Protein Alignment Gyc32E and gucy2d

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_002942678.2
• Gene: gucy2d / 100496590
• XenbaseID: XB-GENE-1014102
• Length: 1081
• Species: Xenopus tropicalis
• Alignment Length: 1191
• Identity: 364/1191 - (30%)
• Similarity: 544/1191 - (45%)
• Gaps: 289/1191 - (24%)

  Fly    13 CILVLLLLGCQRSNPLAAGATVSSMRRLTDTINIGFLAEYSQMRVTLGGLP-----LAIEDVNKN 72
            |..||||       |..|         .|.|..||.:..::........||     |||.|:||:
 Frog    26 CFFVLLL-------PKIA---------WTATFQIGLVGPWTCDPFLAKALPKVAAQLAISDLNKD 74

  Fly    73 PNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDES--CTTEALLASAWNTPM 135
            .:|..|....:..:..|.....    .|.|.|.| |...|||:||...  |::.:|||..||.||
 Frog    75 RSLSSGLWFDYLLLTQGCSTPL----ALAAFTHM-ENSATAFVGPANPGYCSSASLLAKGWNKPM 134

  Fly   136 LSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDVARAIQE 200
            :|:.|:.              .|:|.......:.|:...|.|...:||...:..|
 Frog   135 VSWSCTG--------------VLSPLPYPVDVLYSVFKFFRWAGVAIVTGPQDHW---------- 175

  Fly   201 LAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLE 265
                                                        ||..:.:.|.:||..    :.
 Frog   176 --------------------------------------------IGAGMELGDALRGWG----IP 192

  Fly   266 SGDYIVVSVDDEIYDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHI---- 326
            .|..||                ||.....|      .::|.:|.:|..:|:.:....:..|
 Frog   193 VGPVIV----------------MEGGAEGP------KEALKRIKWRQRVKVVVMCMHSVLIGGED 235

  Fly   327 -RDICSKIKD--YARKTPFLVPY--------HQRVFDNISVPIYG-----LHLYDSVMIYVRAI- 374
             |.:..:..|  .|..:...:||        :.|:|     |::.     ...||:|:....:.
 Frog   236 QRRLLEEAHDMRMADGSVVFIPYDTLQFSLPYDRIF-----PVFTNNTKLRRAYDAVLTITASSE 295

  Fly   375 -----------------------TEVLRLGGDIYDGNLVMSHIFNRSYHSIQ------------- 403
                                   |||..|...||:...::....:|||.:.|
 Frog   296 HGNFYETFQDAKARHEVPQDIDPTEVSPLFATIYNSIYLLGATADRSYQATQRVTASSTTRHAKN 360

  Fly   404 ------GFDVYIDSNGDAEGNYTVI-------------TLQNDVGSGASIGSLAKMSMQPVGF-F 448
                  |:.|.:|.:||::.|:.::             |.|:..|.        .:..:.:.| :
 Frog   361 IQLEGFGYPVNLDEDGDSQTNFVILDTDGESRRLFPVYTFQSATGD--------LIFRRDIHFPY 417

  Fly   449 AY----------DKNSVI-----PEF---------RYIKNDRPIQWLNGRPPLAEPLCGFHGELC 489
            :|          |:|::.     |.:         .:|.......|.
 Frog   418 SYRIGTDSDCWFDRNTICTGGVDPAYVFLIFILLSSFILIGGSFTWY------------------ 464

  Fly   490 PRKKLDWRYLVSGPLCALVVVVAIALLIKHYR---YEQTLAGLLWKVDMKDVTVINLGEYNNPTN 551
            .|:::.:..|..||....:.:..:..:..|.:   .:.:.:.||.:         ::.:...|.:
 Frog   465 IRRRIHYAKLAKGPNKIFLTMEDLTFIHSHSKKKVVDDSRSSLLGR---------SVSDMRTPRH 520

  Fly   552 KNIFQICRQSILVVGEPNKRSFTNIALFRGNIVAMKKI-HKKSVDITRSIRKELKLMREVRHENI 615
                .:..:|:......|    |||.:|.|:.|.:||. .:|..|:..:.:.....:||:|||||
 Frog   521 ----SVSGKSVAAATPHN----TNIGVFEGDWVWLKKFPGEKHGDLRPATKNVFCKLRELRHENI 577

  Fly   616 INFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGN 680
            ..::|...|.|.:.:.:.:|:||||||::.|:|:.||.||.|||:.|::||:.:||..| :.||.
 Frog   578 NLYLGLFDDIGVIGVVSEHCSRGSLEDLIQNQDMKLDWMFKSSLLLDLIKGLKFLHHRE-LPHGR 641

  Fly   681 LRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVY 745
            |:|.||::|.|:|.:::|||::||...|..|: ::|:.:.....||||||||....||:.:||:|
 Frog   642 LKSRNCVVDGRFVLKLTDFGMNELYDAQRLPS-TQLQPEDLFWTAPELLRDATLCQRGTYRGDIY 705

  Fly   746 SFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLD-IPDYIRKCLCQCW 809
            ||.|::.|:|.|..|:.....:.:|||:.|..|..|    .||:::   || .|....:.:..||
 Frog   706 SFAIIMQEVIVRGPPYCMLEVTADEIIRKVLRPPPL----CRPSVS---LDQAPPECIQLMKLCW 763

  Fly   810 DEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLL 874
            .|.||.||.|..:....|.:..|.|.||.|:||.::|:|:.|||.|::|||..|..||:|||.||
 Frog   764 SEQPERRPTIDQIFDQFKNINRGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVEKQKTDKLL 828

  Fly   875 YQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISN 939
            .||||..|||.||.|.|||.|.||.|||.||||||||.:.:.|.|.|||::|||.||..|:||.:
 Frog   829 TQMLPPSVAEALKTGTPVEPEYFDEVTIYFSDIVGFTTISSLSDPIEVVDLLNDLYTLFDAIIGS 893

  Fly   940 YDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGP 1004
            :||||||||||||||.||||..||:|||.|||:::|.:|.:||:.|:||.|...|::|||:||||
 Frog   894 HDVYKVETIGDAYMVASGLPKTNGNRHAAEIANMSLDILSSVGSFKMRHMPDVPVRIRIGLHSGP 958

  Fly  1005 CAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGK 1068
            |.|||||..|||||||||||||||||||||...|:|::.:|..:|..:......| ||.|.:|||
 Frog   959 CVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRVHVNLSTVTILHSLKEGYRFEVRGKTELKGK 1023

  Fly  1069 GDMRTYWLTKRQ---QPELTP 1086
            |...||||..::   :|..||
 Frog  1024 GVEDTYWLVGKEGFTKPLPTP 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593	88/487 (18%)
		PK_GC-A_B	550..832	CDD:270944	101/283 (36%)
		CYCc	865..1057	CDD:214485	120/191 (63%)
gucy2d	XP_002942678.2	PBP1_sensory_GC_DEF-like	43..411	CDD:380594	87/479 (18%)
		PK_GC-2D	519..786	CDD:270945	101/283 (36%)
		HNOBA	<795..840	CDD:462234	26/44 (59%)
		CYCc	820..1012	CDD:214485	120/191 (63%)