Protein Alignment Gyc32E and gcy-29

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001364597.1
• Gene: gcy-29 / 175116
• WormBaseID: WBGene00007314
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 1053
• Identity: 285/1053 - (27%)
• Similarity: 495/1053 - (47%)
• Gaps: 170/1053 - (16%)

  Fly   111 VTAFIGPDESCTTE----ALLASAWNTPMLSFKCSDPIVSNKSTFHTFART-LAPASKVSKSVIS 170
            |.|:.||  .|:.|    |.:||.||.|:.::..:....:|...:.|..|| ....:.:|::..:
 Worm    93 VDAYFGP--YCSKELSPVATMASYWNIPIFAYTATSAEFANTKVYKTLLRTSFQSLNSISEATAA 155

  Fly   171 LLNAFHWNKFSIVVSSKPIWGSDVARAIQELAEA---RNFTISHFKYISDYIPTTKTLSQIDKII 232
            .:...:..|.:||.:.    |:|....||.|.:|   |..|::.                  :::
 Worm   156 FMAHHNITKAAIVANI----GTDSFEKIQSLEKALRSRGITVAR------------------RVM 198

  Fly   233 EETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERN------ 291
            .|..|:.:         .:||  .|..|.  |.....:::    .|:.|.|.::.:.||
 Worm   199 FEEAASAQ---------DLVD--NGYMNE--LRDNARVIL----PIFSSTRDLSTVFRNATWLAN 246

  Fly   292 -------YLDPYIRKEKSKS----LDKISFRSVIKISMTYPQNPHIRDICSKI---KDYARKTPF 342
                   |::|.|....|:.    ..|::.:|:      ..:||:...|.:..   .|...:...
 Worm   247 MASPEFIYINPLIVARNSEEPPVFYGKMAQKSI------KAENPNTIQIYNSYGFSDDLLNEFLA 305

  Fly   343 LVPYHQRVFDNISVPIYGLHLYDSVMI-------YVRAITEVLRLGGDIYDGNLVMSH------- 393
            :...:||::.:.......:.||:|..:       |:.::.|....|....||..:.:.
 Worm   306 IFDQNQRIYIDEKDLFNYVALYESFCVFAKLTEKYLHSLKEKPEDGKIRIDGKALWNMAVGMTFQ 370

  Fly   394 ------IFNRSYHSIQGFDV-YIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYD 451
                  ||:.....:..|.. |:|...|   ....::|.|...:       :|..|.|| .....
 Worm   371 GVLDNVIFDNGAERMTSFSAFYVDEKRD---QIRTVSLINSTVT-------SKNCMDPV-CIELV 424

  Fly   452 KNSVIPEFRYIKNDRPIQWL--NGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIA 514
            .:.|:.:|          |.  :|:.|.:||.|||..|.|...:   ..:::..:..:::.|.:.
 Worm   425 VSDVVTKF----------WSSPSGKLPDSEPECGFREENCDYTQ---TIVIATAVVCIILTVFLG 476

  Fly   515 LLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALF 579
            :.::.......|..:.|:|...||.:::..:..:..:.|      .:...:.:...:...|.|:.
 Worm   477 IWLRRACETSALDKMPWRVFRDDVQILDEEQVKSVVSLN------SASTKMSQVETKLIKNHAIV 535

  Fly   580 RGNIVAMKKIHKKSVDITRSIRKELKL---MREVRHENIINFIGAS-TDHGSVIIFTTYCARGSL 640
            ..|..|:..::::..:| |..|::|.|   |::..|:||..|||.| .:...:::...:|:||:|
 Worm   536 GVNTHAVYDLYEQRQNI-RFTREDLILLTKMKQAVHDNINPFIGVSFNEKSELLLLWKFCSRGTL 599

  Fly   641 EDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHE-L 704
            :||:..|...:|..|..:.|.||..|:.|||.|.|..||.|...:.|||..|:.:::|:.:.: |
 Worm   600 QDVIYCEKFAMDEKFQGAFVRDITMGLEYLHSSPIGYHGGLACWSVLIDKNWMLKLTDYAVCDPL 664

  Fly   705 KAGQEE-------PNKSELELKR--ALCMAPELLRDAYRPGR--------------GSQKGDVYS 746
            |..::.       .|::|.:.::  :|.:.|| :|.|....|              ..|:.|:|:
 Worm   665 KRWEKHGRINCKVDNEAEKQWQKMASLYVPPE-IRTANEKNRLKRMDQKWQGQTILKRQQSDIYA 728

  Fly   747 FGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHG--VFRPALTHTHLDIPDYIRKCLCQCW 809
            ||:::||::.|..|:       :|.:...:..:....|  :.:|::.......||.| ..|..||
 Worm   729 FGVIIYEILFRSLPY-------DEKVDLTELAQKAAEGDKIQKPSIQRNKKLNPDLI-ALLQDCW 785

  Fly   810 DEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLL 874
            .:.|::||.||.||: ..|:....|.|:.|:|:.:||:||.|||.||.|||.|..|...:.:.||
 Worm   786 SDQPDMRPTIRRVRL-ATEIALKTKGNLVDSMMRMMEEYANNLEKLVGERTKLAEEANLRAERLL 849

  Fly   875 YQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISN 939
            :|:||:.||..||.|..|..:.:|..|::||||||||:||:.|||.|||.:||..|:..|::||.
 Worm   850 FQLLPKHVAIELKAGRTVAPKMYDSATVMFSDIVGFTKLCSASTPIEVVNLLNKLYSEFDTVISK 914

  Fly   940 YDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGP 1004
            :|.|||||||||||||||:|::||.||...|:::.|.:::.:...::.|:....:.:|:|..||.
 Worm   915 HDCYKVETIGDAYMVVSGIPIENGQRHVANISAVTLGIMDLLKVFEVPHRRDYRLTIRLGFASGQ 979

  Fly  1005 CAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGK 1068
            .:|.|||...|||||||:|||.|:.|||:|:..|:.|:|.:..||:.......|| ||:.....:
 Worm   980 VSAAVVGLSSPRYCLFGETVNIAAVMESSGEGGRVQITETSKILLENEYPEFIIEIRGINKDVKQ 1044

  Fly  1069 GDMRTYWLTKRQQ 1081
            .|..|||||.:.:
 Worm  1045 DDFVTYWLTGKDE 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	72/385 (19%)
		PK_GC-A_B	550..832	CDD:270944	80/311 (26%)
		CYCc	865..1057	CDD:214485	88/191 (46%)
gcy-29	NP_001364597.1	PBP1_NPR_GC-like	27..403	CDD:380575	66/359 (18%)
		Protein Kinases, catalytic domain	534..804	CDD:473864	76/280 (27%)
		CYCc	840..1033	CDD:214485	88/192 (46%)