|     .|:.|..||:|:|::..|:.|||||.|:..::|..:.|:
 Worm   599 GPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALKRIYRSDVEFTRSIRLEIAKLQESVNSNV 663

  Fly   616 INFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGN 680
            |.|:|.......|.:......||||:|:|.|:|:.||.:|.|.:..||:.|:.|||.|.|..||.
 Worm   664 IEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPIGCHGR 728

  Fly   681 LRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSEL-ELKRALCMAPELLRDAYRPGRGS----- 739
            |:|:|||||:||:.::|.|||.||:..:....:.:: |.|..|..:|||||  :..|...
 Worm   729 LKSTNCLIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLR--WSTGLSQCGVLL 791

  Fly   740 -QKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRK 803
             ||.||||..|:|||:.||.|||||......||:..||...:.....|||.:. ...:.|..:::
 Worm   792 VQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMA-VLKESPRIVQE 855

  Fly   804 CLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKK 868
            .:...|.|||..||.:..::..||.|..|||..|.|||:|::|||...||..:.||...|..||.
 Worm   856 TVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNEELEGEKA 920

  Fly   869 KTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCC 933
            |::.||..|||..||:.||.|..|.||.|:..|:.|||..||.|:..||.|.::|:.|||.||..
 Worm   921 KSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLNDLYTVF 985

  Fly   934 DSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRI 998
            |.||..:||||||||.|||||.||||:.||:.||||||||.|.||:.|.:.||||.|.|.|:|||
 Worm   986 DRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLPNEKVRLRI 1050

  Fly   999 GVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLT 1063
            |::||||.|||||.||||||||||||||||||||.|..:||:.|....::|..:|.|...|||:.
 Worm  1051 GMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYEIEERGIV 1115

  Fly  1064 SIKGKGDMRTYWL 1076
            .:||||...||::
 Worm  1116 EMKGKGKQMTYFV 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	85/425 (20%)
		PK_GC-A_B	550..832	CDD:270944	104/307 (34%)
		CYCc	865..1057	CDD:214485	114/191 (60%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:471960	83/406 (20%)
		PK_GC	612..881	CDD:270894	99/271 (37%)
		HNOBA	<890..938	CDD:462234	22/47 (47%)
		Guanylate_cyc	944..1130	CDD:425528	110/185 (59%)