Protein Alignment Gyc32E and ADCY7

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_011521137.1
• Gene: ADCY7 / 113
• HGNCID: 238
• Length: 1086
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 215/1076 - (19%)
• Similarity: 388/1076 - (36%)
• Gaps: 362/1076 - (33%)

  Fly   170 SLLNAFHWNKFSIVVSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEE 234
            :|..|||.::.           .|.:|.:             |.|....|...:.| :|:|..:|
Human   191 NLTGAFHKHQM-----------QDASRDL-------------FTYTVKCIQIRRKL-RIEKRQQE 230

  Fly   235 TYATTRI--YVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYI 297
            ....:.:  ::.:|..:|:::        ||.|.||              ||. :.:.|:...|:
Human   231 NLLLSVLPAHISMGMKLAIIE--------RLKEHGD--------------RRC-MPDNNFHSLYV 272

  Fly   298 RKEKSKSL---DKISFRS----------VIKISMTYPQNPHI--RDICSKIKDY------ARKTP 341
            ::.::.|:   |.:.|..          |:.::..:.:...|  .:.|.:||..      ....|
Human   273 KRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLP 337

  Fly   342 FLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEV---LRLGGDIYDGNLVMSHIFNRSY-HSI 402
            ..:|.|.|     :....||.:..::. .||..|.|   :|:|  |:.||::...|..|.: :.:
Human   338 VSLPTHAR-----NCVKMGLDMCQAIK-QVREATGVDINMRVG--IHSGNVLCGVIGLRKWQYDV 394

  Fly   403 QGFDVYIDSNGDAEG-----NYTVITLQN-------DVGSGASIGS-LAKMSMQPVGFFAYDKNS 454
            ...||.:.:..:|.|     :.|..||::       :.|.|..... |.:|:::.  :...|..|
Human   395 WSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRT--YLVIDPRS 457

  Fly   455 VIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLD-----------WRYLVSGPLCALV 508
            ..|                 ||.::.|        ||.|.|           .|||.|.
Human   458 QQP-----------------PPPSQHL--------PRPKGDAALKMRASVRMTRYLESW------ 491

  Fly   509 VVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTN---KNIFQICR----QSILVVG 566
               ..|....|..:.::               ::.||.:.|..   |::.|..|    :|:...|
Human   492 ---GAARPFAHLNHRES---------------VSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKG 538

  Fly   567 EPNKRSFTN--IALFRGNIVAMKKIHKKSVD--------ITRSIRKELKL--MREVRHE----NI 615
            .....|:.:  ::...| :.:.:....||.|        :.:...:|.:|  :...||:    ::
Human   539 RSEDDSYDDEMLSAIEG-LSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASL 602

  Fly   616 INFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGN 680
            | |:.....|  |::.....|.|....::|             .|..::.|:.:.
Human   603 I-FVCILLVH--VLLMPRTAALGVSFGLVA-------------CVLGLVLGLCFA---------- 641

  Fly   681 LRSSNCLIDSRWVCQISD--------------------------------FGLHELKAGQEEPNK 713
            .:.|.|......:|.||:                                |.:.||..|.|....
Human   642 TKFSRCCPARGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELPVGNETGLL 706

  Fly   714 SELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCP 778
            :.....||||   |.|                              |:    |:...::.|:.|.
Human   707 AASSKTRALC---EPL------------------------------PY----YTCSCVLGFIACS 734

  Fly   779 EMLQHGVFRPALTHTHLDIPDYIRKCLCQCWD--------------------------EDPEVRP 817
            ..|:..:....:..|...:...:...|..||.                          :|.:...
Human   735 VFLRMSLEPKVVLLTVALVAYLVLFNLSPCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMT 799

  Fly   818 DIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTD----MLLYQML 878
            :..||..::..|           .||....|...|:.|.:::....:||.:..:    :||..:|
Human   800 NFYLVLFYITLL-----------TLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVL 853

  Fly   879 PRPVAELLKRGDPVEA----ECFDCVTILFSDI----VGFTELCTTSTPFEVVEMLNDWYTCCDS 935
            |..||... .||.:..    :.:|||.::|:.:    |.:||........|.:.:||:
Human   854 PAHVAAHF-IGDKLNEDWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNE------- 910

  Fly   936 IISNYD----------VYKVETIGDAYMVVSGLPLQNGSR---------HAGEIASLALHLLETV 981
            ||:::|          |.|::|||..||..:||.:.:|..         |.|.:...::.|:..:
Human   911 IIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKL 975

  Fly   982 GNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGD------SMRIH 1040
            ..:. ||. ..:.:||:|::.||..|||:|.:.|:|.::|:|||.||||||||:      |:...
Human   976 DGIN-RHS-FNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVSLPFQ 1038

  Fly  1041 ISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWL 1076
            ::|.|..:||.:| |.|..|||.::||||::|||::
Human  1039 VTEETCTILQGLG-YSCECRGLINVKGKGELRTYFV 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	60/317 (19%)
		ANF_receptor	59..427	CDD:279440	56/295 (19%)
		PHA02988	534..826	CDD:165291	54/372 (15%)
		PK_GC-A_B	550..832	CDD:270944	52/362 (14%)
		HNOBA	<847..886	CDD:285003	11/42 (26%)
		CYCc	865..1057	CDD:214485	68/228 (30%)
		Guanylate_cyc	892..1076	CDD:278633	69/216 (32%)
ADCY7	XP_011521137.1	AC_N	<73..249	CDD:292831	14/82 (17%)
		CYCc	224..429	CDD:214485	46/235 (20%)
		Guanylate_cyc	270..432	CDD:278633	33/169 (20%)
		DUF1053	485..592	CDD:283888	21/131 (16%)
		CYCc	848..1052	CDD:214485	65/214 (30%)
		Guanylate_cyc	871..1073	CDD:278633	69/211 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910