Protein Alignment Gyc32E and gcy-4

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_496218.2
• Gene: gcy-4 / 191642
• WormBaseID: WBGene00001531
• Length: 1136
• Species: Caenorhabditis elegans
• Alignment Length: 1069
• Identity: 311/1069 - (29%)
• Similarity: 501/1069 - (46%)
• Gaps: 213/1069 - (19%)

  Fly   164 VSKSVISLLNAFHWNKFSIVVS-----------------SKPI--WGSDVARAIQELAEARNFTI 209
            ::.:|.:.||....|.:.:::.                 .||:  ||.        ::|:....:
 Worm    81 LANTVRAGLNFMKTNNYDVIIGPPCAPALKMMGTLSTIYKKPVLGWGF--------VSESEISDM 137

  Fly   210 SHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDY---IV 271
            :.|.:::..:|:||||..:...:.|.|...|        :|::.|...|         ||   :|
 Worm   138 NRFPFVASVLPSTKTLGVVTSKLLEIYGWDR--------VALLYFKNEL---------DYCSSVV 185

  Fly   272 VSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLD------------------------------ 306
            ..|:..:|:.::.|.|:.:..:|....:..|.:|.
 Worm   186 NDVEKSLYNESKSVQIVMKAEIDGSNSESTSATLQVVKTRARVILFCAHAGGEKRFYLIQAGLLG 250

  Fly   307 ---------KISFRSV---IKISM---------------TYPQNPH--------------IRDIC 330
                     .:|.|||   ::.|:               ::..||.              :.|..
 Worm   251 MNSSEYVHVMLSMRSVGFGVQTSVGKKPLTLSGLPPIWESFTVNPDGMEDLAKSVAAKMIVIDTS 315

  Fly   331 SKIKD------------YA-RKTPFLVPYHQRVFDNIS-VPIYGLHLYDSVMIYVRAITEVLRLG 381
            |:::|            || |:.|......:.:..|.: :..|..||:|...:|..|::.:....
 Worm   316 SEVRDKTFLQYMTKNIVYAIREPPLSCKVPECLITNATGMGAYARHLFDVFYMYGMAVSSLNSTD 380

  Fly   382 GDIYDGNL-VMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIG-SLAKMSMQP 444
            .::| ||| ::...|..::..:.| :|.::.:...:..|.|..|.::....:.|. ||...::..
 Worm   381 PNVY-GNLSLLIPKFTTAFEGMTG-EVKLNEDLARKPLYQVYGLNSEYDQISLIDISLINDTVNV 443

  Fly   445 VGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLD-WRYLVSGP----- 503
            |..:| |.|:.:..|          |...||| ..|:|||.|:.||....: :|.||...
 Worm   444 VFNYA-DGNTEVWHF----------WGGTRPP-DTPVCGFLGKSCPLPIFEQYRALVIVAIAVTI 496

  Fly   504 LCALVVVVAIALLIKHYRYEQTLAGLLWKV---------------DMKDVTVINLGEYNNPTNKN 553
            |..|.:::.::..|::.|.||:.....|::               ..::....:..|..|.|:|:
 Worm   497 LILLAIIICMSSKIRNRRVEQSRLHSEWQIHAIKLRLPMHRRASKSSQESETESASETENFTSKS 561

  Fly   554 IFQICRQSILVVGEPNKRSF--TNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENII 616
                        |:.....|  |....:..|.:.:...|:........:.|.:|| |::.|||:.
 Worm   562 ------------GDTMTSEFKETYTIQYLENDLVLTTAHQVQELSQAEMMKFVKL-RKLDHENLN 613

  Fly   617 NFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNL 681
            .|||.|.|....:.....|:||||:|:::.....:|:.|:..::.||.:|:.|:|.|.:..||||
 Worm   614 KFIGLSIDGSRFVSVWKMCSRGSLQDIISKGSFSMDYFFMFCMIRDIAEGLHYIHKSFLRHHGNL 678

  Fly   682 RSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYS 746
            ||:.||::..|..:::||||..|:..:|:|.|     |..|..|||::|.:....:.....|:||
 Worm   679 RSATCLVNDSWQVKLADFGLQFLQDEEEKPFK-----KNMLWAAPEVIRGSLSIEQMDSSADIYS 738

  Fly   747 FGILLYEMIGRKGPWGDTAYSK---EEIIQFVKCPEMLQHG--VFRPALTHTHLDIPDYIRKCLC 806
            |.|:..|::.::..| |.:..|   |||...||     :.|  |.||.| |..:::...:...:.
 Worm   739 FAIVASEILTKREAW-DLSRRKEGYEEIKYAVK-----KGGQFVLRPDL-HIDIEVNQTLLALVK 796

  Fly   807 QCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTD 871
            .||.|:||.||....|...|.::....:.|:.|::.|::|:|..:||..|.|||..|..||||:|
 Worm   797 DCWCENPEERPSAENVCKVLFDMTPNTEDNLMDHVFSMLEEYTSSLEVEVGERTKELTLEKKKSD 861

  Fly   872 MLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSI 936
            :||.:|||:.|||.||.|..||.|.||.||:.|||:|.||:|.:..:||:||.:|||.::..|||
 Worm   862 ILLGRMLPKQVAERLKAGQAVEPESFDLVTVFFSDLVKFTDLASKCSPFQVVNLLNDVFSNFDSI 926

  Fly   937 ISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVH 1001
            |..:||||||:|||.::.|||||.:||..|..:|..::|..:|...|.:|.|.|.|.|:||:|::
 Worm   927 IEKHDVYKVESIGDGFLCVSGLPNRNGMEHIRQIVGMSLCFMEFCRNFRIPHLPRERVELRVGIN 991

  Fly  1002 SGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSY----VCIERGL 1062
            ||||.|||||..|||||||||||||||||||.|....||:|||.:.||  :.:|    ....||.
 Worm   992 SGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLL--VNNYPYQFETNSRGE 1054

  Fly  1063 TSIKGKGDMRTYW------LTKRQQPELT 1085
            ..|||||.|.|||      |:.:..|.:|
 Worm  1055 VIIKGKGVMETYWLLGKMSLSNQSTPPIT 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	66/392 (17%)
		ANF_receptor	59..427	CDD:279440	62/370 (17%)
		PHA02988	534..826	CDD:165291	86/298 (29%)
		PK_GC-A_B	550..832	CDD:270944	85/288 (30%)
		HNOBA	<847..886	CDD:285003	21/38 (55%)
		CYCc	865..1057	CDD:214485	107/195 (55%)
		Guanylate_cyc	892..1076	CDD:278633	102/193 (53%)
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347	69/403 (17%)
		ANF_receptor	49..423	CDD:279440	61/368 (17%)
		PKc_like	558..819	CDD:304357	85/285 (30%)
		HNOBA	<834..876	CDD:285003	22/41 (54%)
		CYCc	855..1047	CDD:214485	107/193 (55%)
		Guanylate_cyc	882..1070	CDD:278633	102/189 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920