DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and gcy-9

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	1121	Identity:	325/1121 - (28%)
Similarity:	528/1121 - (47%)	Gaps:	207/1121 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LPLAIEDVNKNPNLLP-GKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESCTTEA 125
            |.:..:|: |..|:|| ...|....::..:|.|.  |:....:..::.|.|  :.||  .|..|.
Worm    61 LKMCADDL-KMRNILPQNYTLTVFTMESCNKYSG--VEHAAFLHYLKNASV--YFGP--GCNNEM 118

  Fly   126 L----LASAWNTPMLSFKCSDPIVSNKSTFHTFAR-TLAPASKVSKSVISLLNAFHWNKFSIVVS 185
            |    ||..||.|:::....|..:|::..|.|... .|..||:::|:.::.||..:|::..||
Worm   119 LVIGRLAPRWNVPIIAHMSGDDALSDRVQFPTLGSVALTSASEMAKATVTYLNLNNWDQIGIV-- 181

  Fly   186 SKPIWGSD--VARAIQELAEARNFT------ISHFKYISDYIPTTK--TLSQIDKIIEETYATTR 240
             :|..|.:  ...::|...:.|:..      |..|....:.|.|.|  ||..:.:|
Worm   182 -RPSVGYERLSVYSLQHQIKKRDINLNVILDIEPFSSPEEIISTGKLTTLKSMARI--------- 236

  Fly   241 IYVFIGEHI-AMVDFVRGLQNRRLLESGDYIVV----SVDDEIYDSNRRVNIMERNYLDPYIRKE 300
            |.|.:|..| ::.:|:..: :|..:::.:::.|    :..::.|               |:....
Worm   237 IVVELGMDIHSVTNFMLAI-HRSEIKNEEFVFVIPWLAHQNDHY---------------PWEAAN 285

  Fly   301 KSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYG----- 360
            ..|...|::|.:.|.|:      .|                   .|.::.||:..:....
Worm   286 VDKQEVKLAFENTIIIT------AH-------------------GYDKKFFDDFQMKFSAVTGVL 325

  Fly   361 ---------LHLYDSVMIYVRAITEVLRLGGDI---YDGNLVMSHIFNRSYHSIQGFDVYIDSNG 413
                     :.|||::.:|..|:.:....||..   .:|:|:.|.:.||.         :|...|
Worm   326 ANHYATLSYMSLYDALFLYGLALRDAFEDGGGYNVHMNGSLIWSRMTNRQ---------FIGMTG 381

  Fly   414 DAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDR------------ 466
            ....|...|.:.:.....|..|:|                .::.|.....|||
Worm   382 QVLMNNKAIRVPSYATYHAINGTL----------------KIVVELEAKNNDRGQCEKNEEMCSE 430

  Fly   467 -----PIQWL----NGRPPLAEPLCGFHGELCPRKKLDWR-YLVSGPLCALVVVVA-IALLIKHY 520
                 .||:.    :|:.|.|.|.|||.|..|     |:| |.:...|.|.::.|. ::..|...
Worm   431 HVAHETIQYYWPSDSGKLPPAVPKCGFTGAEC-----DYRPYFIGASLLAFILTVGPLSYFIYLK 490

  Fly   521 RYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGNIVA 585
            :.|:.|..:.|::..:.:.::   |..:.:..::....:.|....|..|.:        :..::|
Worm   491 QKERLLYDMTWRIPRESIKML---EGKSKSEHSLASKSQSSGSFSGSMNSK--------QNGLIA 544

  Fly   586 MK-------KIHKKSVDITRSI---RKELKLMREVR---HENIINFIGAS-TDHGSVIIFTTYCA 636
            .|       |:..|.....|:|   :.||:|::|::   ::|:..|.|.| ......|:....|:
Worm   545 AKQAVSNGVKLAIKRYQQVRNITFPKSELRLLKELKICENDNLNKFYGISFNQQNEFIVMWVLCS 609

  Fly   637 RGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGL 701
            ||||||:|.|::|.|...|..|...|::||:.:||.|.::.||.|...|||:||.|..::::|..
Worm   610 RGSLEDILFNDELKLGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNFAT 674

  Fly   702 ----------HELKA----------GQEEPNKSELELKRALCMAPELLRDAYRP---GRGSQKGD 743
                      :||:.          ...:|.| :...|:.|..|||::|:....   ..|||..|
Worm   675 EAVIFEKLDHNELRPFINTDSESADDVSDPTK-DFARKKYLQQAPEIIREIVTTKTIPEGSQSAD 738

  Fly   744 VYSFGILLYEMIGRKGPWGDTAYSKEEIIQ---FVKCPEMLQHGVFRPALTHTHLDIPDYIRKCL 805
            :|:.|::||:::.|..|:.:...|..::::   .....:.|....|..:.|....::  .:..|:
Worm   739 IYALGMVLYQILFRVEPFHERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNL--QLLSCI 801

  Fly   806 CQCWDEDPEVRPDIRLVR-MHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKK 869
            ..||.|.||:||.|:.|| |....|::..|.::.|.|:.:||:|..|||.:|::||.||.|.:|:
Worm   802 EACWLEIPEMRPPIKKVRTMVNANLKSTGKGSLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQ 866

  Fly   870 TDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCD 934
            .|.||..|||:.:||.||.|.||..:.:.|.|:|||||.|||.:.:||||.:||..|||.::..|
Worm   867 ADRLLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDIRGFTRISSTSTPLQVVTFLNDMFSGFD 931

  Fly   935 SIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIG 999
            :||:.:|.|||||||||||:|||:|.:||:.||..||.:||.:...:.|.|:.|:|.|.:.:|||
Worm   932 AIIAKHDAYKVETIGDAYMIVSGVPTENGNSHAQNIADVALKMRAFICNFKLAHRPEELMMVRIG 996

  Fly  1000 VHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQ-VIGSYVCIERGLT 1063
            .||||.||||||...||||||||||||||||||||.:.:|.|||..|.||. ....:..:|||..
Worm   997 FHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVANKIQISEGAYNLLHCFFPQFQMVERGKI 1061

  Fly  1064 SIKGKGDMRTYWLTKR 1079
            .:||||:..||:|..|
Worm  1062 EVKGKGECLTYYLEGR 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	84/423 (20%)
		ANF_receptor	59..427	CDD:279440	81/402 (20%)
		PHA02988	534..826	CDD:165291	84/332 (25%)
		PK_GC-A_B	550..832	CDD:270944	84/322 (26%)
		HNOBA	<847..886	CDD:285003	19/38 (50%)
		CYCc	865..1057	CDD:214485	106/192 (55%)
		Guanylate_cyc	892..1076	CDD:278633	101/184 (55%)
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141	84/434 (19%)
		ANF_receptor	69..404	CDD:279440	80/402 (20%)
		PKc_like	550..820	CDD:304357	76/272 (28%)
		HNOBA	<837..883	CDD:285003	22/45 (49%)
		CYCc	862..1054	CDD:214485	106/191 (55%)
		Guanylate_cyc	889..1076	CDD:278633	102/186 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG29007
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930