DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and Adcy6

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_006520366.3	Gene:	Adcy6 / 11512	MGIID:	87917	Length:	1254	Species:	Mus musculus

Alignment Length:	648	Identity:	156/648 - (24%)
Similarity:	243/648 - (37%)	Gaps:	211/648 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 KKLDWRYLVSGP--LCALVV---VVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTN 551
            :|:|.|:   |.  .|||:|   :..|.||:..|                  :.:.||.|
Mouse   749 RKVDPRF---GAYVACALLVFCFICFIQLLVFPY------------------STLILGIY----- 787

  Fly   552 KNIFQICRQSILVVGEPNKRSFTNIALFR--GNIVAMKKIHKKSVDITRSIRKELKLMREVRHEN 614
            ..||.:...::|:....:..||...||.|  .||| ..::|..:|.|               ...
Mouse   788 AAIFLLLLVTVLICAVCSCGSFFPKALQRLSRNIV-RSRVHSTAVGI---------------FSV 836

  Fly   615 IINFIGASTDHGSVIIFT------TYCARGSLE----DVLA------NEDLHLD----------- 652
            ::.||.|..:     :||      ..||...|.    ||.|      |..|.||
Mouse   837 LLVFISAIAN-----MFTCNHTPIRTCAARMLNLTPADVTACHLQQLNYSLGLDAPLCEGTAPTC 896

  Fly   653 ---HMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKS 714
               ..|:.:::..:|...::||.|.|   |.|..:..|                          .
Mouse   897 SFPEYFVGNVLLSLLASSVFLHISSI---GKLAMTFIL--------------------------G 932

  Fly   715 ELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPE 779
            ...|...|...|..:.|.|         |:         ::|..|     ..|..|....:.||
Mouse   933 FTYLVLLLLGPPAAIFDNY---------DL---------LLGVHG-----LASSNETFDGLDCP- 973

  Fly   780 MLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLV-----RMHLKELQAGLKPNIFD 839
                .|.|.||.:                      :.|.|.||     .:|.:::::..:.:...
Mouse   974 ----AVGRVALKY----------------------MTPVILLVFALALYLHAQQVESTARLDFLW 1012

  Fly   840 NMLSIMEK------YAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELL----KRGDPVEA 894
            .:.:..||      .|||..                   ||:.:||:.||...    :|.|.:..
Mouse  1013 KLQATGEKEEMEELQAYNRR-------------------LLHNILPKDVAAHFLARERRNDELYY 1058

  Fly   895 ECFDCVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSIISN---YDVYKVETIGDAY 952
            :..:||.::|:.|..|:    ||...:...|.:.:||:.....|.|||.   ..:.|::|||..|
Mouse  1059 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTY 1123

  Fly   953 MVVSGLPL----QNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQK 1013
            |..|||..    |.|..|...:|..|:.|:|.:.:  |........|::||::.||..|||:|.:
Mouse  1124 MAASGLNASTYDQVGRSHITALADYAMRLMEQMKH--INEHSFNNFQMKIGLNMGPVVAGVIGAR 1186

  Fly  1014 MPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076
            .|:|.::|:|||.:|||:|||...||.::...||:|...| |....||:..:||||:|.||:|
Mouse  1187 KPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGEMTTYFL 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	61/328 (19%)
		PK_GC-A_B	550..832	CDD:270944	59/318 (19%)
		HNOBA	<847..886	CDD:285003	10/44 (23%)
		CYCc	865..1057	CDD:214485	67/206 (33%)
		Guanylate_cyc	892..1076	CDD:278633	68/194 (35%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454
		Guanylate_cyc	456..640	CDD:306677
		DUF1053	668..754	CDD:368844	2/4 (50%)
		Guanylate_cyc	1056..1250	CDD:306677	69/196 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810