Protein Alignment Gyc32E and Gucy2d

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001124165.1
• Gene: Gucy2d / 14918
• MGIID: 106030
• Length: 1117
• Species: Mus musculus
• Alignment Length: 1121
• Identity: 366/1121 - (32%)
• Similarity: 545/1121 - (48%)
• Gaps: 188/1121 - (16%)

  Fly    42 DTINIGFLAEYSQMRVTLGGLP-----LAIEDVNKNPNLLPGKKLAFKPVDIG----HKMSAYRV 97
            :|..:|.|..:....:....||     ||::.||::.:||||.:|.||.:..|    |.::.:
Mouse    68 ETFTLGVLGPWDCDPIFAQALPSIATQLAVDQVNQDASLLPGSQLDFKVLPTGCDTPHALATF-- 130

  Fly    98 KPLRAMTQMREAGVTAFIGPDES--CTTEALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAP 160
                   ...:..|.||:||...  |:..||||..|...:.|:.|..|....     ....||..
Mouse   131 -------VAHKNIVAAFVGPVNPGFCSAAALLAQGWGKSLFSWACEAPEGGG-----DLVPTLPS 183

  Fly   161 ASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTL 225
            |:.|   ::|::..|.|.:::||.|.:.||    ....|:||.|..........::...|..|..
Mouse   184 AADV---LLSVMRHFGWARWAIVSSHQDIW----VTTAQQLATAFRTHGLPIGLVTSLGPGEKGA 241

  Fly   226 SQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLE--------SGDYIVVSVDDEIYDSN 282
            :::.|.:...:...  .|.:..|.|::.   ||:...||.        .|..:.:..|..::
Mouse   242 TEVCKQLHSVHGLK--IVVLCMHSALLG---GLEQTTLLHCAWEEGLTDGRLVFLPYDTLLF--- 298

  Fly   283 RRVNIMERNYLDPYIRKEKSKSLD-----KISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPF 342
             .:....|:||          .||     :.::.:|:.:|:......|   ..:..:.....|..
Mouse   299 -ALPYGNRSYL----------VLDDHGPLQEAYDAVLTVSLESSPESH---AFTATEMSGGATAN 349

  Fly   343 LVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYH----SIQ 403
            |.|      :.:| |::|. :||:|::...|:..     .:.:...|..:|:.:   |    .:.
Mouse   350 LEP------EQVS-PLFGT-IYDAVILLAHALNR-----SETHGAGLSGAHLGD---HVRALDVA 398

  Fly   404 GFDVYIDSNGDAEGNYTVITLQNDVGSGAS-----IGSLAKMSMQPVGFFAYDKNSVIPEFRYIK 463
            ||...|.::|........:.|..| |.|:.     |...:...:||:|
Mouse   399 GFSQRIRTDGKGRRLAQYVILDTD-GEGSQLVPTHILDTSTWQVQPLG----------------- 445

  Fly   464 NDRPIQWLNGRPPLAEPLCGFH-GELCPR--KKLDWRYLVSGPLCALVVVVAIALLIKHYRYEQT 525
              :||.:..|.||..:..|.|. ..||.|  :.|       |.|..|.:...:||:.....|
Mouse   446 --KPIHFPGGSPPAHDASCWFDPNTLCIRGVQPL-------GSLLTLTIACVLALVGGFLAY--- 498

  Fly   526 LAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICR---------------QSILVVGEP------N 569
                ..::.::.:.::........|::.:..:.|               :|::..|.|      :
Mouse   499 ----FIRLGLQQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPRSVTQGS 559

  Fly   570 KRSF------TNIALFRGNIVAMKKIHK-KSVDITRSIRKELKLMREVRHENIINFIGASTDHGS 627
            .||.      ||:||::|..|.:||... .:.|:..|....|:.:||:||||:..|:|.....|.
Mouse   560 ARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMRHENVTAFLGLFVGPGV 624

  Fly   628 VIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRW 692
            ..:...:||||||||:|.||:|.||..|.:||:.|:::|:.|||... ..||.|:|.||::|:|:
Mouse   625 SAMVLEHCARGSLEDLLQNENLRLDWTFKASLLLDLIRGLRYLHHRR-FPHGRLKSRNCVVDTRF 688

  Fly   693 VCQISDFGLHELK----AGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYE 753
            |.:|:|.|..|..    :.:.:|...||     |..||||||.   ||:.:.||||:|..|:|.|
Mouse   689 VLKITDHGYAEFLESHCSSRPQPAPEEL-----LWTAPELLRG---PGKATFKGDVFSLAIILQE 745

  Fly   754 MIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDY-IRKC--LCQ-CWDEDPE 814
            ::.|..|:.....|.||||:.|..|..|    .||.::      ||. ..:|  |.| ||:|.|:
Mouse   746 VLTRDPPYCSWGLSAEEIIRKVASPPPL----CRPLVS------PDQGPLECIQLMQLCWEEAPD 800

  Fly   815 VRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLP 879
            .||.:..:....|.:..|.|.::.|:||.::|||:.:||.||||||..|..|::||:.||.||||
Mouse   801 DRPSLDQIYTQFKSINQGKKTSVVDSMLRMLEKYSESLEDLVQERTEELELERRKTERLLSQMLP 865

  Fly   880 RPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYK 944
            ..||..||.|..||.|.||.|||.||||||||.:...|.|.|||..|||.||..|:::.::||||
Mouse   866 PSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYK 930

  Fly   945 VETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGV 1009
            ||||||||||.||||.:||:|||.|||:|||.:|...||.::||.|...:::|.|:|||||.|||
Mouse   931 VETIGDAYMVASGLPRRNGNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGV 995

  Fly  1010 VGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQ-LLQVIGSYVCIERGLTSIKGKGDMRT 1073
            ||..|||||||||||||||||||||...|||:|::|.| ||.:...|....||.|.:||||...|
Mouse   996 VGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEET 1060

  Fly  1074 YWLTKRQ---QPELTP 1086
            ||||.:.   :|..||
Mouse  1061 YWLTGKVGFCRPLPTP 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	92/436 (21%)
		PK_GC-A_B	550..832	CDD:270944	106/317 (33%)
		CYCc	865..1057	CDD:214485	118/192 (61%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594	91/433 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	529..557		3/27 (11%)
		PK_GC-2D	554..818	CDD:270945	101/282 (36%)
		CYCc	855..1044	CDD:214485	117/188 (62%)
		Interaction with NCALD. /evidence=ECO:0000250|UniProtKB:P51839	874..915		24/40 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1096..1117