DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and gcy-17

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	1169	Identity:	351/1169 - (30%)
Similarity:	535/1169 - (45%)	Gaps:	190/1169 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLLLGCQRSNPLAAG----ATVSSMRRLTDTINIGFLAEYSQMRVTLGGLPLAIEDVNKNPNLLP 77
            |:|..||....:..|    ..|||::     :.||:....:.:.||...:        :..::|.
Worm    13 LILANCQARRTIKVGLLFVQNVSSLQ-----VGIGYRTSAAAVLVTKNKI--------REDHVLD 64

  Fly    78 GKKLAF--------KPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESCTTEALLASA---- 130
            |....|        :.:..|..:....||.           |....||  :|:..||::||
Worm    65 GFDFEFLWDFDECNEILGAGKTVDLLEVKK-----------VDVIFGP--TCSRPALISSALATY 116

  Fly   131 WNTPMLSF-KCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSD- 193
            :|.|:..: ..|...:::...|.|.......:..::.:::..|..|.|.:|..:..:.   |.|
Worm   117 YNIPIFEWGLTSTRQLTDVKRFPTTLPFSVNSYSLAMAILGTLKQFQWTEFVFLYCND---GDDE 178

  Fly   194 -----------VARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFI-- 245
                       ||.|.:||:.|..|.|.           :|.|..:...|.|.....||.|..
Worm   179 KCESLKDDVQTVASAHEELSLAYTFRIQ-----------SKKLEDMRAAIVEIKKRGRIIVACVA 232

  Fly   246 ---GEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMER-----NYL--------D 294
               |....::..| .|:|   ..:.:|:.:     :.::|.|..::|.     :||        |
Worm   233 SGNGSKRTLMQAV-ALEN---ANNSEYVYI-----MAETNSRGFVVEEVGGKWHYLWEGKFDDSD 288

  Fly   295 PYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNI----- 354
            .:..::...|:..:.| .|..:.|.....|...:....:.:..:..||     ..|.|.:
Worm   289 TFSTEDSRTSMANLLF-LVDNMGMNNVVTPQYLNFSKNVIEMMKDEPF-----NCVEDCVGEEYS 347

  Fly   355 SVPIYGLHLYDSVMIYVRAITEVLRLG--GDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEG 417
            ||..|...|.|:...|..|:..:|...  .:|.:|.:::.:| ..::..:.|.|:.:|.:.....
Worm   348 SVAKYAGQLADAFYAYAVAVNRLLTANPQAEIRNGTMILRNI-GMTFEGVGGGDLTVDPDSARTS 411

  Fly   418 NYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRP-PLAEPL 481
            ...:|.|.:              |..|..:.....|:....|..:.:|..:...|||. |.|:|.
Worm   412 EIIMIGLNS--------------SRLPETYGKLIINNQSVHFEQLYSDEVMDVWNGRQRPKAKPT 462

  Fly   482 CGFHGELCPRKKLDW--RYLVSGPLCALVVVVAIALL-------------IKHYRYEQTLAGLLW 531
            |||.|..||.   |:  .|||      :|:::.:.|:             |:..|.|......||
Worm   463 CGFTGTQCPP---DFVRDYLV------IVIIIVMFLIFAVSAAVGAVFYAIRQKRKEIERQDELW 518

  Fly   532 KVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALF-----RGNIVAMKKIHK 591
            .|:...:..|:....:..:.::.......|..:..|  .|:.|...:|     |.|.|.....|.
Worm   519 HVEASHLKPISKKSKSEASQRSFASGPSTSTKLTVE--SRTETTRFIFYIYQVRNNEVVAANKHD 581

  Fly   592 KSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFI 656
            ....:|...|.||:.||.:.|:|:..|||...:...::....||:||||.||::...:.:|..|:
Worm   582 FRPQLTDVERSELRQMRSLDHDNLNKFIGLCLNSQQLLSIWRYCSRGSLADVISRSSMQMDSFFM 646

  Fly   657 SSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRA 721
            .||:.||..|:.::|.|.:..||.|.|.:||||.||..:||||||:|::      ...:|..:..
Worm   647 LSLIRDIANGLGFIHTSMLHFHGYLSSRSCLIDDRWQVKISDFGLNEVR------GMDKLSTENM 705

  Fly   722 LCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSK---EEIIQFVKCPEMLQH 783
            |..|||:||..   .:.|::.|:|||||:..|:|.|...: |....|   ||||.      .|:.
Worm   706 LWWAPEVLRGL---EQRSKEADIYSFGIICSEVITRSSAF-DLENRKEKPEEIIY------QLKK 760

  Fly   784 GVF---RPA-LTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSI 844
            |.|   ||: ||...|:|...:...:..||.|.|..||.|..||..|:.:..|.|.|:.|::.::
Worm   761 GGFNAIRPSLLTDEALEINPALVHLIRDCWTEKPSERPPIDQVRSLLRGMNDGKKGNLMDHVFNM 825

  Fly   845 MEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVG 909
            :|.||..||..|.|||..|.||:||:|:|||:|||:.|||.||.|..:|.|.|:.|||.|||:|.
Worm   826 LETYASTLEEEVNERTKELVEEQKKSDVLLYRMLPKTVAEKLKAGISIEPETFELVTIFFSDVVQ 890

  Fly   910 FTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLA 974
            ||.|.:..||.:||::|||.||..||||...||||||||||.|:.|||||.:||..|...||.::
Worm   891 FTTLASKCTPLQVVQLLNDLYTIFDSIIEQNDVYKVETIGDGYLCVSGLPHRNGHDHIKHIARMS 955

  Fly   975 LHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRI 1039
            |..|.::...::.|.|:|.:.||||::.|...|||||..|||||||||.|||||||||.|...||
Worm   956 LAFLSSLAEFRVAHMPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGRI 1020

  Fly  1040 HI-SEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL----------TKRQQPELTPDLISTV 1092
            |: |||.:.|..|:|.:...|||...|||||.|.||||          :..::.|.||.:..::
Worm  1021 HVSSEANHLLTHVVGGFRTEERGEVIIKGKGVMNTYWLLGENDSVPVKSNMRKRENTPSMARSI 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	82/453 (18%)
		ANF_receptor	59..427	CDD:279440	76/417 (18%)
		PHA02988	534..826	CDD:165291	96/303 (32%)
		PK_GC-A_B	550..832	CDD:270944	96/293 (33%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	107/192 (56%)
		Guanylate_cyc	892..1076	CDD:278633	101/184 (55%)
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141	81/434 (19%)
		ANF_receptor	47..398	CDD:279440	73/401 (18%)
		PKc_like	539..808	CDD:304357	95/286 (33%)
		Pkinase	567..803	CDD:278497	88/251 (35%)
		HNOBA	<824..867	CDD:285003	24/42 (57%)
		CYCc	846..1038	CDD:214485	107/191 (56%)
		Guanylate_cyc	873..1060	CDD:278633	103/186 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D229634at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870