Protein Alignment Gyc32E and gucy2f

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_571939.2
• Gene: gucy2f / 140424
• ZFINID: ZDB-GENE-011128-7
• Length: 1107
• Species: Danio rerio
• Alignment Length: 1092
• Identity: 363/1092 - (33%)
• Similarity: 557/1092 - (51%)
• Gaps: 164/1092 - (15%)

  Fly    64 LAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDES--CTTEAL 126
            ||:..:|.:.:|..|..:.|..:....:.|    |.|.:..|. |....||:||...  |...||
Zfish    83 LAVGRINNDFSLDLGCTMDFVILQEACETS----KALTSFVQY-ENVADAFVGPTNPGYCNAAAL 142

  Fly   127 LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWG 191
            ::..|:..:.|:.|.:..:.....:.||||||....:|   :.::|..|.|....||.|::.||.
Zfish   143 MSKNWDKSLFSWACVNHELDRVQGYPTFARTLPSPLRV---LFNVLKFFRWANIGIVSSNEDIWI 204

  Fly   192 SDVARAIQELAEA-RNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTR----IYVFIGEHIAM 251
            ...|:    ||.| ||..:.        :....::...|.::|.|..:.:    |.|.|   :.|
Zfish   205 DTAAK----LASALRNRGLP--------VGIVTSMGNNDTMLENTLMSIKNAGDIKVII---MCM 254

  Fly   252 VDFVRGLQNRRL---------LESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDK 307
            ...:.|.:.:..         |.||.|:.:..|..:| |...:||       .|...:.:..|.|
Zfish   255 HSVLIGGEQQATFLTKAYDMGLASGRYVFIPYDTLLY-SLPYINI-------TYYPLQNNSKLSK 311

  Fly   308 ISFRSVIKIS-----MTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSV 367
             ::.:|:.|:     ||:          ::..:.|::...|:...:.  :.:| |::|. :|:|:
Zfish   312 -AYDAVLTITLDSDIMTF----------NEAFNAAKQLGELMVTQEP--EQVS-PLFGT-IYNSL 361

  Fly   368 MIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGF--DVYIDSNGDAEGNYTVITLQNDVGS 430
            .:..:::....|.|..:...||.   .|.|:. :..||  |:..|..|:.:.||.::..:
Zfish   362 YLLAKSMHNARRAGRWLSGTNLA---YFTRNI-TFTGFNQDIQTDEQGNGQTNYVILDTE----- 417

  Fly   431 GASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLD 495
                    ....|....|..|..|.:..|.    .|.|.:....||.::..|.|.........:|
Zfish   418 --------AWGTQLYRCFLVDMTSDLVLFA----GRFIHFPGESPPPSDSRCWFEDNAICTGGVD 470

  Fly   496 WRYLVSGPLCALVVV---VAIALLI-KHYRYEQTLAG---LLWKVDMKDVTVINLGEYNNPTNKN 553
            ..|::...:..|::|   :.::|.| :..:..|.:.|   :|  :.::|:|.|      ||
Zfish   471 IIYVIIAFVIVLIIVLGSIGLSLFIRRRIQQIQLIKGPNRIL--LTLEDLTFI------NP---- 523

  Fly   554 IFQICRQSILVVGEPNKRSF-----------------------TNIALFRGNIVAMKKI---HKK 592
              |:.::.|.:....:.:|:                       :|:|::.|:.|.:||.   |.|
Zfish   524 --QLSKRKITLEDLSDSKSYIEEKSTGDRSRSVNSMATATHETSNVAVYEGDWVWLKKFTEGHFK 586

  Fly   593 SVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFIS 657
              ::.:|..|....|:::|:||:..|:|..||.....|.|.:|:||||.|:|.|:|:.||.||.|
Zfish   587 --EVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRNDDVKLDWMFKS 649

  Fly   658 SLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRAL 722
            |||.|::|||.|||..| ..||.|:|.||::|.|:|.:|:|:|.:|:...|:.| |..|..:...
Zfish   650 SLVLDLIKGMKYLHHRE-FPHGRLKSRNCVVDGRFVLKITDYGYNEILETQKAP-KETLPPEDLF 712

  Fly   723 CMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFR 787
            ..|||.|||...|.:|:.|||||||.|:|.|::.|..|:.....|.||||:.||.|..:    .|
Zfish   713 WTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEEIIRKVKKPPPM----CR 773

  Fly   788 PALTHTHLDIPDYI-RKC---LCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKY 848
            |.:.      ||.. .:|   :.|||.|.|:.||....:....|.:..|.|.||.|:||.::|:|
Zfish   774 PTVA------PDQAPLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTNIIDSMLRMLEQY 832

  Fly   849 AYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTEL 913
            :.|||.|::|||..|..||::|:.||.:|||..|||.||.|..||.|.||.|||.||||||||.:
Zfish   833 SSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVTIYFSDIVGFTTI 897

  Fly   914 CTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLL 978
            .:.|.|.|||::|||.|:..|:::.::||||||||||||||.||||.:||::||.|||:::|::|
Zfish   898 SSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANMSLNIL 962

  Fly   979 ETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISE 1043
            .:||:.|:||.|...|::|||:|||||.|||||..|||||||||||||||||||||...|||::.
Zfish   963 SSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNI 1027

  Fly  1044 ATYQLLQVIG-SYVCIERGLTSIKGKGDMRTYWLTKR--------QQPELTP 1086
            :|.|:|:.:. .|....||.|.:||||...||||..:        ..||:.|
Zfish  1028 STVQILRSLNDGYKIDVRGKTELKGKGIEETYWLVGKANFTKPLPNPPEIKP 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	87/406 (21%)
		PK_GC-A_B	550..832	CDD:270944	106/311 (34%)
		CYCc	865..1057	CDD:214485	115/192 (60%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF-like	59..440	CDD:380594	91/423 (22%)
		PK_GC-2D	551..816	CDD:270945	103/278 (37%)
		HNOBA	<825..870	CDD:462234	23/44 (52%)
		CYCc	850..1042	CDD:214485	115/191 (60%)