Protein Alignment Gyc32E and gcy-9

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_509897.3
• Gene: gcy-9 / 191645
• WormBaseID: WBGene00001536
• Length: 1081
• Species: Caenorhabditis elegans
• Alignment Length: 1121
• Identity: 325/1121 - (28%)
• Similarity: 528/1121 - (47%)
• Gaps: 207/1121 - (18%)

  Fly    62 LPLAIEDVNKNPNLLP-GKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESCTTEA 125
            |.:..:|: |..|:|| ...|....::..:|.|.  |:....:..::.|.|  :.||  .|..|.
 Worm    61 LKMCADDL-KMRNILPQNYTLTVFTMESCNKYSG--VEHAAFLHYLKNASV--YFGP--GCNNEM 118

  Fly   126 L----LASAWNTPMLSFKCSDPIVSNKSTFHTFAR-TLAPASKVSKSVISLLNAFHWNKFSIVVS 185
            |    ||..||.|:::....|..:|::..|.|... .|..||:::|:.::.||..:|::..||
 Worm   119 LVIGRLAPRWNVPIIAHMSGDDALSDRVQFPTLGSVALTSASEMAKATVTYLNLNNWDQIGIV-- 181

  Fly   186 SKPIWGSD--VARAIQELAEARNFT------ISHFKYISDYIPTTK--TLSQIDKIIEETYATTR 240
             :|..|.:  ...::|...:.|:..      |..|....:.|.|.|  ||..:.:|
 Worm   182 -RPSVGYERLSVYSLQHQIKKRDINLNVILDIEPFSSPEEIISTGKLTTLKSMARI--------- 236

  Fly   241 IYVFIGEHI-AMVDFVRGLQNRRLLESGDYIVV----SVDDEIYDSNRRVNIMERNYLDPYIRKE 300
            |.|.:|..| ::.:|:..: :|..:::.:::.|    :..::.|               |:....
 Worm   237 IVVELGMDIHSVTNFMLAI-HRSEIKNEEFVFVIPWLAHQNDHY---------------PWEAAN 285

  Fly   301 KSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYG----- 360
            ..|...|::|.:.|.|:      .|                   .|.::.||:..:....
 Worm   286 VDKQEVKLAFENTIIIT------AH-------------------GYDKKFFDDFQMKFSAVTGVL 325

  Fly   361 ---------LHLYDSVMIYVRAITEVLRLGGDI---YDGNLVMSHIFNRSYHSIQGFDVYIDSNG 413
                     :.|||::.:|..|:.:....||..   .:|:|:.|.:.||.         :|...|
 Worm   326 ANHYATLSYMSLYDALFLYGLALRDAFEDGGGYNVHMNGSLIWSRMTNRQ---------FIGMTG 381

  Fly   414 DAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDR------------ 466
            ....|...|.:.:.....|..|:|                .::.|.....|||
 Worm   382 QVLMNNKAIRVPSYATYHAINGTL----------------KIVVELEAKNNDRGQCEKNEEMCSE 430

  Fly   467 -----PIQWL----NGRPPLAEPLCGFHGELCPRKKLDWR-YLVSGPLCALVVVVA-IALLIKHY 520
                 .||:.    :|:.|.|.|.|||.|..|     |:| |.:...|.|.::.|. ::..|...
 Worm   431 HVAHETIQYYWPSDSGKLPPAVPKCGFTGAEC-----DYRPYFIGASLLAFILTVGPLSYFIYLK 490

  Fly   521 RYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGNIVA 585
            :.|:.|..:.|::..:.:.::   |..:.:..::....:.|....|..|.:        :..::|
 Worm   491 QKERLLYDMTWRIPRESIKML---EGKSKSEHSLASKSQSSGSFSGSMNSK--------QNGLIA 544

  Fly   586 MK-------KIHKKSVDITRSI---RKELKLMREVR---HENIINFIGAS-TDHGSVIIFTTYCA 636
            .|       |:..|.....|:|   :.||:|::|::   ::|:..|.|.| ......|:....|:
 Worm   545 AKQAVSNGVKLAIKRYQQVRNITFPKSELRLLKELKICENDNLNKFYGISFNQQNEFIVMWVLCS 609

  Fly   637 RGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGL 701
            ||||||:|.|::|.|...|..|...|::||:.:||.|.::.||.|...|||:||.|..::::|..
 Worm   610 RGSLEDILFNDELKLGRNFQVSFAKDVVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNFAT 674

  Fly   702 ----------HELKA----------GQEEPNKSELELKRALCMAPELLRDAYRP---GRGSQKGD 743
                      :||:.          ...:|.| :...|:.|..|||::|:....   ..|||..|
 Worm   675 EAVIFEKLDHNELRPFINTDSESADDVSDPTK-DFARKKYLQQAPEIIREIVTTKTIPEGSQSAD 738

  Fly   744 VYSFGILLYEMIGRKGPWGDTAYSKEEIIQ---FVKCPEMLQHGVFRPALTHTHLDIPDYIRKCL 805
            :|:.|::||:::.|..|:.:...|..::::   .....:.|....|..:.|....::  .:..|:
 Worm   739 IYALGMVLYQILFRVEPFHERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNL--QLLSCI 801

  Fly   806 CQCWDEDPEVRPDIRLVR-MHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKK 869
            ..||.|.||:||.|:.|| |....|::..|.::.|.|:.:||:|..|||.:|::||.||.|.:|:
 Worm   802 EACWLEIPEMRPPIKKVRTMVNANLKSTGKGSLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQ 866

  Fly   870 TDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCD 934
            .|.||..|||:.:||.||.|.||..:.:.|.|:|||||.|||.:.:||||.:||..|||.::..|
 Worm   867 ADRLLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDIRGFTRISSTSTPLQVVTFLNDMFSGFD 931

  Fly   935 SIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIG 999
            :||:.:|.|||||||||||:|||:|.:||:.||..||.:||.:...:.|.|:.|:|.|.:.:|||
 Worm   932 AIIAKHDAYKVETIGDAYMIVSGVPTENGNSHAQNIADVALKMRAFICNFKLAHRPEELMMVRIG 996

  Fly  1000 VHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQ-VIGSYVCIERGLT 1063
            .||||.||||||...||||||||||||||||||||.:.:|.|||..|.||. ....:..:|||..
 Worm   997 FHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVANKIQISEGAYNLLHCFFPQFQMVERGKI 1061

  Fly  1064 SIKGKGDMRTYWLTKR 1079
            .:||||:..||:|..|
 Worm  1062 EVKGKGECLTYYLEGR 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	84/423 (20%)
		PK_GC-A_B	550..832	CDD:270944	84/322 (26%)
		CYCc	865..1057	CDD:214485	106/192 (55%)
gcy-9	NP_509897.3	PBP1_NPR_GC-like	66..416	CDD:380575	84/434 (19%)
		Protein Kinases, catalytic domain	550..820	CDD:473864	76/272 (28%)
		HNOBA	<835..883	CDD:462234	23/47 (49%)
		CYCc	862..1054	CDD:214485	106/191 (55%)