Protein Alignment Gyc32E and gcy-3

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_496037.1
• Gene: gcy-3 / 191641
• WormBaseID: WBGene00001530
• Length: 1140
• Species: Caenorhabditis elegans
• Alignment Length: 1233
• Identity: 358/1233 - (29%)
• Similarity: 548/1233 - (44%)
• Gaps: 236/1233 - (19%)

  Fly    27 PLAAGATVSSMR------RLTDTINIGFLAEYSQMRVTLGGLPLAIEDVNKN---PNLLPGKKLA 82
            |::.|.|...::      :.|.:.:||:       .|..|.:|||||.:.:.   .|......:.
 Worm    25 PVSTGTTRPKLKVGIAAAQKTQSASIGW-------NVCGGAVPLAIERLKQAGYVTNFDFEYYVE 82

  Fly    83 FKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGP--DESCTTEALLASAWNTPMLSFK-CSDPI 144
            :...|:.   |..|.    .:..::...|...|||  .|:..|.|.||:.:..|:|.:. .|...
 Worm    83 YTECDLA---STVRT----GINFLKNLEVDVIIGPPCSEAIRTMATLATLYKKPVLGWGFVSQAD 140

  Fly   145 VSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPI-------------WGSDVAR 196
            :|:.:.|......|..:..:..:...||..:.|:|.:::.....:             :......
 Worm   141 LSDMTRFPYLITVLPTSQTLGYAASKLLELYKWDKVALLYYKSEVNHCGGVMNDVETTFNDPSTY 205

  Fly   197 AIQELAEAR---------NFTISHFKYIS--------------DYIPTTKTLS-QIDKIIEETYA 237
            :||.:.:|.         |..||..|..:              ||:.....|. ..|:.:....:
 Worm   206 SIQIVLKAEIDASDNVTTNAVISSVKTRARIILWCAQLGSEKRDYMIKISQLGLDTDEYVHVLIS 270

  Fly   238 TTRI----YVFIGEHI-----------AMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNI 287
            ...|    ..|:|:..           :..:...||:|.....:.:.:|:.::.|:.|
 Worm   271 MRSIGFGVQTFVGKTTFKLSGLTPVWESFSNVTDGLENVAKRGATNVLVIDLNSEVSD------- 328

  Fly   288 MERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFD 352
              :.||| |::            |:::.:....|.|      ||.: |....|.
 Worm   329 --KAYLD-YMQ------------RNILNVVKLPPLN------CSTV-DCVSSTA----------- 360

  Fly   353 NISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSN----- 412
             ..:..|..||:|.|.:|..|:|.|......:||....:...|..|::.:.|. |.|:.|
 Worm   361 -TGMGAYARHLFDVVYLYGIALTRVNSTDSAVYDDMSKLIPQFVTSFNGMTGL-VAINQNLSRMP 423

  Fly   413 ----GDAEGNYTVITLQN-DVGSGASIGSLAKMSMQPVGFFAY-DKNSVIPEFRYIKNDRPIQWL 471
                ...:..|...:|.| ....|.::.:::         .|| :::|.:..|          |
 Worm   424 LYQLYGLDEQYEQTSLMNLSFADGTTVATIS---------LAYSNESSAVWHF----------W- 468

  Fly   472 NGRPPLAEPLCGFHGELCPRKKLDWR------YLVSGPLCALVV--VVAIALLIKHYRYEQTLAG 528
            .|..|||.|:|||.|..||..  .|.      ::.:|....::.  ::....:||:.|.||....
 Worm   469 GGIRPLATPICGFLGNSCPLP--FWEQYGILIFVGAGVFLIMITTNLICFLFMIKNRREEQARIN 531

  Fly   529 LLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFT------NIALFRGNIVAMK 587
            ..|::..  |.:..|...:..|:|...|....:|  .||....:.:      .:.:|..::|...
 Worm   532 SEWQIPF--VKLRELERKSKGTSKRSLQSAPSTI--TGESKVSTGSEFCENYEVKMFEKDMVLTM 592

  Fly   588 K-----IHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANE 647
            |     ::|..:|      |.:|| |::.|||:..|||.|.|....|..|..|:||||.|:|...
 Worm   593 KFQYMNLNKADMD------KFVKL-RKLDHENLNKFIGLSIDSSQFISVTKLCSRGSLLDILYKG 650

  Fly   648 DLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEE-- 710
            :..:|..|:..::.|:.:||.|||.|.:..||||||:.||::..|..::::||..:|   .||
 Worm   651 NFSMDFFFMYCIIKDVAEGMSYLHKSFLRLHGNLRSATCLVNDSWQVKLAEFGFDQL---LEEIT 712

  Fly   711 PNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKE---EII 772
            |.|     :|.|..|||:||.:....:.....||:||.|:..|::.||..| |....||   |||
 Worm   713 PTK-----RRLLWAAPEVLRGSLTVSQMDPSADVFSFAIIASEILTRKEAW-DLKERKEGYDEII 771

  Fly   773 QFVKCPEMLQHGVF--RPALTHTHLDIPDY---IRKCLCQCWDEDPEVRPDIRLVRMHLKELQAG 832
            ..||     :.|.|  ||.:.   .|:||.   :...:..||.|.||.||....:...|::|...
 Worm   772 YRVK-----KGGSFPIRPDII---TDVPDVNPTLIALVKDCWAEAPEDRPTAENICEQLRDLMPK 828

  Fly   833 LKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECF 897
            .|.|:.|::.:::|:|...||..|:|||..|..||||.|:||.:|||:.|||.||.|..||.|.|
 Worm   829 TKSNLMDHVFNMLEEYTSTLEVEVEERTKELTLEKKKADLLLSRMLPKQVAERLKAGQTVEPEGF 893

  Fly   898 DCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQN 962
            |.||:.|||:|.||.|.:..|||:||.:|||.|:..|:||..:.|||||:|||.|:.|||||.:|
 Worm   894 DSVTVFFSDVVKFTILASKCTPFQVVNLLNDLYSNFDTIIEEHGVYKVESIGDGYLCVSGLPTRN 958

  Fly   963 GSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTA 1027
            |..|..:|..::|..::...|.||.|.|.|.|:|||||:||||.|||||..||||||||||||||
 Worm   959 GFNHIKQIVDMSLKFMDYCKNFKIPHLPRERVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTA 1023

  Fly  1028 SRMESTGDSMRIHISEATYQLL--QVIGSYVCIERGLTSIKGKGDMRTYW-----------LTKR 1079
            |||||.|....||::...:.||  .....|....||...|||||.|.|:|           ::.|
 Worm  1024 SRMESNGKPSLIHLTSDAHLLLMKHFPHQYETNSRGEVIIKGKGVMETFWVLGRSGDIEPSISNR 1088

  Fly  1080 QQPELTPDLISTVDTLDTYCSGPRESMEVSVHQYCSPASNNYRLGSCNCDTKCLYSRRSDDNV 1142
            ..|.:|.:.. ||...||     .|:..||.|. ..|:||:      |.:...||.:...|.:
 Worm  1089 STPPVTQERF-TVRAPDT-----PEARSVSSHG-SRPSSNH------NNNNDPLYRQYKMDTL 1138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	84/471 (18%)
		PK_GC-A_B	550..832	CDD:270944	97/302 (32%)
		CYCc	865..1057	CDD:214485	107/193 (55%)
gcy-3	NP_496037.1	PBP1_NPR_GC-like	36..452	CDD:380575	85/471 (18%)
		Protein Kinases, catalytic domain	554..823	CDD:473864	93/294 (32%)
		HNOBA	<838..882	CDD:462234	22/43 (51%)
		CYCc	861..1051	CDD:214485	106/189 (56%)