Protein Alignment Gyc32E and gcy-18

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 1103
• Identity: 319/1103 - (28%)
• Similarity: 511/1103 - (46%)
• Gaps: 228/1103 - (20%)

  Fly   111 VTAFIGPDESCTTEAL--LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAP-ASKVSKSVISLL 172
            |.|||||..:...||:  :|:.||.|::|:......||::|.:.|.||..:. .:.::::.::||
 Worm   117 VRAFIGPYCAAELEAVTKMATFWNIPIISYSSVPNAVSDRSVYKTLARVSSKNTNSIAEATVALL 181

  Fly   173 NAFHWNKFSIVVSSKPIWGSDVARAI---QELAEARNFTI------------------------- 209
            ..:.|.|.:|..::    ||.....:   :|:......||
 Worm   182 LHYKWLKVAIATNT----GSTAFERVSIFEEIMHREGVTIVKKVMFDENTDANEMMNSGQLGDLA 242

  Fly   210 SHFKYISDYIPTTKTLSQIDKIIEETYATTRI----YVFIGEHIAMVDFVR----------GLQN 260
            ::.:.|.....:||.||:  :.::.|| |.|:    |.:|      :.:::          |...
 Worm   243 ANARIIICLFSSTKELSK--EFMQATY-TMRMNNAEYAYI------IPWLQSGTKDLTPWIGADG 298

  Fly   261 RRLLESGDYI--VVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQN 323
            ..|....|:.  .:.|||        ||..:.:.:..::.|.:...:.|
 Worm   299 EMLQRVKDHYANAIIVDD--------VNGFDDSVVSSFVEKIEKHGMQK---------------- 339

  Fly   324 PHIRDI-CSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVL-RLGGDIY- 385
               .|| .:.|..|                        |||:||:.:|..||.:|| ....:.|
 Worm   340 ---SDIDVTNINGY------------------------LHLFDSLKLYALAIRKVLNETDNEAYV 377

  Fly   386 -DGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMS------MQ 443
             :|..:.:.:....:..:.... ..:.|.||....||  |.:||...|.|.|...:|      |:
 Worm   378 TNGQFIWNRMRRMKFEGVVSRS-SSEENKDAGAIGTV--LMDDVADRAPIFSAFYISPNRDKVMK 439

  Fly   444 PVGFFAYDKNSVIPEFRYIKNDRPIQWL-------------NGRPPLAEPLCGFHGELCPRKKLD 495
            .|..    ::.:|.....:||......|             :|..||.||:||:.|:.|
 Worm   440 MVNM----ESELISNCDGLKNKSGCFQLKINDIKSGFWPSEDGSMPLDEPICGYRGQRC------ 494

  Fly   496 WRYLVS---GPLCALVVVVAIALLIKHYRY--EQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIF 555
             .||:.   |.|..|::::::..... :||  .:.|..:.|::...|:..|:..:.
 Worm   495 -SYLLEISVGSLIILLILISVVFFFL-FRYCENKQLEKMPWRIFHDDLQFIDEEQV--------- 548

  Fly   556 QICRQSILVVGEPNKRSFTNI-------ALFRGNIVAMKKIHKKSVDITRSIRKELKL---MREV 610
                :|::.||....: .:||       |:...|.......:|:...| :.|:::::|   |::.
 Worm   549 ----KSMMSVGSVTTK-LSNIQTGQKQHAIIGVNTHTTYHRYKQRRPI-KFIKEDMQLLTQMKQA 607

  Fly   611 RHENIINFIGAS-TDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSE 674
            .|:|:..|:||: .:...:::...:|:||:::|::.|.::.||..|..:.|.||..|:.|||.|.
 Worm   608 VHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVRDITLGLEYLHASP 672

  Fly   675 IISHGNLRSSNCLIDSRWVCQISDFGLH------------ELKAGQEEPNKSEL-ELKRALCMAP 726
            |..||:|....||||..|:.::||:|:.            |:.|.::..:||:. :....:.|||
 Worm   673 IGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAAKDSDDKSQASQATSIIYMAP 737

  Fly   727 ELLRDAYRPGRGS-------------QKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVK-- 776
            |||::.....|..             |.||:||||:::||::.|..|:.|.. :..|::.::.
 Worm   738 ELLKNRETNKRRGMDQSWVKQSMLRRQAGDIYSFGMVMYEILFRSLPFRDNT-NISELVDYLADG 801

  Fly   777 ----CPEML-QHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPN 836
                .||:. |.|:        |.|:...:|    .||.|:||:||.||.||:: .|:....|.:
 Worm   802 SKTVSPEIQNQMGL--------HPDLNALLR----DCWSENPEIRPSIRRVRLN-TEMVLKTKGS 853

  Fly   837 IFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVT 901
            :.|.|:.:||:||.|||.||.|||.:|.|...:.|.||.|:||..||..||.|..|..:.:...|
 Worm   854 LVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSAT 918

  Fly   902 ILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRH 966
            ||||||||||.:|:.|||.|||.|||..||..|..|:....|||||||||||||||:|.:|...|
 Worm   919 ILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAYMVVSGIPEENEYNH 983

  Fly   967 AGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRME 1031
            :..||:.||.:.:.:...:|.|:||..|:.|.|.|:|..||||||...|||||||||||.:||||
 Worm   984 SRNIANTALDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRME 1048

  Fly  1032 STGDSMRIHISEATYQLLQVIGS-YVCIERGLTSIKGKGDMRTYWLTKRQQPELTPDLISTVD 1093
            |||....|.:||..:..::.... :...|||...:||||..||:||..|.....|.:.|..|:
 Worm  1049 STGTPGMIQMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWLEDRVGDASTTNYIQNVE 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	80/393 (20%)
		PK_GC-A_B	550..832	CDD:270944	88/325 (27%)
		CYCc	865..1057	CDD:214485	96/192 (50%)
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575	80/399 (20%)
		Protein Kinases, catalytic domain	549..846	CDD:473864	87/312 (28%)
		CYCc	882..1073	CDD:214485	96/190 (51%)