DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and gcy-20

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_507101.1	Gene:	gcy-20 / 184797	WormBaseID:	WBGene00001545	Length:	1108	Species:	Caenorhabditis elegans

Alignment Length:	1157	Identity:	342/1157 - (29%)
Similarity:	513/1157 - (44%)	Gaps:	181/1157 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ILVLL----LLGCQRSNPLAAGATVSSMRRLTDTINIGFLAEYSQMRVTLGGLPLAIEDVNKNPN 74
            ||:||    |:.||....:..|...|.     ||.::.....|.    |.....|..:|..:..:
Worm     3 ILLLLLQNILVFCQFLQTIKVGLMFSK-----DTASVIRSVGYR----TSAAAVLVAKDRIRAEH 58

  Fly    75 LLPGKKLAF--KPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGP--DESCTTEALLASAWNTPM 135
            ||......|  |..:....::|.:|..|     :....|...|||  :.:....|.||..:|.|:
Worm    59 LLDQYDFNFTIKFDECSESLAAGKVVEL-----LTHDNVDVIIGPTCNRAGVAVASLADFYNVPV 118

  Fly   136 LSFKCSDPI-VSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSS------------- 186
            ..:..:... :.|.|.:.|..........:|.:|..:|..:.|::|..:.|:
Worm   119 FQWGLTTTADIGNFSRYQTTVTLSLDTHSISLAVREILRQYGWSEFVFIYSNDGDEEKCAAMKDD 183

  Fly   187 ---KPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDK---IIEETYATTRIY--V 243
               ..|..|||..|.  :.:.:..|:...:         :||.::.|   ||...:|:.|.:  .
Worm   184 MEKMGIENSDVTMAY--MIQIQTVTMESLQ---------RTLLEVSKRGRIIIACFASGRGFKKA 237

  Fly   244 FIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSK---SL 305
            ||...:     :.|:...      :|:.|..:.:           .|.:   |:.:...|   |.
Worm   238 FIASTV-----LAGMSTE------EYLYVFAEPQ-----------SRGF---YVDEADGKVHYSW 277

  Fly   306 DKISFRSVIKISMTYPQNPHIRD-------ICSKIKDYARKTPFLVPYHQRVFDNIS-------- 355
            |....:.|..::     |..|||       ||..:.:....|.....:..:|...::
Worm   278 DDTDGQLVTGLT-----NEQIRDAYGKVLYICDNMGEPTTITTQYTNFTSQVISRMAEQPFNCVQ 337

  Fly   356 ---------VPIYGLHLYDSVMIYVRAITEVLR---LGGDIYDGNLVMSHIFNRSYHSIQGFDVY 408
                     ...|...|.||...|..|:.:.|.   ...::.:|:.|:|:| ..::..:.|..|.
Worm   338 DCSNQSYKHAATYAGQLADSFYAYAFALNKSLTQDPTRSNLKNGSFVLSNI-GMTFQGVGGEAVT 401

  Fly   409 IDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNG 473
            :|.:|.......:..:.:.:....:...|..:|  .|.|..:.|:.  .|...::
Worm   402 LDESGSRIVQVYMFAMNSSLLPYMAASLLVNVS--EVVFTPFYKSE--SELWSVR---------- 452

  Fly   474 RPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAI------ALLIKHY-RYEQTLAGLLW 531
              ||:.|.|||.|..||...:. .|||...:.|.:|::|:      .|...|. |.|.....|||
Worm   453 --PLSRPKCGFTGLECPADFVK-EYLVYTIIAAFIVILALLAGCAGLLYTMHMKRKEMERQDLLW 514

  Fly   532 KVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIAL--FRGNIVAMKKIHKKSV 594
            :|...::..:. .:.....:.:.|.....:...:...::...||...  :...:||.|| |...|
Worm   515 QVAFVELQQVQ-SKSRAEASMHSFASGPSTSTKMTVESRTETTNFIFYHYHQEVVAAKK-HDLLV 577

  Fly   595 DITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSL 659
            ....:.:.|.:.||...::|:..|||...|...::....:|:||||.||::...:.:|..|:.||
Worm   578 LFDANQKSEFRQMRNFDNDNLNKFIGLCLDGPQLLSLWRFCSRGSLSDVISKSSMQMDSFFMFSL 642

  Fly   660 VSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCM 724
            :.||..|:.::|.|.:..||.|.|..||||.||..:||.|||..::. .|.|.|.:|     |..
Worm   643 IRDISNGLYFIHSSFLKCHGQLTSRCCLIDDRWQIKISGFGLKSVRT-FENPKKEDL-----LWA 701

  Fly   725 APELLR--DAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEE---IIQFVK------CP 778
            :||.||  |..|    ..:||:|||||:..|::.|...: |....||:   ||..||      ..
Worm   702 SPEYLRNEDQER----LPEGDIYSFGIICAEILTRSSAF-DLENRKEKPDVIIYQVKKGGHNPTR 761

  Fly   779 EMLQHG---VFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDN 840
            ..|..|   |..|||.|...|           ||.|.|..||.|..||.||..::.|.|.|:.|:
Worm   762 PSLDTGETVVINPALLHLVRD-----------CWTERPSERPSIEQVRSHLNGMKDGRKTNLMDH 815

  Fly   841 MLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFS 905
            :.:::|.||..||..|.:||..|.|||||:|:|||:||||.||:.||.|..||.|.|:.|||.||
Worm   816 VFNMLETYASTLEEEVSDRTKELTEEKKKSDVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFS 880

  Fly   906 DIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEI 970
            |:|.||.|....||.:||.:|||.||..|.||...||||||||||.|:.|||||.:||:.|...|
Worm   881 DVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNDHIRHI 945

  Fly   971 ASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGD 1035
            |.::|..|.::...:::|.|.|.:.||||::.|...|||||..|||||||||.|||||||||.|.
Worm   946 ARMSLGFLSSLEFFRVQHLPAERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGK 1010

  Fly  1036 SMRIHI-SEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQQPELTP 1086
            ..:||: :||...|.||:|.:....||...|||||.|.|:||...:.....|
Worm  1011 PGQIHVTAEANRMLTQVVGGFRTESRGEVIIKGKGVMETFWLLGEESGYTAP 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	79/459 (17%)
		ANF_receptor	59..427	CDD:279440	74/423 (17%)
		PHA02988	534..826	CDD:165291	92/307 (30%)
		PK_GC-A_B	550..832	CDD:270944	94/297 (32%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	107/192 (56%)
		Guanylate_cyc	892..1076	CDD:278633	98/184 (53%)
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347	83/474 (18%)
		ANF_receptor	44..418	CDD:279440	74/420 (18%)
		PKc_like	536..801	CDD:304357	92/287 (32%)
		STYKc	562..801	CDD:214568	89/261 (34%)
		HNOBA	<818..861	CDD:285003	24/42 (57%)
		CYCc	840..1032	CDD:214485	107/191 (56%)
		Guanylate_cyc	867..1054	CDD:278633	100/186 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920