DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and gcy-6

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001294696.1	Gene:	gcy-6 / 191644	WormBaseID:	WBGene00001533	Length:	1086	Species:	Caenorhabditis elegans

Alignment Length:	1131	Identity:	336/1131 - (29%)
Similarity:	523/1131 - (46%)	Gaps:	173/1131 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DTINIGFL------------AEYSQMRVTLGGLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSA 94
            :..::|||            ..|...|.:.....:||:.: |...||.|....|   .|.:....
Worm    26 NVFHLGFLHCDVLENNVEGSTTYINYRTSASAASIAIDKI-KREGLLLGYDFKF---TILYDQCD 86

  Fly    95 YRVKPLRAMTQMREAGVTAFIGP--DESCTTEALLASAWNTPMLSFK-CSDPIVSNKSTFHTFAR 156
            ..:....|:....|..|....||  :.:.....:||:.:|.|::::. .|...:.::|.|.|...
Worm    87 ENIAAGNAIKLFAEHNVDVLFGPTTNNAAMPVFILATYYNIPLITWGITSSATLDDESRFPTAGM 151

  Fly   157 TLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDVARAIQE-----LAEARNFTISHFKYIS 216
            ....:..::.:...::..:.|::|....|.:  ...:....:::     :|...:..:|:...|.
Worm   152 LSIGSRSLAVTFREVMKEYGWDQFVFAYSLE--MNDEKCETLRDDFQNMVAYYGDIVLSYAVQIM 214

  Fly   217 DY-----IPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLL---ESGDYIVVS 273
            |:     :...|.:|...:||...:....              .|||..|.:|   .:|     .
Worm   215 DHSEEGLLAILKDVSTRGRIIVPCFHEGN--------------SRGLHRRWMLVAARNG-----F 260

  Fly   274 VDDE---IYDSNRRVNIMERNYLDP-------YIRKEKS--------------KSLDKISFRSVI 314
            |:||   |:.|.|     .|.|..|       |...|.:              ||:..:..:...
Worm   261 VNDEYVYIFPSLR-----SRGYAVPQADGTFRYPWTEATGPQPGDQEALLGFQKSIFIVDMQGQG 320

  Fly   315 KISMTYPQNPHIRDICSKIKD--YARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEV 377
            .:...|.|..|  :|..::|:  |........|.:|      :...|...|:|||.||...:.::
Worm   321 NVGSNYTQFEH--EIIQRMKEPPYNCTDACASPEYQ------TAATYAGQLHDSVYIYGVVMDQI 377

  Fly   378 LRLGGDIYDGNLV----MSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLA 438
            ::...:.|.....    |:.:||.     .|..|.||..|..:....|:||  |..:.:|:....
Worm   378 MKTVPNQYKNGTAFPRKMAGVFNG-----VGGTVAIDEGGGLQPTLFVLTL--DSNNNSSLIMTV 435

  Fly   439 KMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNG---RPPLAEPLCGFHGELCPRKKLDWRYLV 500
            .:..|         .:|:.  ::..|:....|.:.   ||| .:|:||:.|.||| ..:.::|:
Worm   436 DVDQQ---------EAVVT--KHYTNEATALWSHRKGIRPP-DQPICGYTGSLCP-ANVFFQYI- 486

  Fly   501 SGPLCALVVVVAIALL--------IKHYRYEQT-LAGLLWKVDMKD---VTVINLGEYNNPTNKN 553
             |...|.::::...::        :.|.:.::. ....||::..|.   ||....||::..:..:
Worm   487 -GWFIAAIIIIFFTIMGAILAFIYLCHAKQQEVERQNALWQIPFKSMMTVTKKGKGEHSMRSISS 550

  Fly   554 I---FQICRQSIL-VVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIR-----KELKLMRE 609
            :   ....|.|.| .|||.....|..|.    |.|.|:::..|.    .|||     |....||:
Worm   551 VPSTISSTRSSTLSEVGETRNYLFFQIQ----NDVEMERVAAKK----HSIRMVFDNKTCATMRQ 607

  Fly   610 VR---HENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLH 671
            :|   |.|:..|||.|.|...:.....:|:||||.||:....:.:|..||.||:.||:.|:.::|
Worm   608 MRLIDHANLNKFIGMSLDAPQLYSVWRFCSRGSLADVIRKASMQMDGFFIYSLMKDIINGLTWIH 672

  Fly   672 DSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLR--DAYR 734
            :|....||.|.|.|||::.||..:|:||||...:. .::.|||:     .|..:|||||  |..
Worm   673 ESSHEFHGMLTSKNCLLNDRWQLKITDFGLRIFRT-HDQYNKSD-----RLWTSPELLRTDDIL- 730

  Fly   735 PGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVF---RPALTHTH-L 795
               ||::||:|||||:..|:|.|...: |....||:..:.:   .||:.|..   ||:|.|.. :
Worm   731 ---GSREGDIYSFGIISAELITRSSVF-DLENRKEDAEEII---YMLKKGGLQSPRPSLEHDESI 788

  Fly   796 DIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERT 860
            :|...:...:..||.|.|..||||:.|...|:.:......|:.|::.:::|.||..||..|.||.
Worm   789 EINPALLHLVRDCWTERPSERPDIKQVASQLRSMNTNRNDNLMDHVFNVLESYASTLEDEVAERM 853

  Fly   861 NLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEM 925
            ..|.|||||:|:|||:||||.||:.||.|..||.|.||.||:.|||:|.||.|....||.:||.:
Worm   854 KELVEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLFFSDVVSFTTLAGKCTPLQVVNL 918

  Fly   926 LNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKP 990
            ||..||..|.||..:||||||||||.|.|.||:|.:||:.|...|||::::.::::.:..|.|.|
Worm   919 LNGLYTIFDGIIEQHDVYKVETIGDGYFVASGVPRRNGNEHTRNIASMSINFVKSLADFSIPHLP 983

  Fly   991 TETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSY 1055
            .|.:::|:|.|.|...|||||..|||||||||.|||||||||.....:||:||...|:|..:|.:
Worm   984 GEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNSKPGQIHLSEEANQMLMRLGGF 1048

  Fly  1056 VCIERGLTSIKGKGDMRTYWLTKRQQ 1081
            ....||...|||||.|.||||.|..:
Worm  1049 TTEPRGEVIIKGKGVMATYWLLKMDE 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	86/461 (19%)
		ANF_receptor	59..427	CDD:279440	78/413 (19%)
		PHA02988	534..826	CDD:165291	104/312 (33%)
		PK_GC-A_B	550..832	CDD:270944	100/299 (33%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	102/191 (53%)
		Guanylate_cyc	892..1076	CDD:278633	94/183 (51%)
gcy-6	NP_001294696.1	PBP1_NPR_GC_like	29..445	CDD:107347	87/469 (19%)
		ANF_receptor	57..424	CDD:279440	78/411 (19%)
		PKc_like	585..822	CDD:304357	89/254 (35%)
		HNOBA	<847..879	CDD:285003	19/31 (61%)
		CYCc	858..1048	CDD:214485	102/189 (54%)
		Guanylate_cyc	885..1070	CDD:278633	95/184 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020