DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and ADCY6

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	654	Identity:	150/654 - (22%)
Similarity:	243/654 - (37%)	Gaps:	223/654 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 KKLDWRYLVSGP--LCALVV---VVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTN 551
            :|:|.|:   |.  .|||:|   :..|.|||..:                  :.:.||.|
Human   663 RKVDPRF---GAYVACALLVFCFICFIQLLIFPH------------------STLMLGIY----- 701

  Fly   552 KNIFQICRQSILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENII 616
            .:||.:...::|:....:..|....||.|               ::|||      :|...|...:
Human   702 ASIFLLLLITVLICAVYSCGSLFPKALQR---------------LSRSI------VRSRAHSTAV 745

  Fly   617 NFIGASTDHGSVIIFTT--------------YCARGSLE----DVLA------NEDLHLD----- 652
            .....      :::||:              .||...|.    |:.|      |..|.||
Human   746 GIFSV------LLVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCE 804

  Fly   653 ---------HMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQ 708
                     ..||.:::..:|...::||                        ||..|
Human   805 GTMPTCSFPEYFIGNMLLSLLASSVFLH------------------------ISSIG-------- 837

  Fly   709 EEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQ 773
                      |.|:                     ::..| |:|.::...|| ..|.:...:::.
Human   838 ----------KLAM---------------------IFVLG-LIYLVLLLLGP-PATIFDNYDLLL 869

  Fly   774 FVKCPEMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLV-----RMHLKELQAGL 833
            .|       ||:.....|...||.|...|..|       ..:.|.|.||     .:|.:::::..
Human   870 GV-------HGLASSNETFDGLDCPAAGRVAL-------KYMTPVILLVFALALYLHAQQVESTA 920

  Fly   834 KPNIFDNMLSIMEK------YAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELL----KR 888
            :.:....:.:..||      .|||..                   ||:.:||:.||...    :|
Human   921 RLDFLWKLQATGEKEEMEELQAYNRR-------------------LLHNILPKDVAAHFLARERR 966

  Fly   889 GDPVEAECFDCVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSIISN---YDVYKVE 946
            .|.:..:..:||.::|:.|..|:    ||...:...|.:.:||:.....|.|||.   ..:.|::
Human   967 NDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIK 1031

  Fly   947 TIGDAYMVVSGLPL----QNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAA 1007
            |||..||..|||..    |.|..|...:|..|:.|:|.:.:  |........|::||::.||..|
Human  1032 TIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKH--INEHSFNNFQMKIGLNMGPVVA 1094

  Fly  1008 GVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMR 1072
            ||:|.:.|:|.::|:|||.:|||:|||...||.::...||:|...| |....||:..:||||:|.
Human  1095 GVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKG-YQLECRGVVKVKGKGEMT 1158

  Fly  1073 TYWL 1076
            ||:|
Human  1159 TYFL 1162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	55/334 (16%)
		PK_GC-A_B	550..832	CDD:270944	53/324 (16%)
		HNOBA	<847..886	CDD:285003	10/44 (23%)
		CYCc	865..1057	CDD:214485	67/206 (33%)
		Guanylate_cyc	892..1076	CDD:278633	68/194 (35%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454
		Guanylate_cyc	370..554	CDD:306677
		DUF1053	582..668	CDD:399378	2/4 (50%)
		Guanylate_cyc	970..1164	CDD:306677	69/196 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810