DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and acy-2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_504553.1	Gene:	acy-2 / 191607	WormBaseID:	WBGene00000069	Length:	1080	Species:	Caenorhabditis elegans

Alignment Length:	1015	Identity:	195/1015 - (19%)
Similarity:	334/1015 - (32%)	Gaps:	390/1015 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 VVSVDDEIYDSNRRVNIME--RNYLDPYIRKEKSKSL-----------------DKISFRSVIKI 316
            |:::...:.|||...|..|  |...:...|:.:.::|                 |::| :|:|:.
Worm   216 VIALVGVVADSNEAGNRAEIARKLTEAVYRRTELETLKDRQEQLLLSVIPAYLADQVS-KSIIQS 279

  Fly   317 SMT-----YPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITE 376
            |.|     .|:..         |:..:........|.:|.||:|:
Worm   280 SSTGSTVEVPRTG---------KNNTKNHKLFHDLHVQVHDNVSI-------------------- 315

  Fly   377 VLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMS 441
               |..||.                                |:||:..|
Worm   316 ---LFADIV--------------------------------NFTVLAAQ---------------- 329

  Fly   442 MQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKL--DWRYLVSG-P 503
                 ..|.|....:.|. |.|.||..|.|.                |.|.|.  |..|.||| |
Worm   330 -----LTAKDLVRTLNEL-YSKFDRDAQRLQ----------------CMRIKFLGDCYYCVSGMP 372

  Fly   504 L-----CALVVVVAIALL--IKHYRYE--------------QTLAGLL----WKVDM--KDVTVI 541
            :     ..:.||:.:.::  ||..|..              ..|.|::    |:.|:  .|||:.
Worm   373 VNRPNHADMCVVMGLEMINTIKQVRIATGVDVNMRIGVHTGSVLCGIMGLRKWQFDIWSDDVTLA 437

  Fly   542 N---------------------LGEY----NNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRG 581
            |                     ||:|    .|..:.::....:.:..::  |:|.|
Worm   438 NHMESAGVPGAVHITKSTKDMLLGDYCIVDANTDDPHVVSYGQPTYHIL--PDKTS--------- 491

  Fly   582 NIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLAN 646
            .|.....|::.| .::.|...:.::..:.:...::.|.||.|...:   ||......|.:..|..
Worm   492 AIERTASIYRNS-RLSTSPALQSRMSMKAKVSKMVEFWGAETPFAN---FTKKKFSASHDPALIT 552

  Fly   647 EDLHLDHMFISSLVSDILKGMIYLHDSEI--ISHGNLRSS-NCLIDSRWVCQISDFGLHELKAGQ 708
            :::.....:|:::.|      :.|.::.:  .|..|:.|. ||                ||....
Worm   553 DEIARRPTYINTIPS------MTLIENNLTNFSFNNINSMFNC----------------ELPTIP 595

  Fly   709 EEP-------------NKSELELKRALCM----APELLRDAYRPGRGSQKGDVYSF----GILLY 752
            ..|             |.|:..|...:|:    |..||...|.|....|:..:..|    |:.:.
Worm   596 ASPKLLWPFSRKSITCNLSDCVLLTFVCIPSAFANLLLCSLYCPSDVLQQISLQQFFTIIGLAML 660

  Fly   753 EMIGRK---------------------GPWGDTAYSK-EEIIQF---VKCPEMLQHGV-----FR 787
            .::||.                     ||......|| |.::.|   :..|..:.|.|     :|
Worm   661 SLLGRVCSYAGPLITMVAFLLSSCIPIGPHIIIKKSKLEGVMAFNSLIFLPSCVSHLVSVFILYR 725

  Fly   788 PALTHTH---LDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKY- 848
              |.::|   |...|::                                   ||..:||:...|
Worm   726 --LPYSHRCFLFFADFV-----------------------------------IFQVLLSLFPAYG 753

  Fly   849 --------AYNLEGLVQERTNLL------------YEEKKKT--------------------DML 873
                    .|:| .:|....:||            ||.|:::                    .:|
Worm   754 AEVYVGYMGYHL-SVVSISLSLLVVLLFFIDWITNYERKRESACHVSFQNEERDVETMQDINKIL 817

  Fly   874 LYQMLPRPVAELLKRGDPVEAECF----DCVTILFSDIVGFTELCT---TSTPFEVVEMLNDWYT 931
            :..:||..||......|....|.:    :.|.::|:.|..|.:..:   |:...|.:.:||:...
Worm   818 IENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIPNFKDFWSEWDTNRKLECLRLLNEIVC 882

  Fly   932 CCDSIISN---YDVYKVETIGDAYMVVSG------------LPLQNGSRHAGEI---------AS 972
            ..|.::|.   ..|.|::|:|..||..:|            |..||..::...|         |:
Worm   883 EFDKLLSKPKFSSVEKIKTVGSTYMAAAGLNESEADYDDIYLEKQNSGKYNNNIRHGNMAFRNAN 947

  Fly   973 LALHLLETVGNL--KIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGD 1035
            |.:.....:..:  .:.....:..:||||:..||..|||:|.:.|:|.::|:|||.||||::.|:
Worm   948 LMIEFALAMSQILDALNRDSFQNFELRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRMDTHGE 1012

  Fly  1036 SMRIHISEATYQLLQVIGSYVCIERGLTSIKG-KGDMRTY 1074
            ..:||.:....::||. |.|....||...:|| |..|.|:
Worm  1013 PRKIHATTDMGRVLQT-GGYRVQSRGKIRVKGVKEPMETF 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	29/200 (15%)
		ANF_receptor	59..427	CDD:279440	29/179 (16%)
		PHA02988	534..826	CDD:165291	63/375 (17%)
		PK_GC-A_B	550..832	CDD:270944	54/338 (16%)
		HNOBA	<847..886	CDD:285003	14/79 (18%)
		CYCc	865..1057	CDD:214485	59/244 (24%)
		Guanylate_cyc	892..1076	CDD:278633	58/217 (27%)
acy-2	NP_504553.1	CYCc	253..463	CDD:214485	53/312 (17%)
		Guanylate_cyc	308..459	CDD:278633	42/243 (17%)
		CYCc	817..1034	CDD:214485	57/217 (26%)
		Guanylate_cyc	840..1054	CDD:278633	57/213 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900