Protein Alignment Gyc32E and ADCY1

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_066939.1
• Gene: ADCY1 / 107
• HGNCID: 232
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 1239
• Identity: 253/1239 - (20%)
• Similarity: 428/1239 - (34%)
• Gaps: 404/1239 - (32%)

  Fly    22 CQRSNPLAAGATVSSMRRLTDTINIGFLAEYSQMRVTLGGLPLAIEDVNKNPNLLPGKKLAFKPV 86
            |.....|..|.|:    ||.....:..||..|    .|.| .||:.::...|...||......||
Human    42 CPELEALFRGYTL----RLEQAATLKALAVLS----LLAG-ALALAELLGAPGPAPGLAKGSHPV 97

  Fly    87 DIGHKMSAYRVKPLRAM--TQMREAGVTAFI---------------GPDES--------CTTEAL 126
            .....::...|..:|::  .|:::.|..|.:               ||...        .|.|
Human    98 HCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAE-- 160

  Fly   127 LASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWG 191
             ...|...::             ||.::|  |.|.    :|::::       .|.:||::
Human   161 -QGVWQLLLV-------------TFVSYA--LLPV----RSLLAI-------GFGLVVAA----- 193

  Fly   192 SDVARAIQELAEARNFTISHFKYISDYIPTT-----KTLSQIDKIIEETYATTRIYVFIGEHIAM 251
                              ||....:..:|..     :||.            ....:|:|.::..
Human   194 ------------------SHLLVTATLVPAKRPRLWRTLG------------ANALLFVGVNMYG 228

  Fly   252 VDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKI 316
            | |||.|..|                   |.|:..:..|:.::..:|.|......:....|::.
Human   229 V-FVRILTER-------------------SQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLP- 272

  Fly   317 SMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEVLRLG 381
                      |::..::|:...|.|      :|:|..|.:     ..:|:|.|....|.....|.
Human   273 ----------RNVAMEMKEDFLKPP------ERIFHKIYI-----QRHDNVSILFADIVGFTGLA 316

  Fly   382 GDIYDGNLV--MSHIFNRSYHSIQGFDVYIDSN--------GDAEGNYTVITLQNDVGSGASIGS 436
            .......||  ::.:|.:       ||.....|        ||.  .|.|        ||.:
Human   317 SQCTAQELVKLLNELFGK-------FDELATENHCRRIKILGDC--YYCV--------SGLT--- 361

  Fly   437 LAKMSMQP----------VGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPR 491
                  ||          :|....|..:.:.|...:..:..:....||     .|||..|   .|
Human   362 ------QPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGR-----VLCGVLG---LR 412

  Fly   492 KKLDWRYLV-SGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINL-GEYN------- 547
            |   |:|.| |..:....|:.|              |||..||.:...|:..| |:|.
Human   413 K---WQYDVWSNDVTLANVMEA--------------AGLPGKVHITKTTLACLNGDYEVEPGYGH 460

  Fly   548 ------NPTNKNIFQIC---RQSI---LVVGE--PNKR-SFTNIALFRGNIVAMKKIHKKSVDIT 597
                  ...|...|.|.   |:.|   |::.:  |.|| .|..:......::..:|:.|..:..:
Human   461 ERNSFLKTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFS 525

  Fly   598 RSI-------RKELKLMREVRHENIINFIGASTDHGSVIIFTT-------YCAR--GSLEDVLAN 646
            ..:       |:.|:    ...|.:.|....||:    :::||       |.:|  .:.:..|..
Human   526 NVMTCEDDDKRRALR----TASEKLRNRSSFSTN----VVYTTPGTRVNRYISRLLEARQTELEM 582

  Fly   647 EDLHL------------------DHMFISSLVSDI----LKGMIYL--HDSEIISHGNLRSSNCL 687
            .||:.                  |..|.|::|..:    |.|::||  ....::....|....|.
Human   583 ADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICF 647

  Fly   688 IDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLY 752
            :.:   |.:.   ||..:. |..|....::::..||:...:|  .|...:|...|.:
Human   648 LVA---CVLY---LHITRV-QCFPGCLTIQIRTVLCIFIVVL--IYSVAQGCVVGCL-------- 695

  Fly   753 EMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPAL-------THTHLDIPDYIRKCLCQCWD 810
                   ||..::.....::       :|..|..|.||       ||..|         || |..
Human   696 -------PWAWSSKPNSSLV-------VLSSGGQRTALPTLPCESTHHAL---------LC-CLV 736

  Fly   811 EDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEG--------------------- 854
            ....:....|:..:....|.:||.    .:.:.::|...|...|
Human   737 GTLPLAIFFRVSSLPKMILLSGLT----TSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCA 797

  Fly   855 ------LVQERTNLLY-----EEKKKTDM---------LLYQMLPRPVAELLKRGDP----VEAE 895
                  .|..|..|.|     .|:::.||         :|:.:||..||:.....:|    :..:
Human   798 LALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQ 862

  Fly   896 CFDCVTILFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSIISN---YDVYKVETIGDAYM 953
            .:..|.::|:.|..|.    ||...:...|.:.:||:.....|.::..   .|:.|::|||..||
Human   863 SYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYM 927

  Fly   954 VVSGLPLQNG-------SRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVG 1011
            ...||...:|       |.|...:|..|:.:.:.:.  :|.::......||:|::.||..|||:|
Human   928 AAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLD--EINYQSYNDFVLRVGINVGPVVAGVIG 990

  Fly  1012 QKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIG-SYVCIERGLTSIKGKGDMRTYW 1075
            .:.|:|.::|:|||.||||:|||...||.::|..::||:... .:||  ||..|:||||:|.||:
Human   991 ARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVC--RGKVSVKGKGEMLTYF 1053

  Fly  1076 LTKR 1079
            |..|
Human  1054 LEGR 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	77/453 (17%)
		PK_GC-A_B	550..832	CDD:270944	61/337 (18%)
		CYCc	865..1057	CDD:214485	61/219 (28%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		AcyC	100..456	CDD:441717	90/512 (18%)
		Guanylate_cyc	294..476	CDD:425528	48/237 (20%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		5/26 (19%)
		Guanylate_cyc	859..1056	CDD:425528	65/200 (33%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		9/24 (38%)