Protein Alignment Gyc32E and gucy2d

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_005165318.1
• Gene: gucy2d / 140426
• ZFINID: ZDB-GENE-011128-9
• Length: 1141
• Species: Danio rerio
• Alignment Length: 1109
• Identity: 365/1109 - (32%)
• Similarity: 543/1109 - (48%)
• Gaps: 184/1109 - (16%)

  Fly    64 LAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDES--CTTEAL 126
            ||:..:||:|.|..|....:..::.....|    :.|....::...| :||:||...  ||...|
Zfish   102 LAMSRINKDPELNKGYWYDYTVINEDCSSS----RGLARFAELEGYG-SAFLGPANPGYCTAATL 161

  Fly   127 LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIW- 190
            ||..||..:||:.|....: ::..:.||.|.|..:|:|   :.|:|..|.|....||.:...:|
Zfish   162 LAKNWNKGILSWGCLKAEM-DEEMYPTFLRPLPLSSRV---LFSVLRFFRWAHVGIVTAEGDMWE 222

  Fly   191 --GSDVARAIQELAEARNFTISHFKYISDYIPTTK--TLSQIDK-----IIEETYATTRIYVFI- 245
              |.::|.:::.|.                :|..|  |:.| ||     .::....|.|:.|.|
Zfish   223 ATGHELAASLRALG----------------LPVGKVVTMEQ-DKEGPRQALQAIRDTDRVRVVIM 270

  Fly   246 GEHIAMVDFVRGLQ------NRRLLESGDYIVVSVDDEIYD---SNRRVNIMERNYLDPYIRKEK 301
            ..|.|::......|      ..|:::.| ||.:..|..:|.   .|.:..|:..   |..:|:
Zfish   271 CMHSALIGGEEQYQLLTTALEMRMIDRG-YIFIPYDTLLYSLPYENVKYPILAN---DSKLRR-- 329

  Fly   302 SKSLDKISFRSVIKISMTY-PQNPH-----------IRDICSKIKDYARKTPFLVPYHQRVFDNI 354
                   ::..|:.::|.. .||.:           ||...|.    ...|.::.|:...:::
Zfish   330 -------AYDGVLTVTMDQGEQNFYEAFNAAQESFEIRGSTSA----EEVTRWVSPFFGTIYN-- 381

  Fly   355 SVPIYGLHLYDSVMIYVRAI-TEVLRL--GGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAE 416
                         |||..|: .|..|.  ||....|:|:..   |.......||:..|....:.|
Zfish   382 -------------MIYYTAMAAEQSRASSGGRWVSGDLLSQ---NEGGFEFDGFNQRISGGTNGE 430

  Fly   417 G---NYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLN------ 472
            |   .|.|  |.:| |||:|:               |..:::.....|.|.. .:::|.
Zfish   431 GMQVRYAV--LDSD-GSGSSL---------------YRTHALEASHTYGKYG-GLKYLGKSIHFA 476

  Fly   473 GRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALLIKHYR-------YEQTLAG-- 528
            |..|.::..|.|...:.....||...|....:..:|::....:|....|       :...:.|
Zfish   477 GASPSSDANCWFSPYIACSGGLDGVTLFFLLMFFIVLIAGAGILFLQVRKYGAGGFFGAFIGGGG 541

  Fly   529 ----LLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEP----NKRSF-------TNIAL 578
                ::..:|  |:..||........|.   :...:|.|.|..|    :.||:       :|:|:
Zfish   542 SPTKIVLTLD--DLVFINTTLSRRKLND---ESMLKSQLDVKTPRHSVSGRSYITSTPETSNVAV 601

  Fly   579 FRGNIVAMKK--IHKKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLE 641
            |.|:.|.:||  ......:|:.|.:.....:|::||||:..|:|...|.|...|.|.:|.|||||
Zfish   602 FEGDWVWLKKCPCADSITEISESTQTIFVKLRDMRHENLNLFLGLFMDTGIFGIVTEHCTRGSLE 666

  Fly   642 DVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKA 706
            |:|.||::.||.||.|||:.|:::||.|||:..|| ||.|:|.||::|.|:|.:::|:|.:|:..
Zfish   667 DLLNNEEMRLDWMFKSSLLLDLIRGMKYLHNRGII-HGRLKSRNCVVDGRFVLKVTDYGFNEILN 730

  Fly   707 GQE---EPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSK 768
            .|.   |.|..|.:    ...|||:||:.....:|:..||||||.|::.|:|.|..|:.......
Zfish   731 CQNIILEDNAPEDQ----FWTAPEILRNPDLKKKGTYPGDVYSFSIIMQEVISRCAPFCMLDMPP 791

  Fly   769 EEIIQFVKCPEMLQHGVFRP--ALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQA 831
            ||||:.|:.|..|    .||  ::....||:...::    |.|.|:||.||....:....|.:..
Zfish   792 EEIIEKVRSPPPL----CRPTVSMDEAPLDVIQLMK----QAWSEEPEQRPTFEDIFRQFKSMNK 848

  Fly   832 GLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAEC 896
            |.|.||.|:||.::|:|:.|||.|::|||..|..|::|||.||.||||:.||..||.|.||:.|.
Zfish   849 GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVERQKTDALLAQMLPKSVALALKTGKPVKPEH 913

  Fly   897 FDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQ 961
            |..||:.||||||||.:...|.|.|||::|||.||..|.||:.:||||||||||||||.||:|.:
Zfish   914 FAEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDVYKVETIGDAYMVASGVPNR 978

  Fly   962 NGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNT 1026
            ||:|||.|:|:::|.:|..:|..|:||.|...|::|||:||||..|||||.||||||||||||||
Zfish   979 NGTRHAAEMANMSLDILHCIGTFKMRHMPDVKVKIRIGLHSGPVVAGVVGLKMPRYCLFGDTVNT 1043

  Fly  1027 ASRMESTGDSMRIHISEATYQLLQVIG-SYVCIERGLTSIKGKGDMRTYWLTKRQ--------QP 1082
            ||||||||...|||::::|..:|..:. .|....||.|.:||||...|:||..|.        .|
Zfish  1044 ASRMESTGLPYRIHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVEETFWLVGRDGFDKPLPIPP 1108

  Fly  1083 ELTP 1086
            :|||
Zfish  1109 DLTP 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	96/423 (23%)
		ANF_receptor	59..427	CDD:279440	91/402 (23%)
		PHA02988	534..826	CDD:165291	107/309 (35%)
		PK_GC-A_B	550..832	CDD:270944	104/299 (35%)
		HNOBA	<847..886	CDD:285003	21/38 (55%)
		CYCc	865..1057	CDD:214485	114/192 (59%)
		Guanylate_cyc	892..1076	CDD:278633	106/184 (58%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366	99/447 (22%)
		PK_GC-2D	581..849	CDD:270945	99/280 (35%)
		HNOBA	<858..903	CDD:311573	24/44 (55%)
		CYCc	883..1075	CDD:214485	114/191 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920