Protein Alignment Gyc32E and Gucy2f

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_446283.1
• Gene: Gucy2f / 116556
• RGDID: 620439
• Length: 1108
• Species: Rattus norvegicus
• Alignment Length: 1102
• Identity: 363/1102 - (32%)
• Similarity: 546/1102 - (49%)
• Gaps: 200/1102 - (18%)

  Fly    64 LAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQM--REAGVTAFIGPDES--CTTE 124
            ||||.::::.:.  .:..:|:.|.:...     .:..:|:|..  .:...:.|:||...  |...
  Rat    78 LAIERISRDMSF--DRSYSFEYVILNED-----CQTSKALTSFISHQQMASGFVGPANPGYCEAA 135

  Fly   125 ALLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPI 189
            :||.::|:..:.|:.|.:..:.||.::.||:|||....:|   :::::..|.|....::.|.:.|
  Rat   136 SLLGNSWDKGIFSWACVNHELDNKHSYPTFSRTLPSPIRV---LVTVMKYFQWAHAGVISSDEDI 197

  Fly   190 W---GSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFI-GEHIA 250
            |   .:.|:.|::          ||...:...:.:.:....|.|.:::.....||.:.| ..|.|
  Rat   198 WVHTANQVSSALR----------SHGLPVGVVLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSA 252

  Fly   251 MVDFVRGLQNRRLLE--------SGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDK 307
            ::.   |......||        .|.|:.|                      ||
  Rat   253 LIG---GETQTHFLELAHDLKMTDGTYVFV----------------------PY----------- 281

  Fly   308 ISFRSVIKISMTYPQNPH--IRDICSKIKDYARKTPFLVPYHQRVF-----------------DN 353
                .|:..|:.|..:|:  :|:.....:.|.......|..|::.|                 |:
  Rat   282 ----DVLLYSLPYKHSPYQVLRNNQKLREAYDAVLTITVESHEKTFYEAFTEAAAGGEIPEKLDS 342

  Fly   354 ISV-PIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYI--DSNGDA 415
            ..| |::|. :|:|:....:|::..|:..|.....:|. .|..|..::   ||:..|  ||||:.
  Rat   343 HQVSPLFGT-IYNSIYFIAQAMSNALKENGQASAASLT-RHSRNMQFY---GFNQLIRTDSNGNG 402

  Fly   416 EGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEP 480
            ...|.::....             ...:..|.:..|..:.:..||    ..||.:..|||..|:.
  Rat   403 ISEYVILDTNG-------------KEWELRGTYTVDMETELLRFR----GTPIHFPGGRPTSADA 450

  Fly   481 LCGF-HGELCPRKKLDWRYLVSGPLCALVVVVAIALL-----IKHYRY--------EQTLAG--- 528
            .|.| .|::|.          .|...||.::|..|||     |..:.|        .|.:.|
  Rat   451 KCWFAQGKICQ----------GGIDPALAMMVCFALLLALLSINGFAYFIRRRINKIQLIKGPNR 505

  Fly   529 LLWKVDMKDVTVIN--LGEYNNPTNKNIFQICRQSILVVGEPNKRSF------------TNIALF 579
            :|  :.::|||.||  .|..........|||.  |.:..|...:.||            :|||::
  Rat   506 IL--LTLEDVTFINPHFGSKRGSRASVSFQII--SEVQSGRSPRLSFSSGSLTPATYENSNIAIY 566

  Fly   580 RGNIVAMKKIHKKSVDITRSIRKE----LKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSL 640
            :|:.|.:||.........:||:..    .::|:::||||:...:|...|.|...|.:.:|:|.||
  Rat   567 QGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSL 631

  Fly   641 EDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFG----L 701
            ||:|..:|:.||.||.|||:.|::|||.|||..|.| ||.|:|.||::|.|:|.:::|:|    |
  Rat   632 EDILTQDDVKLDWMFKSSLLLDLIKGMKYLHHREFI-HGRLKSRNCVVDGRFVLKVTDYGFNNIL 695

  Fly   702 HELKAGQEEPNKSELELKRALCMAPELLRDAYRPG---RGSQKGDVYSFGILLYEMIGRKGPWGD 763
            ..|:..:|||::.||     |..||||||   .||   .||..||||||.|::.|::.|..|:..
  Rat   696 EMLRLSEEEPSEEEL-----LWTAPELLR---APGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCM 752

  Fly   764 TAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYI-RKCL---CQCWDEDPEVRPDIRLVRM 824
            ...|.:|:|..:|.|.    .|:||.::      |::. .:||   .|||.|..|.||....:..
  Rat   753 MDLSAKEVIDRLKMPP----PVYRPVVS------PEFAPPECLQLMKQCWAEAAEQRPTFDEIFN 807

  Fly   825 HLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRG 889
            ..|....|.|.||.|:||.::|:|:.|||.|::|||..|..||:||:.||.||||..|||.||:|
  Rat   808 QFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKG 872

  Fly   890 DPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMV 954
            ..||.|.||.||:.||||||||.:...|.|.|||::|||.||..|:||.::||||||||||||||
  Rat   873 CTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMV 937

  Fly   955 VSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCL 1019
            .||||.:||||||.|||:::|.:|.:||..|:||.|...|::|||:|:||..|||||..||||||
  Rat   938 ASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHTGPVVAGVVGLTMPRYCL 1002

  Fly  1020 FGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWLTKRQ 1080
            |||||||||||||||...|||:|.:|..:|:.:.....:| ||.|.:||||...|:||..::
  Rat  1003 FGDTVNTASRMESTGLPYRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVGKK 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	79/421 (19%)
		PK_GC-A_B	550..832	CDD:270944	107/308 (35%)
		CYCc	865..1057	CDD:214485	118/191 (62%)
Gucy2f	NP_446283.1	PBP1_sensory_GC_DEF-like	54..435	CDD:380594	82/438 (19%)
		Protein Kinases, catalytic domain	545..815	CDD:473864	102/288 (35%)
		HNOBA	<824..869	CDD:462234	25/44 (57%)
		CYCc	848..1040	CDD:214485	118/191 (62%)