DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and LRRK2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	1077	Identity:	205/1077 - (19%)
Similarity:	376/1077 - (34%)	Gaps:	369/1077 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CASAAAFSCILVLLLLGCQRSNPLAAGATVSSMRRLTDTINIGFLAE--YSQMRVTLGGLP-LAI 66
            |....:||.          |.|.|||      |..|..::.|..|::  :|.:...:..|| |..
Human  1152 CPKVESFSA----------RMNFLAA------MPFLPPSMTILKLSQNKFSCIPEAILNLPHLRS 1200

  Fly    67 EDVNKNP-NLLPG----KKLAFKPVDIGHKM--------SAY---RVKPLR-AMTQMREAGVTAF 114
            .|::.|. ..|||    |.|..:.:...|..        .||   ||:.|. :..:::|
Human  1201 LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKE------ 1259

  Fly   115 IGPDESCTTE-------------------ALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAP 160
            |.|:..|...                   ..|:..|:.|:      |.:..|....|...:
Human  1260 IPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPL------DELHLNFDFKHIGCK---- 1314

  Fly   161 ASKVSKSVISLL-----NAFHWNKFSIVVSSKPIWGSDVARAIQELAEARNFTISHFKY-----I 215
                :|.:|..|     .|..:|:..:::....  ||.....:|:|.:.:...:.....     :
Human  1315 ----AKDIIRFLQQRLKKAVPYNRMKLMIVGNT--GSGKTTLLQQLMKTKKSDLGMQSATVGIDV 1373

  Fly   216 SDYIPTTKTLSQIDKII--------EETYAT-------TRIYVFI-------GEHIAMVDFVRGL 258
            .|:....:...:.|.::        ||.|:|       ..:|:.:       .|..||..::..:
Human  1374 KDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNI 1438

  Fly   259 QNRRLLESGDYIVVSVDDEIYDSNRRVNIM---------ERNYLDPYIR-------KEKSKSLDK 307
            :.|  ..|...|:|....::.|..:|...|         :|.:  |.||       .|:|.:|.|
Human  1439 KAR--ASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGF--PAIRDYHFVNATEESDALAK 1499

  Fly   308 ISFRSVIKISMTYPQNPHIRD------------------ICSKIKDYARKTPF--------LVPY 346
            :. :::|..|:.:    .|||                  |.|:.|:...:.|.        ||..
Human  1500 LR-KTIINESLNF----KIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRE 1559

  Fly   347 HQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGN-----LVMSHI------------ 394
            :|...|...:| :.:|..:...:.:......|:| .|:|...     .:|:.|
Human  1560 NQLQLDENELP-HAVHFLNESGVLLHFQDPALQL-SDLYFVEPKWLCKIMAQILTVKVEGCPKHP 1622

  Fly   395 ------------------FNRSYHS-----IQGFDV-------YIDSNGDAEGNYTVITLQNDVG 429
                              |.::|.|     ::.|.:       |:........:..||.|.:...
Human  1623 KGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCEN 1687

  Fly   430 SGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRP-------IQW-----LNGRPPLAEPLC 482
            |...| .|.:|...|:||::...|.::....|:.:.|.       :.|     ||..|   |..|
Human  1688 SEIII-RLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSP---EAYC 1748

  Fly   483 GFHGELC---PRKKLDWRYLVSGPLCALVVVVAIALLIKHY--RYEQTLAGLLWKVDM--KDVTV 540
            ....|:.   |...|.    ::.|.|....:: :..::.|.  ..|:...||| ::|:  :..|:
Human  1749 LVGSEVLDNHPESFLK----ITVPSCRKGCIL-LGQVVDHIDSLMEEWFPGLL-EIDICGEGETL 1807

  Fly   541 I--------NLGEYN-------------------NPTNKN----IFQICRQSIL----------- 563
            :        |.||.:                   ||....    |.||....||
Human  1808 LKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNN 1872

  Fly   564 -----------VVGEPNKRSFTNI--ALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENI 615
                       ::|:   .||.::  |.:.|..||:|..:|.:  ..|.:|:||.::..:.|.::
Human  1873 DELEFEQAPEFLLGD---GSFGSVYRAAYEGEEVAVKIFNKHT--SLRLLRQELVVLCHLHHPSL 1932

  Fly   616 INFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGN 680
            |:.:.|......:::  ...::|||:.:|..:...|.......:...:..|:.|||.:.|| :.:
Human  1933 ISLLAAGIRPRMLVM--ELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMII-YRD 1994

  Fly   681 LRSSNCLI-----DSRWVCQISDFGLHE------LKAGQEEPNKSELELKRALCMAPELLRDAYR 734
            |:..|.|:     ::..:.:|:|:|:.:      :|..:..|.          ..|||:
Human  1995 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPG----------FRAPEV------ 2043

  Fly   735 PGRG----SQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCP----EMLQHGVFRPALT 791
             .||    :|:.||||||:|||:::...|          .|::.:|.|    |:...|
Human  2044 -ARGNVIYNQQADVYSFGLLLYDILTTGG----------RIVEGLKFPNEFDELEIQG------- 2090

  Fly   792 HTHLDIPDYIRKCLC-----------QCWDEDPEVRP 817
                .:||.:::..|           ||..|:|:.||
Human  2091 ----KLPDPVKEYGCAPWPMVEKLIKQCLKENPQERP 2123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	98/563 (17%)
		ANF_receptor	59..427	CDD:279440	89/525 (17%)
		PHA02988	534..826	CDD:165291	77/371 (21%)
		PK_GC-A_B	550..832	CDD:270944	70/326 (21%)
		HNOBA	<847..886	CDD:285003
		CYCc	865..1057	CDD:214485
		Guanylate_cyc	892..1076	CDD:278633
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223	33/155 (21%)
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380	10/37 (27%)
		LRR 8	1174..1196		3/21 (14%)
		leucine-rich repeat	1175..1197	CDD:275380	4/21 (19%)
		LRR 9	1197..1218		6/20 (30%)
		leucine-rich repeat	1198..1221	CDD:275380	7/22 (32%)
		LRR 10	1221..1241		1/19 (5%)
		leucine-rich repeat	1222..1246	CDD:275380	3/23 (13%)
		LRR 11	1246..1267		6/26 (23%)
		leucine-rich repeat	1247..1269	CDD:275380	6/27 (22%)
		LRR 12	1269..1291		0/21 (0%)
		RocCOR	1334..1507	CDD:206741	30/179 (17%)
		COR	1527..1740	CDD:318343	35/215 (16%)
		STKc_LRRK2	1884..2135	CDD:270970	65/286 (23%)
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900