DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc32E and ADCY8

DIOPT Version :9

Sequence 1:NP_001097148.1 Gene:Gyc32E / 34553 FlyBaseID:FBgn0010197 Length:1191 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:341 Identity:99/341 - (29%)
Similarity:160/341 - (46%) Gaps:44/341 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   847 KYAYNLEGL----VQERTNLLYEEKKKTDMLLYQMLPRPVAE--LLKRGDPVE--AECFDCVTIL 903
            :|...|:.|    .:|..|.:.|.::..:.:|..:||..||.  |.|..|..|  ::.:|.|.::
Human   920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVM 984

  Fly   904 FSDIVGFTELCTTSTPFEVVEMLNDWYTC---CDSIISNY----------DVYKVETIGDAYMVV 955
            |:.|.||.:.      :...||.|....|   .:.||:::          |:.|::|||..||.|
Human   985 FASIPGFADF------YSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAV 1043

  Fly   956 SGL-----PLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMP 1015
            |||     ..::...|...:|..:|.|.|::..:. :|. ....:||||:..|...|||:|.|.|
Human  1044 SGLSPEKQQCEDKWGHLCALADFSLALTESIQEIN-KHS-FNNFELRIGISHGSVVAGVIGAKKP 1106

  Fly  1016 RYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKG----KGDMRTYWL 1076
            :|.::|.|||.||||:|||.|.||.:.|.||.:|:..| :....||...:||    :|.::||:|
Human  1107 QYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQG-FAFDYRGEIYVKGISEQEGKIKTYFL 1170

  Fly  1077 TKRQQPE---LTPDLISTVDTLDTYCSGPRESMEVSVHQYCSPASNNYRLGSCNCDTKCLYSRRS 1138
            ..|.||.   |.|..:....:|.....|..:|:.....:.....:||..:...:.:.:.|.|...
Human  1171 LGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSG 1235

  Fly  1139 DDNVTNSHGT--SEFP 1152
            .:....:.||  |:.|
Human  1236 TEPGAQAEGTDKSDLP 1251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc32ENP_001097148.1 PBP1_Speract_GC_like 44..448 CDD:107365
ANF_receptor 59..427 CDD:279440
PHA02988 534..826 CDD:165291
PK_GC-A_B 550..832 CDD:270944
HNOBA <847..886 CDD:285003 11/44 (25%)
CYCc 865..1057 CDD:214485 70/213 (33%)
Guanylate_cyc 892..1076 CDD:278633 68/207 (33%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831
CYCc 366..564 CDD:214485
Guanylate_cyc 405..589 CDD:278633
DUF1053 617..711 CDD:283888
CYCc 944..1148 CDD:214485 69/212 (33%)
Guanylate_cyc 973..1172 CDD:278633 68/207 (33%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 42/142 (30%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215 1/14 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251 5/27 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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