Protein Alignment Gyc32E and Gucy2e

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_036012232.1
• Gene: Gucy2e / 14919
• MGIID: 105123
• Length: 1139
• Species: Mus musculus
• Alignment Length: 1184
• Identity: 355/1184 - (29%)
• Similarity: 554/1184 - (46%)
• Gaps: 220/1184 - (18%)

  Fly     1 MPGPCASAAAFSCILVLLLLGCQRSNPLAAGATVSSMRRL-TDTINIGFLAEYSQMRVTLGGLPL 64
            :|.|.|.:|.|.    :.:||....:|:.|.|......|| .:.:|..|         .|.|.|.
Mouse    47 LPSPSALSAVFK----VGVLGPWACDPIFARARPDLAARLAANRLNRDF---------ALDGGPR 98

  Fly    65 AIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGP--DESCTTEALL 127
            ....:...|.|.||        .:|...||.             :.|:..:||  ..:|....||
Mouse    99 FEVALLPEPCLTPG--------SLGAVSSAL-------------SRVSGLVGPVNPAACRPAELL 142

  Fly   128 ASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPA-SKVSKSVISLLNAFHWNKFSIVVSSKPIWG 191
            |......::.:.|...         ..|.|.||| :..:.::..||.||.|.:.:::.:.:.:|
Mouse   143 AQEAGVALVPWGCPGT---------RAAGTTAPAVTPAADALYVLLRAFRWARVALITAPQDLW- 197

  Fly   192 SDVARAIQELAEARNFTISHFKYI--SDYIPTTKTLSQI-------------------------D 229
            .:..||:.....||...::....:  ||.....:.|.:|                         .
Mouse   198 VEAGRALSTALRARGLPVALVTSMETSDRSGAREALGRIRDGPRVRGKLPSRVRARWVGPAESGQ 262

  Fly   230 KIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEI----YDSNRRVNIMER 290
            :....:.:.....|.:..|..::.   |.:.|.|||:.:.:.:: |..:    :|:.........
Mouse   263 RSEPASVSVRSAVVIMVMHSVLLG---GEEQRYLLEAAEELALT-DGSLVFLPFDTLHYALSPGP 323

  Fly   291 NYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNIS 355
            ..|..::...:.:.    :..:|:.::...|....::|...:.::           ||.:..:::
Mouse   324 EALAAFVNSSQLRR----AHDAVLTLTRRCPPGGSVQDSLRRAQE-----------HQELPLDLN 373

  Fly   356 V----PIYGLHLYDSVMIYV----RAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGF------- 405
            :    |::|. :||:|.:..    ||.|.|   ||....|..|...:...   .:.||
Mouse   374 LKQVSPLFGT-IYDAVFLLAGGVKRARTAV---GGGWVSGASVARQVREA---QVSGFCGVLGRT 431

  Fly   406 ----DVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDR 466
                .|.:|::...|..:....|...:||..|.|:
Mouse   432 EEPSFVLLDTDASGEQLFATHLLDPVLGSLRSAGT------------------------------ 466

  Fly   467 PIQWLNGRP-PLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALLIKHYRYE----QTL 526
            |:.:..|.| |..:|.|.|..::.....::...:..|.|..:.:.:..|.|..:.|:.    |..
Mouse   467 PMHFPRGGPAPGPDPSCWFDPDVICNGGVEPGLVFVGFLLVIGMGLTGAFLAHYLRHRLLHMQMA 531

  Fly   527 AG---LLWKVDMKDVTVINLGEYNNP---TNKNIFQICRQSILVVGEPNKRSF-------TNIAL 578
            :|   ::  :.::|||.:      :|   :::.:.|..|.|:......:.||.       ||:.|
Mouse   532 SGPNKII--LTLEDVTFL------HPPGGSSRKVVQGSRSSLATRSASDIRSVPSQPQESTNVGL 588

  Fly   579 FRGNIVAMKKI-HKKSVDITRSIRKELKLMREVRHENIINFIG----------ASTDHGSVIIFT 632
            :.|:.|.:||. .:..:.|..:.:.....:||:||||:..::|          |:...|.:.:.:
Mouse   589 YEGDWVWLKKFPGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVS 653

  Fly   633 TYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQIS 697
            .:||||||.|:||..::.||.||.|||:.|::|||.|||... ::||.|:|.||::|.|:|.:::
Mouse   654 EHCARGSLHDLLAQREIKLDWMFKSSLLLDLIKGMRYLHHRG-VAHGRLKSRNCVVDGRFVLKVT 717

  Fly   698 DFGLHELKAGQE---EPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKG 759
            |.|...|...|.   ||..:|.:    |..|||||||.....||:..|||:|..|::.|::.|..
Mouse   718 DHGHGRLLEAQRVLPEPPSAEDQ----LWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRST 778

  Fly   760 PWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKC---LCQCWDEDPEVRPDIRL 821
            |:.....:.||:||.|:.|         |.|....:.:.....:|   :.|||.|.||:||.:.|
Mouse   779 PYAMLELTPEEVIQRVRSP---------PPLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDL 834

  Fly   822 VRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELL 886
            .....|.:..|.|.||.|:||.::|:|:.|||.|::|||..|.:||:|||.||.||||..|||.|
Mouse   835 TFDLFKSINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEAL 899

  Fly   887 KRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDA 951
            |.|..||.|.|:.||:.||||||||.:...|.|.|||::|||.||..|:||..:|||||||||||
Mouse   900 KMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDA 964

  Fly   952 YMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPR 1016
            |||.||||.:||.|||.|||:::|.:|..||:.::||.|...|::|||:|||||.|||||..|||
Mouse   965 YMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPR 1029

  Fly  1017 YCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWLTKR- 1079
            ||||||||||||||||||...|||::.:|.::|:.:.....:| ||.|.:||||...||||..|
Mouse  1030 YCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRL 1094

  Fly  1080 -------QQPELTP 1086
                   :.|:|.|
Mouse  1095 GFNKPIPKPPDLQP 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	77/456 (17%)
		PK_GC-A_B	550..832	CDD:270944	98/305 (32%)
		CYCc	865..1057	CDD:214485	117/191 (61%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	83/476 (17%)
		PK_GC-2D	570..845	CDD:270945	95/288 (33%)
		HNOBA	<854..899	CDD:462234	26/44 (59%)
		CYCc	879..1070	CDD:214485	117/190 (62%)