Protein Alignment Gyc32E and Gucy2c

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001120790.1
• Gene: Gucy2c / 14917
• MGIID: 106903
• Length: 1072
• Species: Mus musculus
• Alignment Length: 1077
• Identity: 328/1077 - (30%)
• Similarity: 499/1077 - (46%)
• Gaps: 212/1077 - (19%)

  Fly   100 LRAMTQMREAGVTAFIGPDESC---TTEALLASAWNTPMLS-----FKCSDPIVSNKSTFHTFAR 156
            ||.:|:..:.| .|.:||  ||   |.:..|.:..|.||:|     ..|...        .|..|
Mouse   106 LREITRDHKMG-CALMGP--SCTYSTFQMYLDTELNYPMISAGSYGLSCDYK--------ETLTR 159

  Fly   157 TLAPASKVSKSVISL-------LNAFHWNKFSIVVS-SKP---IWGSDVARAIQELAEARNFTIS 210
            .|.||.|:...::..       ...|.||...:..: |:|   .|..:...|          .:|
Mouse   160 ILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEA----------GVS 214

  Fly   211 HFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVD 275
            :|..:.::....:...|..:|:......:.:.|..|...:..|....||     .:.|.:|:.||
Mouse   215 YFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQ-----VAEDTVVILVD 274

  Fly   276 ---DEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYA 337
               :..::.|...    ..|:|                 :|:.:::...|:.....:..:..  :
Mouse   275 LFSNHYFEENTTA----PEYMD-----------------NVLVLTLPSEQSTSNTSVAERFS--S 316

  Fly   338 RKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSI 402
            .::.|.:.|.:...      ::| |:..:.                :.:|..|....|.|::.::
Mouse   317 GRSDFSLAYLEGTL------LFG-HMLQTF----------------LENGENVTGPKFARAFRNL 358

  Fly   403 --QGF--DVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYD--KNSVIPEFRY 461
              |||  .|.:|.:||.:...:::.:..|...       .|:.|:      ||  ||..||
Mouse   359 TFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRK-------YKVLMK------YDTHKNKTIP---- 406

  Fly   462 IKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALLI-KHYRYEQT 525
            :..:....|.|.:.|...|..|      |:..:...:.::|   .|||::.||||: :.||.:..
Mouse   407 VAENPNFIWKNHKLPNDVPGLG------PQILMIAVFTLTG---ILVVLLLIALLVLRKYRRDHA 462

  Fly   526 LAGLLWK-VDMKDVTVINLGEYN-------NPTNKNIFQICRQ----SILVVGEPNKRSFTNIAL 578
            |....|. :..:::..:...|.|       :...::..|..||    ...|:.:..|.|..|.:
Mouse   463 LRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHSDGNFS- 526

  Fly   579 FRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDV 643
                       .|:.:|:.:.::.:        :.|:..|.|.......:.....||.||||.:|
Mouse   527 -----------EKQKIDLNKLLQSD--------YYNLTKFYGTVKLDTRIFGVVEYCERGSLREV 572

  Fly   644 LAN-----EDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHE 703
            |.:     :...:|..|..|:::||.|||.|||.|:|..||.|:|:||::|||.|.:|:|||.:.
Mouse   573 LNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNS 637

  Fly   704 LKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYS- 767
            :           |..|:.|..|||.||.|    ..|||||||||.|:..|:|.||    :|.|:
Mouse   638 I-----------LPPKKDLWTAPEHLRQA----TISQKGDVYSFAIIAQEIILRK----ETFYTL 683

  Fly   768 -----KEEIIQFVKCPEMLQHGVFRPAL---THTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRM 824
                 .|:|.:.    |......|||.|   |....::..|:  .:..||:||||.|||.:.:..
Mouse   684 SCRDHNEKIFRV----ENSYGKPFRPDLFLETADEKELEVYL--LVKSCWEEDPEKRPDFKKIES 742

  Fly   825 HLKELQAGL-----KPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAE 884
            .|.:: .||     ..:..|.::..::.|:.|||.||:|||.|...|:.:.|.|.:.:|||.|.:
Mouse   743 TLAKI-FGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVK 806

  Fly   885 LLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIG 949
            .||....||.|.::.|||.||||||||.:|..|||.|||:||||.|...|.|:.::|||||||||
Mouse   807 SLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIG 871

  Fly   950 DAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKM 1014
            |||:|.||||::||:|||.:|:.:||.:|..:|..::.|.|...|.:|||||||||||||||.||
Mouse   872 DAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKM 936

  Fly  1015 PRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWLT- 1077
            ||||||||||||||||||||..:|||:|.:|..:|:........| ||.|.:||:|...|||||
Mouse   937 PRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDCQFLYEVRGETYLKGRGTETTYWLTG 1001

  Fly  1078 -KRQQPEL-TPDLISTVDTLDTYCSGPRESMEVSVHQ 1112
             |.|:..| :|..:.....|.|..|    .|.||..|
Mouse  1002 MKDQEYNLPSPPTVENQQRLQTEFS----DMIVSALQ 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	65/373 (17%)
		PK_GC-A_B	550..832	CDD:270944	91/299 (30%)
		CYCc	865..1057	CDD:214485	110/191 (58%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_type1	35..415	CDD:471960	71/397 (18%)
		Protein Kinases, catalytic domain	480..749	CDD:473864	93/314 (30%)
		CYCc	787..978	CDD:214485	110/190 (58%)