Protein Alignment Gyc32E and gcy-6

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001294696.1
• Gene: gcy-6 / 191644
• WormBaseID: WBGene00001533
• Length: 1086
• Species: Caenorhabditis elegans
• Alignment Length: 1131
• Identity: 336/1131 - (29%)
• Similarity: 523/1131 - (46%)
• Gaps: 173/1131 - (15%)

  Fly    42 DTINIGFL------------AEYSQMRVTLGGLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSA 94
            :..::|||            ..|...|.:.....:||:.: |...||.|....|   .|.:....
 Worm    26 NVFHLGFLHCDVLENNVEGSTTYINYRTSASAASIAIDKI-KREGLLLGYDFKF---TILYDQCD 86

  Fly    95 YRVKPLRAMTQMREAGVTAFIGP--DESCTTEALLASAWNTPMLSFK-CSDPIVSNKSTFHTFAR 156
            ..:....|:....|..|....||  :.:.....:||:.:|.|::::. .|...:.::|.|.|...
 Worm    87 ENIAAGNAIKLFAEHNVDVLFGPTTNNAAMPVFILATYYNIPLITWGITSSATLDDESRFPTAGM 151

  Fly   157 TLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDVARAIQE-----LAEARNFTISHFKYIS 216
            ....:..::.:...::..:.|::|....|.:  ...:....:::     :|...:..:|:...|.
 Worm   152 LSIGSRSLAVTFREVMKEYGWDQFVFAYSLE--MNDEKCETLRDDFQNMVAYYGDIVLSYAVQIM 214

  Fly   217 DY-----IPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLL---ESGDYIVVS 273
            |:     :...|.:|...:||...:....              .|||..|.:|   .:|     .
 Worm   215 DHSEEGLLAILKDVSTRGRIIVPCFHEGN--------------SRGLHRRWMLVAARNG-----F 260

  Fly   274 VDDE---IYDSNRRVNIMERNYLDP-------YIRKEKS--------------KSLDKISFRSVI 314
            |:||   |:.|.|     .|.|..|       |...|.:              ||:..:..:...
 Worm   261 VNDEYVYIFPSLR-----SRGYAVPQADGTFRYPWTEATGPQPGDQEALLGFQKSIFIVDMQGQG 320

  Fly   315 KISMTYPQNPHIRDICSKIKD--YARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEV 377
            .:...|.|..|  :|..::|:  |........|.:|      :...|...|:|||.||...:.::
 Worm   321 NVGSNYTQFEH--EIIQRMKEPPYNCTDACASPEYQ------TAATYAGQLHDSVYIYGVVMDQI 377

  Fly   378 LRLGGDIYDGNLV----MSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLA 438
            ::...:.|.....    |:.:||.     .|..|.||..|..:....|:||  |..:.:|:....
 Worm   378 MKTVPNQYKNGTAFPRKMAGVFNG-----VGGTVAIDEGGGLQPTLFVLTL--DSNNNSSLIMTV 435

  Fly   439 KMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNG---RPPLAEPLCGFHGELCPRKKLDWRYLV 500
            .:..|         .:|:.  ::..|:....|.:.   ||| .:|:||:.|.||| ..:.::|:
 Worm   436 DVDQQ---------EAVVT--KHYTNEATALWSHRKGIRPP-DQPICGYTGSLCP-ANVFFQYI- 486

  Fly   501 SGPLCALVVVVAIALL--------IKHYRYEQT-LAGLLWKVDMKD---VTVINLGEYNNPTNKN 553
             |...|.::::...::        :.|.:.::. ....||::..|.   ||....||::..:..:
 Worm   487 -GWFIAAIIIIFFTIMGAILAFIYLCHAKQQEVERQNALWQIPFKSMMTVTKKGKGEHSMRSISS 550

  Fly   554 I---FQICRQSIL-VVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIR-----KELKLMRE 609
            :   ....|.|.| .|||.....|..|.    |.|.|:::..|.    .|||     |....||:
 Worm   551 VPSTISSTRSSTLSEVGETRNYLFFQIQ----NDVEMERVAAKK----HSIRMVFDNKTCATMRQ 607

  Fly   610 VR---HENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLH 671
            :|   |.|:..|||.|.|...:.....:|:||||.||:....:.:|..||.||:.||:.|:.::|
 Worm   608 MRLIDHANLNKFIGMSLDAPQLYSVWRFCSRGSLADVIRKASMQMDGFFIYSLMKDIINGLTWIH 672

  Fly   672 DSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLR--DAYR 734
            :|....||.|.|.|||::.||..:|:||||...:. .::.|||:     .|..:|||||  |..
 Worm   673 ESSHEFHGMLTSKNCLLNDRWQLKITDFGLRIFRT-HDQYNKSD-----RLWTSPELLRTDDIL- 730

  Fly   735 PGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVF---RPALTHTH-L 795
               ||::||:|||||:..|:|.|...: |....||:..:.:   .||:.|..   ||:|.|.. :
 Worm   731 ---GSREGDIYSFGIISAELITRSSVF-DLENRKEDAEEII---YMLKKGGLQSPRPSLEHDESI 788

  Fly   796 DIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERT 860
            :|...:...:..||.|.|..||||:.|...|:.:......|:.|::.:::|.||..||..|.||.
 Worm   789 EINPALLHLVRDCWTERPSERPDIKQVASQLRSMNTNRNDNLMDHVFNVLESYASTLEDEVAERM 853

  Fly   861 NLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEM 925
            ..|.|||||:|:|||:||||.||:.||.|..||.|.||.||:.|||:|.||.|....||.:||.:
 Worm   854 KELVEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLFFSDVVSFTTLAGKCTPLQVVNL 918

  Fly   926 LNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKP 990
            ||..||..|.||..:||||||||||.|.|.||:|.:||:.|...|||::::.::::.:..|.|.|
 Worm   919 LNGLYTIFDGIIEQHDVYKVETIGDGYFVASGVPRRNGNEHTRNIASMSINFVKSLADFSIPHLP 983

  Fly   991 TETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSY 1055
            .|.:::|:|.|.|...|||||..|||||||||.|||||||||.....:||:||...|:|..:|.:
 Worm   984 GEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNSKPGQIHLSEEANQMLMRLGGF 1048

  Fly  1056 VCIERGLTSIKGKGDMRTYWLTKRQQ 1081
            ....||...|||||.|.||||.|..:
 Worm  1049 TTEPRGEVIIKGKGVMATYWLLKMDE 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	86/461 (19%)
		PK_GC-A_B	550..832	CDD:270944	100/299 (33%)
		CYCc	865..1057	CDD:214485	102/191 (53%)
gcy-6	NP_001294696.1	PBP1_NPR_GC-like	44..445	CDD:380575	84/454 (19%)
		Protein Kinases, catalytic domain	585..822	CDD:473864	89/254 (35%)
		CYCc	858..1048	CDD:214485	102/189 (54%)