Protein Alignment Gyc32E and adcy1

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_002933461.1
• Gene: adcy1 / 100492373
• XenbaseID: XB-GENE-950909
• Length: 1122
• Species: Xenopus tropicalis
• Alignment Length: 1128
• Identity: 232/1128 - (20%)
• Similarity: 419/1128 - (37%)
• Gaps: 356/1128 - (31%)

  Fly   201 LAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGL----QNR 261
            ||....|.:|    :|..|.|..::|...|.:..|.....| :|:..:::.| |||.|    |.:
 Frog   173 LAIVFGFMVS----VSHIIVTATSISPKKKRLWRTLVVNAI-LFVSVNLSGV-FVRILTERAQRK 231

  Fly   262 RLLESGDYIV--VSVDDEIYDSNRRV------NI---MERNYLDP--------YIRKEKSKSL-- 305
            ..|::.:.|.  :.::||.....|.:      |:   |:.::|.|        ||::..:.|:
 Frog   232 AFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILF 296

  Fly   306 -DKISFRSV-------------------------------IKI---------SMTYPQNPHIRDI 329
             |.:.|.|:                               |||         .:|.|:..|.. .
 Frog   297 ADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAH-C 360

  Fly   330 CSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEV---LRLGGDIYDGNLVM 391
            |.::                          ||.:.|::.....| |||   :|:|  ::.|.::.
 Frog   361 CVEM--------------------------GLDMIDTITSVAEA-TEVDLNMRVG--LHTGRVLC 396

  Fly   392 SHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGS--LAKMSMQPVG-------F 447
            ..:..|.:.    :||:  ||.        :||.|.:.:|...|.  :.|.:::.:.       .
 Frog   397 GVLGLRKWQ----YDVW--SND--------VTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPG 447

  Fly   448 FAYDKNS-----------VIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHG----ELCPRKKLDWR 497
            :.:::||           ::|..|     |.|               |.|    ::.|.|::.::
 Frog   448 YGHERNSFLKKHNIETFFIVPSHR-----RKI---------------FPGLILSDIKPAKRMKFK 492

  Fly   498 YLVSGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSI 562
                 .:|.|:|      .:.|.|       .::|.::....|:...:.:.          |:::
 Frog   493 -----TVCYLLV------QLMHCR-------KMFKAEIPFSNVMTCEDDDK----------RRAL 529

  Fly   563 LVVGEP--NKRSF-TNIALFRGNIVAMKKIHK-KSVDITRSIRKELKLMREVRHENIINFIGAST 623
            ....|.  |:.|| ||:            ||. ....:.|.|.:.::..:.....:.:|||....
 Frog   530 RTASEKLRNRSSFSTNV------------IHNTPGTRVNRYIGRLIEARQTDSEMSDLNFITLKY 582

  Fly   624 DHGSVIIFTTYCARGSLEDVLANEDLHLDHMFIS----SLVSDILKGMIYL---HDSEIISHGNL 681
            .|              :|.......|| |..|.|    ||:...|.|::||   ..|.|:.   :
 Frog   583 KH--------------IEREQKYHQLH-DEYFTSAVVLSLILAALFGLVYLLIFPQSTIVL---I 629

  Fly   682 RSSNCL------IDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQ 740
            ....||      |....|.::..|           |....::::..||:...:|  .|...:|..
 Frog   630 LLVFCLCFLVACIMYLHVTRVQCF-----------PGCLTIQIRTILCIFIVIL--IYSVAQGCV 681

  Fly   741 KGDV-------YSFGILLYEMIGRKGPWG----DTAYSKEEIIQFVKC----------------P 778
            .|.:       .|..|::....|......    |||:     ..|:.|                |
 Frog   682 VGCMPWIWRSNNSSSIVIITPKGENKTMNERPCDTAH-----YTFLSCVVGTLSLAIFLRISSFP 741

  Fly   779 EMLQHGVFRPALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLS 843
            :|:.. :|...|....|:|..| ||.|   ..:...:|....::.:.|......|.....|..|.
 Frog   742 KMVLL-LFVTILYIVILEISGY-RKTL---GGDTSYMRGYEPILAILLFSCSLALHSRQVDLKLR 801

  Fly   844 IMEKYAYNLEGLVQERTNLLYEEKKKTD--MLLYQMLPRPVAELLKRGDP----VEAECFDCVTI 902
            :...:|...|   :||.::   |:.|.|  .:|:.:||..||:.....:|    :..:.:..|.:
 Frog   802 LDYLWAVQAE---EERDDM---ERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGV 860

  Fly   903 LFSDIVGFT----ELCTTSTPFEVVEMLNDWYTCCDSIISN---YDVYKVETIGDAYMVVSGLPL 960
            :|:.|..|.    ||...:...|.:.:||:.....|.::..   .|:.|::|||..||...||..
 Frog   861 MFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKECYKDIEKIKTIGSTYMGAVGLVP 925

  Fly   961 QNGSR-------HAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYC 1018
            ..|::       |...:|..::.:.:.:.  :|.::......||:|::.||..|||:|.:.|:|.
 Frog   926 TTGTKAKKSIYSHLSTLADFSIEMFDVLD--EINYQSYNEFVLRVGINVGPVVAGVIGARRPQYD 988

  Fly  1019 LFGDTVNTASRMESTGDSMRIHISEATYQLLQVIG-SYVCIERGLTSIKGKGDMRTYWLTKRQQP 1082
            ::|:|||.||||:|||...:|.::|..:::|:... .:||  ||..|:||||:|.||:|..:
 Frog   989 IWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVC--RGKVSVKGKGEMLTYFLEGK--- 1048

  Fly  1083 ELTPDLISTVDTLDTYCSGPRE-SMEVSVHQYCSPASNNYRLGSCNCDTKCLYSRRSDDNVTNSH 1146
                        :|...|..|. ::|..::.|          |..|..||...|..:..:::|
 Frog  1049 ------------IDGTNSQTRSLNLERKMYPY----------GRTNIQTKLGTSCPAVSSISN-- 1089

  Fly  1147 GTSEFPKVS-----EPAQVNCNQ 1164
                ||..:     :|...:.||
 Frog  1090 ----FPVKAGQGALQPTTSHANQ 1108

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	61/324 (19%)
		ANF_receptor	59..427	CDD:279440	57/294 (19%)
		PHA02988	534..826	CDD:165291	61/335 (18%)
		PK_GC-A_B	550..832	CDD:270944	61/325 (19%)
		HNOBA	<847..886	CDD:285003	12/40 (30%)
		CYCc	865..1057	CDD:214485	57/212 (27%)
		Guanylate_cyc	892..1076	CDD:278633	60/198 (30%)
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	27/114 (24%)
		CYCc	248..443	CDD:214485	41/238 (17%)
		Guanylate_cyc	284..466	CDD:278633	36/225 (16%)
		CYCc	817..1028	CDD:214485	57/215 (27%)
		Guanylate_cyc	850..1047	CDD:278633	61/200 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910