Protein Alignment Gyc32E and Adcy7

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_006530643.1
• Gene: Adcy7 / 11513
• MGIID: 102891
• Length: 1146
• Species: Mus musculus
• Alignment Length: 1194
• Identity: 240/1194 - (20%)
• Similarity: 410/1194 - (34%)
• Gaps: 435/1194 - (36%)

  Fly   128 ASAW-NTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAF-HWNKFSIVVSSKPIW 190
            |.|| ..|...|          ..|..:|  |.|.|:.:..|..:.:.. |...|..|..:....
Mouse   120 AHAWEQVPFFLF----------VVFVVYA--LLPLSRRAAIVAGVTSTVSHLLVFGAVTRAFQTS 172

  Fly   191 GSDVARAIQELAEA-----RNFTISHFKY-ISD-----YIPTTKTLS-----QIDKIIEETYATT 239
            .|.....:|.||.|     .|||.:..|: :.|     :|.|.|.:.     :::|..:|....:
Mouse   173 MSSTQLGLQLLANAVILLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLS 237

  Fly   240 RI--YVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKS 302
            .:  ::.:|..:|:::        ||.|.||               |..:.:.|:...|:::.::
Mouse   238 VLPAHISMGMKLAIIE--------RLKEGGD---------------RHYMPDNNFHSLYVKRHQN 279

  Fly   303 KSL---DKISF----------RSVIKISMTYPQNPHI--RDICSKIKDY------ARKTPFLVPY 346
            .|:   |.:.|          ..|:.::..:.:...|  .:.|.:||..      ....|..:|.
Mouse   280 VSILYADIVGFTRLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPT 344

  Fly   347 HQRVFDNISVPIYGLHLYDSVMIYVRAITEV---LRLGGDIYDGNLVMSHIFNRSY-HSIQGFDV 407
            |.|     :....||.:.:::. .||..|.|   :|:|  |:.||::...|..|.: :.:...||
Mouse   345 HAR-----NCVKMGLDICEAIK-QVREATGVDISMRVG--IHSGNVLCGVIGLRKWQYDVWSHDV 401

  Fly   408 YIDSNGDAEG-----NYTVITLQN-------DVGSGASIGS-LAKMSM----------------- 442
            .:.:..:|.|     :.|..||.:       :.|.|..... |.:|::
Mouse   402 SLANRMEAAGVPGRVHITEATLNHLDKAYEVEDGHGEQRDPYLKEMNIRTYLVIDPRSQQPPPPS 466

  Fly   443 ----QPVGFFAYDKNSVIPEFRYIKN---DRPIQWLNGRP------------------PL----- 477
                :|.|.......:.:...||:::   .||...||.|.                  ||
Mouse   467 HHLSKPKGDATLKMRASVRVTRYLESWGAARPFAHLNHRESVSSSETPISNGRRQKAIPLRRHRA 531

  Fly   478 ----------------------------AEPLCG----FH--GELCPRKKLDWRY-LVSGP---- 503
                                        ..|.|.    ||  |.:...|..:..| ||..|
Mouse   532 PDRSASPKGRLEDDCDDEMLSAIEGLSSTRPCCSKSDDFHTFGPIFLEKGFEREYRLVPIPRARY 596

  Fly   504 --LCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVG 566
              .||.:|.|.|.|:                                    ::..:.|.:.|.|
Mouse   597 DFACASLVFVCILLV------------------------------------HLLVMPRMATLGV- 624

  Fly   567 EPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSI--RKELKLMRE-VRHENIINFIGASTDHGSV 628
                 ||..:|...|.:::.    ..:.:.:|..  |..|:.:.| |..:.::..:        :
Mouse   625 -----SFGLVACLLGLVLSF----CFATEFSRCFPSRSTLQAISESVETQPLVRLV--------L 672

  Fly   629 IIFTTYCARGSLEDV-LANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRW 692
            ::.|.    |||..| :.|..|
Mouse   673 VVLTV----GSLLTVAIINMPL------------------------------------------- 690

  Fly   693 VCQISDFGLHELKAGQEEP--NK-SELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEM 754
                      .|..|.|:|  || |.|..:..:....|||
Mouse   691 ----------TLNPGPEQPGDNKTSPLAAQNRVGTPCELL------------------------- 720

  Fly   755 IGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCW---DEDPEVR 816
                 |:    |:...|:.|:.|...|:..:...|:..|...:...:...|..||   ....|..
Mouse   721 -----PY----YTCSCILGFIACSVFLRMSLELKAMLLTVALVAYLLLFNLSPCWHVSGNSTETN 776

  Fly   817 PDIRLVRMHLKELQA--------GLK-----PNIFDNMLSIMEK------------------YAY 850
            ...| .|:.|.:.|:        |.:     |:..:..|.||..                  |..
Mouse   777 GTQR-TRLLLSDAQSMPSHTLAPGARETAPSPSYLERDLKIMVNFYLILFYATLILLSRQIDYYC 840

  Fly   851 NLEGLVQERTNLLYEEKKKTD----MLLYQMLPRPVAELL---KRGDPVEAECFDCVTILFSDI- 907
            .|:.|.:::....:||.:..:    :||..:||..||...   |..:....:.:|||.::|:.:
Mouse   841 RLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFASVP 905

  Fly   908 ---VGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYD----------VYKVETIGDAYMVVSGLP 959
               |.:||........|.:.:||:       ||:::|          |.|::|||..||..:||.
Mouse   906 DFKVFYTECDVNKEGLECLRLLNE-------IIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLS 963

  Fly   960 LQNGSR---------HAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMP 1015
            ..:|..         |.|.:...::.|:..:..:. ||. ..:.:||:|::.||..|||:|.:.|
Mouse   964 APSGHENQDLERKHVHIGVLVEFSMALMSKLDGIN-RHS-FNSFRLRVGINHGPVIAGVIGARKP 1026

  Fly  1016 RYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYW----- 1075
            :|.::|:|||.||||||||:..:|.::|.|..:||.:| |.|..|||.::||||::|||:
Mouse  1027 QYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLG-YSCECRGLINVKGKGELRTYFELFFL 1090

  Fly  1076 ------------LTKRQQPELTPD 1087
                        |.:|  |.||.|
Mouse  1091 NPSVGQGFVSGSLLRR--PSLTTD 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	77/398 (19%)
		PK_GC-A_B	550..832	CDD:270944	46/299 (15%)
		CYCc	865..1057	CDD:214485	67/221 (30%)
Adcy7	XP_006530643.1	AcyC	48..456	CDD:441717	75/378 (20%)
		Guanylate_cyc	272..422	CDD:425528	31/157 (20%)
		Adcy_cons_dom	487..594	CDD:461877	19/106 (18%)
		Guanylate_cyc	890..1085	CDD:425528	68/204 (33%)