Protein Alignment Gyc32E and gcy-15

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001364713.1
• Gene: gcy-15 / 191648
• WormBaseID: WBGene00001541
• Length: 1104
• Species: Caenorhabditis elegans
• Alignment Length: 1125
• Identity: 360/1125 - (32%)
• Similarity: 543/1125 - (48%)
• Gaps: 166/1125 - (14%)

  Fly    62 LPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESCTTEAL 126
            :.:||..:|.:.:|     ..|..:|:.:..::....|..|.|........|.:|....|..::.
 Worm     1 MEIAINRLNADKDL-----EVFHDLDVNYVDTSKTAGPRAARTAALNNATVAAMGLMRDCYIQST 60

  Fly   127 LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWG 191
            :.:......:|..|...:.|.|....|.....:..:.::|||:..|:.:.|.|.:: ||...:..
 Worm    61 ILNINLKIAVSDVCEMDLSSVKGFDQTSVLMNSQTNSLAKSVMYFLDKYQWKKVAL-VSPSAVLT 124

  Fly   192 SDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYV---------FIGE 247
            :..||...:|.:|  .|.:....:.|  .....:|.|.:.::|.....||::         .:..
 Worm   125 AFAARVRSDLLDA--LTANKIDILVD--SRLDPMSDITEKVKEDAEKARIFIICDWSSNANLLRN 185

  Fly   248 HIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSN----------RRVNIMERNYLDPYIRKEKS 302
            :|    |..|..|:  ::||:|.|:....  ||:|          :|:..:..:.::.|...|
 Worm   186 YI----FKLGEMNK--MQSGEYFVLGYIS--YDTNYQWLEASSGDQRLVHLGASDINDYNLTE-- 240

  Fly   303 KSLDKISFRSVIKISMTYP---QNPHIRDICSKI--KDYARKTPFLVPY-----HQRV---FDNI 354
            ..|.:: :::|:.:|...|   .|....||.:::  |..|:..|   ||     .:::   :|.|
 Worm   241 NDLHEV-YKNVVILSDGPPPAEPNSTWEDIKTQVLKKKPAKMCP---PYCNTTISEKITPRWDRI 301

  Fly   355 SVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNY 419
            .:      |:||:.....|..:.|.:|.:||..::...|:.:|...|:.|...|||
 Worm   302 KL------LFDSIQYLADATNDALNIGANIYQSDIFYEHLISRKVDSVTGVTEYID--------- 351

  Fly   420 TVITLQNDVGSGASIGSLAKMSMQPVGFF---AYDKNSVIPEFRYIKND--------------RP 467
                     |.||.:|     |||....|   :::..|:.|..|..::.              ..
 Worm   352 ---------GYGAIVG-----SMQIYYHFSSSSHNSYSLFPCARLAQSSLLNTVWSLTDYSEGLS 402

  Fly   468 IQWLNGRPPLAEPLCGFHGELC-PRKKLDWRYLVSGPLCALV-VVVAIALLIKHYRYEQTLAGLL 530
            |.::|...|...|:|||:||.| |.....:..::|..:..|: :.:|.|.|.|.||||:.|..|.
 Worm   403 IDFVNKSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAVLIGLAIAAAFLYKRYRYERRLHSLF 467

  Fly   531 WKVDMKDVTV---INL------------------------------GEYNNPTNKNIFQICRQSI 562
            :.:|...:.:   .||                              .:|||.::.|...|.....
 Worm   468 FMIDRNQIILKKHTNLMSQQSLRSMASIHGSVVAASQTLRDSHFFIEDYNNASSINASSIFNTGS 532

  Fly   563 L--------------VVGEPNKRSFTNI-----ALFRGNIVAMKKIHKKSVDITRSIRKELKLMR 608
            .              |.|......:..|     .|:.|..||:|:|::..|:.|||.|.|:..::
 Worm   533 TARAGPFGPIPGFGGVTGASEDEKWHQIPDFGVGLYEGRTVALKRIYRSDVEFTRSNRLEIAKLQ 597

  Fly   609 EVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDS 673
            |..:.|:|.|:|.......|.:......||||:|:|.|:|:.||.:|.|.:..||:.|:.|||.|
 Worm   598 ESVNSNVIEFVGMVVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSS 662

  Fly   674 EIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSEL-ELKRALCMAPELLRDAYRPGR 737
            .:..||.|:|:|||||:||:.::|.|||.||:..:....:.:: |.|..|..:|||||  :..|.
 Worm   663 PVGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLR--WSTGL 725

  Fly   738 GS------QKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLD 796
            ..      ||.||||..|:|||:.||.|||||......||:..||...:.....|||.:. ...:
 Worm   726 SQCGVLLVQKSDVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMA-VLKE 789

  Fly   797 IPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTN 861
            .|..:::.:...|.|||..||.:..::..||.|..|||..|.|||:|::|||...||..:.||..
 Worm   790 SPRIVQETVVAAWTEDPLNRPSLHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERNE 854

  Fly   862 LLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEML 926
            .|..||.|::.||..|||..||:.||.|..|.||.|:..|:.|||..||.|:..||.|.::|:.|
 Worm   855 ELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFL 919

  Fly   927 NDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPT 991
            ||.||..|.||..:||||||||.|||||.||||:.||:.||||||||.|.||:.|.:.||||.|.
 Worm   920 NDLYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFKIRHLPN 984

  Fly   992 ETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYV 1056
            |.|:||||::||||.|||||.||||||||||||||||||||.|..:||:.|....::|..:|.|.
 Worm   985 EKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYE 1049

  Fly  1057 CIERGLTSIKGKGDMRTYWL 1076
            ..|||:..:||||...||::
 Worm  1050 IEERGIVEMKGKGKQMTYFV 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	86/417 (21%)
		ANF_receptor	59..427	CDD:279440	79/396 (20%)
		PHA02988	534..826	CDD:165291	105/350 (30%)
		PK_GC-A_B	550..832	CDD:270944	102/307 (33%)
		HNOBA	<847..886	CDD:285003	17/38 (45%)
		CYCc	865..1057	CDD:214485	114/191 (60%)
		Guanylate_cyc	892..1076	CDD:278633	110/183 (60%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822	86/413 (21%)
		PK_GC	553..822	CDD:270894	97/271 (36%)
		HNOBA	<831..879	CDD:400168	22/47 (47%)
		Guanylate_cyc	885..1071	CDD:306677	110/185 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I1226
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880