DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and phlp-2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	918	Identity:	150/918 - (16%)
Similarity:	286/918 - (31%)	Gaps:	325/918 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RLTDTINIGFLAE------------YSQMRVTLGGLPLAIEDVNKNPNLLP-------------G 78
            |...|:|:..|:|            :...|.......:.::..|.....|.             |
Worm   131 RAKSTLNLDILSEEVVIRKGKLIHTWQNARAVFYNSNIRLQTKNNQDEALQIRNMKVDVHESKRG 195

  Fly    79 KKLAFKPVDIGHKMSAYRVKPLRA-MTQMREAGVTAFI-GPDESCT--TEALLASAWNTPMLSFK 139
            :.|..|..|:.:.:...|...|.| :|:.::...:..: ..||..|  .|.:|.:.....:|:.:
Worm   196 RALRLKDDDVCYLIIFQRPNILEAWLTRAQQVEKSNHVDASDEQLTLIPEQILNNEARVQILNLR 260

  Fly   140 CSDPIVSNKSTFHTFARTLAP-------------------ASKVSKSVISLLNAFHWNKFSI--- 182
             .:.::|...|    .:::||                   |:::....|.|....|..:.::
Worm   261 -RNSLISRPPT----EKSMAPLGYIDDLYRVHSLQVIDLSANQILSFPIQLTLLSHLRQLNLSSN 320

  Fly   183 VVSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEE--------TYATT 239
            .:||.|...|:: |.:|.|    |.:.:....:.|.|...:.|..:|....:        .:.|.
Worm   321 YISSVPSECSNM-RRLQYL----NLSNNQLDTLPDSISELQNLQSLDISFNQFSQIPPCLFHLTL 380

  Fly   240 RIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKS 304
            .::...|.:|..:|.|..:|.::         :.:...:.|::.|::|....:||  :|.....|
Worm   381 EMWRLAGNNIEKIDRVGEMQIQK---------IDLRRNVLDTSFRLDIENITHLD--LRDNSMIS 434

  Fly   305 ---LDKISFRSVIK-----------------------------ISMTYPQN--------PHIRDI 329
               |..:.|..||.                             :.|..|||        .|.|::
Worm   435 TVHLTNLRFLKVIHCERLQLSSLHLSGESLTHVYADHNLLDSLVVMPLPQNLQTLSLSFNHFRNL 499

  Fly   330 CSKIKDYARKT------PFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGN 388
            ...|.|....|      ..||...:|:|.:.|:        .|:..::..|.
Worm   500 PDWISDCPNLTFLRANNNSLVALPERIFYSQSL--------RSIFAFINEIE------------- 543

  Fly   389 LVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKN 453
                               :|...|:.....|:|..:|            |:|..|..||
Worm   544 -------------------HIPDFGEENCLETLILYKN------------KLSSLPKHFF----- 572

  Fly   454 SVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALLIK 518
            |::|..|.:.                 :.....||.|       |......|.|    .|.....
Worm   573 SILPRLRQLN-----------------ISSNFIELLP-------YFDGSSFCRL----QILRCAN 609

  Fly   519 HYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGNI 583
            :|..|.::..:   |:||.:.:|:|.  :|..|                    ||.:.||  .::
Worm   610 NYLTENSVPVI---VNMKHLKIIDLS--HNRLN--------------------SFDDSAL--SSL 647

  Fly   584 VAMKKIHKKSVDITR-----SIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDV 643
            ..::.::..|..:||     ::...|:::|.               |.:.::        .:.:.
Worm   648 ELLEDLNLSSNRLTRLADCLALLPCLQVLRA---------------HSNQLV--------HVPEF 689

  Fly   644 LANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQ 708
            .|:..||         ..|:....|.|...:..:..|||..:.      .|...||.....
Worm   690 RASNQLH---------TIDVSSNNISLGTLQFKAPPNLRHFDV------TCNSGDFDTENF---- 735

  Fly   709 EEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKG-------------- 759
              |..:::..|          .:......|||  :::.|.|.:....|.|.
Worm   736 --PENAKMHSK----------MNTINISEGSQ--NLFGFQIGVSGSRGMKNKQCIRQVRVENTFG 786

  Fly   760 --PWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLV 822
              ..|..:|....|.:|:  ...|:..|        .:||...:.:|.|:..:|...:...:.::
Worm   787 FIDGGSNSYMSSSICRFM--TSYLKENV--------SMDIRSILLRCHCELGEEGERLGASVMII 841

  Fly   823 RMHLKELQ 830
            |:|.|.|:
Worm   842 RVHEKRLE 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	81/508 (16%)
		ANF_receptor	59..427	CDD:279440	73/460 (16%)
		PHA02988	534..826	CDD:165291	49/312 (16%)
		PK_GC-A_B	550..832	CDD:270944	47/302 (16%)
		HNOBA	<847..886	CDD:285003
		CYCc	865..1057	CDD:214485
		Guanylate_cyc	892..1076	CDD:278633
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	5/20 (25%)
		leucine-rich repeat	254..288	CDD:275380	5/38 (13%)
		PLN00113	283..>718	CDD:331614	94/594 (16%)
		leucine-rich repeat	289..311	CDD:275380	3/21 (14%)
		leucine-rich repeat	312..334	CDD:275380	4/22 (18%)
		leucine-rich repeat	335..357	CDD:275380	5/25 (20%)
		leucine-rich repeat	358..379	CDD:275380	2/20 (10%)
		leucine-rich repeat	380..440	CDD:275380	13/70 (19%)
		leucine-rich repeat	441..485	CDD:275380	5/43 (12%)
		leucine-rich repeat	486..508	CDD:275380	4/21 (19%)
		leucine-rich repeat	509..534	CDD:275380	6/32 (19%)
		leucine-rich repeat	554..577	CDD:275380	9/39 (23%)
		leucine-rich repeat	578..602	CDD:275380	6/47 (13%)
		leucine-rich repeat	603..625	CDD:275380	5/24 (21%)
		leucine-rich repeat	626..649	CDD:275380	8/46 (17%)
		leucine-rich repeat	650..672	CDD:275380	3/21 (14%)
		leucine-rich repeat	673..694	CDD:275380	4/43 (9%)
		PP2Cc	754..985	CDD:214625	21/108 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900