DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc32E and ADCY5

DIOPT Version :9

Sequence 1:NP_001097148.1 Gene:Gyc32E / 34553 FlyBaseID:FBgn0010197 Length:1191 Species:Drosophila melanogaster
Sequence 2:NP_001365188.1 Gene:ADCY5 / 111 HGNCID:236 Length:1286 Species:Homo sapiens


Alignment Length:862 Identity:177/862 - (20%)
Similarity:320/862 - (37%) Gaps:268/862 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   360 GLHLYDSVMIYVRAITEV---LRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTV 421
            |:.:.:::.: ||.:|.|   :|:|  |:.|.:....:..|.:.    |||:  ||.        
Human   541 GMDMIEAISL-VREVTGVNVNMRVG--IHSGRVHCGVLGLRKWQ----FDVW--SND-------- 588

  Fly   422 ITLQNDVGSGASIG--SLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGF 484
            :||.|.:.:|...|  .:.|.::                 .|:..|..:          ||.|| 
Human   589 VTLANHMEAGGKAGRIHITKATL-----------------NYLNGDYEV----------EPGCG- 625

  Fly   485 HGE----------------LCPRKKLDWRYLVS------------GPLCALVVVVAIALLIKHYR 521
             ||                .|.:|:.:.:.:::            .|              .|:.
Human   626 -GERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNP--------------PHWG 675

  Fly   522 YEQT----LAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFRGN 582
            .|:.    |.|.....:||     .:| :.:|.:||            .:.:......:..|.| 
Human   676 AERPFYNHLGGNQVSKEMK-----RMG-FEDPKDKN------------AQESANPEDEVDEFLG- 721

  Fly   583 IVAMKKIHKKSVDITRS--IRKELKLMREVRHEN----------------------IINFIGAST 623
                :.|..:|:|..||  :||.|...||...|.                      .|.|:..:.
Human   722 ----RAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITI 782

  Fly   624 DHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRS--SNC 686
            ...|:.:.:.|.....|..::         :|:|.:.|.:   .::....:.:|...:||  ::.
Human   783 VPHSIFMLSFYLTCSLLLTLV---------VFVSVIYSCV---KLFPSPLQTLSRKIVRSKMNST 835

  Fly   687 LID-------------SRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRG 738
            |:.             :.:.|...|.    |....:|.|.|..::.     |..:...|.....|
Human   836 LVGVFTITLVFLAAFVNMFTCNSRDL----LGCLAQEHNISASQVN-----ACHVAESAVNYSLG 891

  Fly   739 SQKG------------DVYSFGILL----------YEMIGR---------------KGPWGDTAY 766
            .::|            :.:::.:||          ...||:               :.| |.|.:
Human   892 DEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVP-GVTLF 955

  Fly   767 SKEEIIQFVKCPEMLQHGVFR----PALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLK 827
            ...:::......:...:|..:    ..|.|..::...|....:   .::.||     ...::.||
Human   956 DNADLLVTANAIDFFNNGTSQWSLCENLRHRRMEAGTYFPSGV---KEQSPE-----HATKVALK 1012

  Fly   828 ELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLY-----EEKKKTD-------MLLYQMLPR 880
            .    :.|.|....:..:..:|..:|...  |.:.|:     |||::.:       .||:.:||:
Human  1013 V----VTPIIISVFVLALYLHAQQVESTA--RLDFLWKLQATEEKEEMEELQAYNRRLLHNILPK 1071

  Fly   881 PVAELL----KRGDPVEAECFDCVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSII 937
            .||...    :|.|.:..:..:||.::|:.|..|:    ||...:...|.:.:||:.....|.||
Human  1072 DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEII 1136

  Fly   938 SN---YDVYKVETIGDAYMVVSGLPLQN----GSRHAGEIASLALHLLETVGNLK-IRHKPTETV 994
            |.   ..:.|::|||..||..|||....    |..|...:|..|:.|::   .:| |........
Human  1137 SEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMD---QMKYINEHSFNNF 1198

  Fly   995 QLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE 1059
            |::||::.||..|||:|.:.|:|.::|:|||.||||:|||...||.::...||:| ...:|....
Human  1199 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL-AANTYQLEC 1262

  Fly  1060 RGLTSIKGKGDMRTYWL 1076
            ||:..:||||:|.||:|
Human  1263 RGVVKVKGKGEMMTYFL 1279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc32ENP_001097148.1 PBP1_Speract_GC_like 44..448 CDD:107365 21/92 (23%)
ANF_receptor 59..427 CDD:279440 17/69 (25%)
PHA02988 534..826 CDD:165291 54/371 (15%)
PK_GC-A_B 550..832 CDD:270944 52/361 (14%)
HNOBA <847..886 CDD:285003 13/50 (26%)
CYCc 865..1057 CDD:214485 69/214 (32%)
Guanylate_cyc 892..1076 CDD:278633 67/195 (34%)
ADCY5NP_001365188.1 AC_N 1..458 CDD:318454
Guanylate_cyc 460..633 CDD:306677 29/137 (21%)
DUF1053 668..760 CDD:399378 24/128 (19%)
Guanylate_cyc 1087..1281 CDD:306677 68/197 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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