Protein Alignment Gyc32E and gcy-11

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001359843.1
• Gene: gcy-11 / 181745
• WormBaseID: WBGene00001537
• Length: 1168
• Species: Caenorhabditis elegans
• Alignment Length: 1090
• Identity: 340/1090 - (31%)
• Similarity: 533/1090 - (48%)
• Gaps: 141/1090 - (12%)

  Fly    88 IGHKMSAYRVKPLRAM--TQMREAGVTAFIGPDESCTTEALLASAWNTPMLSFKCSDPIVSNKST 150
            ||.:...|....|..|  ...:..|:...:|.:..|...|.||.|::...|...|.|.:..::..
 Worm    85 IGRQDGNYMSSMLDIMLADTKKNDGLLGVVGVENDCKEIAALAQAYDASSLLVNCEDQVGESQMP 149

  Fly   151 FHTFARTLAPASKVSKSVISLLNAFHWNKFSIV--VSSKPIWGSDVARAIQ--ELAEARNFTISH 211
            ..|..:..:......::...|..:..||..:::  |...|   :|::...|  :...|.:.::..
 Worm   150 SSTALQMSSTQGGKYRAFAKLAKSVGWNNLAVINFVEDGP---ADISYHDQLLDALSAESISLDF 211

  Fly   212 FKY--ISDYIPTTKTLSQIDKIIE---ETYATTRIYVFIGE-HIAMVDFVRGLQNRRLLESGDYI 270
            .|.  .|..| |:...:.::.:|:   |||..|||||.:.: .::...|:..:....|||:|.|.
 Worm   212 VKKGGFSSTI-TSAMFTGLESVIDVILETYMKTRIYVIVLDLPVSGTFFMNAMSTMGLLETGKYF 275

  Fly   271 VVSVDDEIYDSNRRVNIMERNYLDPYIRKEKS--KSLD----KISFRSVIKISMTYPQNPHI--- 326
            ||.:.....|:        .||....:.:...  |::|    ....|...:..|.:...||.
 Worm   276 VVMMSSIESDA--------ANYFGFNVNRGNMIFKTIDYGISDADIRQYYRSFMYFTDVPHYTKD 332

  Fly   327 -----------------RDIC-----SKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMI 369
                             :..|     :|.|..|...|:....:........|..|.|.
 Worm   333 FSDEWTSFQKRVDGDASKTFCPPMCNTKAKGIANNDPWSDDAYWYSESPSIVDAYDLG------- 390

  Fly   370 YVRAITEVLRLGGD--IYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGA 432
              |.::|.:::.|.  :.|...::..:..|...|:.|:....::||.::..|.:...|....|..
 Worm   391 --RLLSETVKVHGASLLRDPESLVQTMSGRGVTSLLGYVTKFNTNGVSQREYILWAPQQASSSNG 453

  Fly   433 SI-----GSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPR- 491
            .|     .:|| ..|.|.|...|   |:|     .||...:...||..|.::|.|||:.||||.
 Worm   454 PIPLPEWATLA-ARMLPDGKGNY---SII-----WKNLTQLGIFNGELPQSKPECGFNNELCPAG 509

  Fly   492 -KKLDWRYLVSGPLCA---LVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNK 552
             :.|....::...:|.   |::|..||.:.:...||:.|....:.|..|.|.::::.::.:....
 Worm   510 IRNLSELEIIVIAVCVVAILILVGVIAYIARWIAYERRLESSYFLVHRKHVQLVDMTKFGSSRGG 574

  Fly   553 NIFQICR------QSILVVGEPNKRSFTN---------------------------------IAL 578
            ::.|...      :....||......:||                                 :|.
 Worm   575 SMIQSAMSMRSQYEDSGPVGGATMNFYTNGIRKAAIRRNQMQRSDKGPAANRDEWLEIVDWHLAK 639

  Fly   579 FRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFT--TYCARGSLE 641
            :...:|.::||:|..:.:||.:::|:.|:....|||:..|.|...:  |.:|||  :|..|.||.
 Worm   640 YENTLVTVRKINKTQLKLTREMKQEIDLLMNETHENLNRFFGLINE--SDLIFTIHSYGPRKSLM 702

  Fly   642 DVLANEDLHLDHMFISSLVSDILKGMIYLHD-SEIISHGNLRSSNCLIDSRWVCQISDFGLHELK 705
            |:|.|:||.||.||..|.|.|::||:.:||: |:|..||||:||||::|:.|..::|::|:.:::
 Worm   703 DLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIR 767

  Fly   706 AGQEEPNKSELELKRALCMAPELLRD-AYRPGRGS---QKGDVYSFGILLYEMIGRKGPWGDTAY 766
            .  |||.....:|   |..|||::|. |.:.....   .|.|:||..|:|||:.||:||:||...
 Worm   768 V--EEPESKPDDL---LWFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLL 827

  Fly   767 SKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQA 831
            ..:|||:.:|.|:  ...:.||.: |.....|..:...:.:||.|||..||.|:.||..||.|..
 Worm   828 DSDEIIEQLKFPD--GGALTRPDI-HLITKAPYPLASVVEKCWVEDPASRPSIKKVRELLKPLSK 889

  Fly   832 GLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAEC 896
            |||.||.||:::::::|..|||.:::|||..|.:|:|:.:.||.|:||:.||..||.|.||:||.
 Worm   890 GLKGNIADNIMNLLDRYRNNLEDVIKERTEQLEDERKRNESLLLQLLPKSVANSLKNGQPVDAEF 954

  Fly   897 FDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQ 961
            :|.|:|.||||||||.|.:.|||.:||.|||:.||..|:||..:|.|||||||||||.|||||..
 Worm   955 YDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEV 1019

  Fly   962 NGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNT 1026
            |...||||:||.:|.||:::....:.|.|.|.::||||.|:||...||||.:|||||||||||..
 Worm  1020 NSYLHAGEVASASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVII 1084

  Fly  1027 ASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076
            |:.|||:|:.|||.||...|:|:...|.||..:|....:|.|.::.|||:
 Worm  1085 ANMMESSGEPMRIQISSDAYELILKCGGYVTEQREKIVLKNKLEVMTYWM 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	80/409 (20%)
		ANF_receptor	59..427	CDD:279440	73/383 (19%)
		PHA02988	534..826	CDD:165291	102/337 (30%)
		PK_GC-A_B	550..832	CDD:270944	103/327 (31%)
		HNOBA	<847..886	CDD:285003	17/38 (45%)
		CYCc	865..1057	CDD:214485	107/191 (56%)
		Guanylate_cyc	892..1076	CDD:278633	100/183 (55%)
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651	44/234 (19%)
		PKc_like	640..890	CDD:389743	97/259 (37%)
		CYCc	923..1116	CDD:214485	108/192 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920