DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc32E and ADCY2

DIOPT Version :9

Sequence 1:NP_001097148.1 Gene:Gyc32E / 34553 FlyBaseID:FBgn0010197 Length:1191 Species:Drosophila melanogaster
Sequence 2:NP_065433.2 Gene:ADCY2 / 108 HGNCID:233 Length:1091 Species:Homo sapiens


Alignment Length:352 Identity:103/352 - (29%)
Similarity:166/352 - (47%) Gaps:79/352 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   786 FRPALTHTHLDI-PDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIM---- 845
            :...|.|||..: .||     .|...|.|.:..|::.:        ..:..:||...|.::    
Human   773 YNTILLHTHAHVLGDY-----SQVLFERPGIWKDLKTM--------GSVSLSIFFITLLVLGRQN 824

  Fly   846 EKYAYNLEGLVQERTNLLYEEKKKTD------------MLLYQMLPRPVAE-LLKR---GDPVEA 894
            |.|.         |.:.|::.|.|.:            :||..:||..||| .|.|   .:.:..
Human   825 EYYC---------RLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYH 880

  Fly   895 ECFDCVTILFSDIVGFTELCTTS----TPFEVVEMLNDWYTCCDSIISNYD----------VYKV 945
            :.:|||.::|:.|..|.|..|.|    ...|.:.:||:       ||:::|          |.|:
Human   881 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNE-------IIADFDDLLSKPKFSGVEKI 938

  Fly   946 ETIGDAYMVVSGL---PLQNGSR-------HAGEIASLALHLLETVGNLKIRHKPT-ETVQLRIG 999
            :|||..||..:||   |.|..|:       |.|.:...|..|   ||.|...:|.: ...:||:|
Human   939 KTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFAL---VGKLDAINKHSFNDFKLRVG 1000

  Fly  1000 VHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTS 1064
            ::.||..|||:|.:.|:|.::|:|||.||||:|||...:|.::|.|..:||.:| |.|..||:.:
Human  1001 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLG-YTCTCRGIIN 1064

  Fly  1065 IKGKGDMRTYWLTKRQQPELTPDLIST 1091
            :|||||::||::.......|:...:::
Human  1065 VKGKGDLKTYFVNTEMSRSLSQSNVAS 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc32ENP_001097148.1 PBP1_Speract_GC_like 44..448 CDD:107365
ANF_receptor 59..427 CDD:279440
PHA02988 534..826 CDD:165291 10/40 (25%)
PK_GC-A_B 550..832 CDD:270944 10/46 (22%)
HNOBA <847..886 CDD:285003 12/51 (24%)
CYCc 865..1057 CDD:214485 75/232 (32%)
Guanylate_cyc 892..1076 CDD:278633 74/208 (36%)
ADCY2NP_065433.2 AC_N <33..260 CDD:292831
CYCc 236..439 CDD:214485
Guanylate_cyc 281..465 CDD:278633
DUF1053 495..599 CDD:283888
CYCc 848..1056 CDD:214485 72/218 (33%)
Guanylate_cyc 878..1077 CDD:278633 74/209 (35%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 905..922 5/23 (22%)
Interaction with GNAS. /evidence=ECO:0000250|UniProtKB:P26769 990..993 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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