DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and npr2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_031750866.1	Gene:	npr2 / 100488543	XenbaseID:	XB-GENE-993191	Length:	1083	Species:	Xenopus tropicalis

Alignment Length:	1116	Identity:	400/1116 - (35%)
Similarity:	585/1116 - (52%)	Gaps:	131/1116 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CILVLLLLGCQRSNPLAAGATVSSMRRLTDTINIGFLAEYSQMRVTLGGLPLAIEDVNKNPNLLP 77
            |.|:|.|....||:....|....::..:....||.:  .:|..||. ..|.:|::.......|||
Frog    37 CFLLLFLRCPSRSHQSVTGNQTLTLAVVLPESNIRY--AWSWPRVA-PALRMAMDRAQGELQLLP 98

  Fly    78 G--KKLAFKPVDIGHKMSAYRVKPLRAMTQMREAGVTAFIGPDESC----TTEALLASAWNTPML 136
            |  .|..|...::....|.| |.||.|:............||  .|    .:.|..|:.|..|::
Frog    99 GYQVKWVFLTSELNGACSEY-VAPLNAVDLKLYHNPDVLFGP--GCVYPSASVARFATHWRLPLI 160

  Fly   137 S-------FKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAFHWNKFSIVV------SSKP 188
            :       ||..|      ..::|..||...|.|:.:.|..|...|:|:..:.:|      ..:|
Frog   161 TAGALAFGFKQDD------DHYNTTVRTGPTAIKLGEFVSHLHEHFNWSSRAALVYHDVKMDDRP 219

  Fly   189 ----IWGSDVARAIQELAEARNFTISHFKYISDYIPTTKTLSQIDKIIEETYATTRIYVFIGEHI 249
                |.|  |..|:.:  |..|.|:|:..|..|        ..|..:|:....:.|: ::|...:
Frog   220 HYFIIEG--VFLALNK--EFNNLTVSYQMYPED--------EDIGSVIQFIQNSGRV-IYICGPL 271

  Fly   250 AMVDFVRGLQNRRLLESGDYIVVSVDDEIY-DSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSV 313
            .|:..:.....|..|..|||:...||  :: :|.|.....|.|  .|: :...|:.| |.:|::|
Frog   272 EMLHLIMLQAQREKLTDGDYVFFYVD--VFGESLRADGAREAN--KPW-QGNHSQEL-KEAFKTV 330

  Fly   314 IKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQRVFDNISVPIYGLHL------------YDS 366
            :.||...|:|....:...|:...:::.                  :|:.|            :|.
Frog   331 LVISYHQPENAEYFEFQKKLIQKSKEE------------------FGVELNFSLMNFIAGCFHDG 377

  Fly   367 VMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSG 431
            |::|.:|:.|.||.||...||..::..|.:|....|.| .|.:|.|.|...::.:..: .|...|
Frog   378 VLLYAQALNETLREGGSQKDGLSIVKKIQDRQMEGITG-TVSMDKNNDRNTDFDLWAM-TDHNEG 440

  Fly   432 ASIGSLAKMSMQPVGFFAYDKNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGE--LCPRKKL 494
                     |.:.||.:    |.:..:..:  ..:||.||.|.||...|.|.|:.:  .|.:..:
Frog   441 ---------SFEVVGHY----NGINKQINW--TGKPILWLKGSPPSDSPPCVFNADDPSCLKTTV 490

  Fly   495 DWRYLVS--GPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQI 557
            ....:|:  ..|..|:..::..|:::....|:.||.:||::..:::...|...|:......:...
Frog   491 STLAIVALGAGLTLLIFGMSSFLILRKLMLEKELASMLWRIRWEELQFGNSERYHKTAGSRLTLS 555

  Fly   558 CRQS---ILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFI 619
            .|.|   .|:......:.|.|...|:||:||:|.::||.:::||.:..|||.||:|:..::..|:
Frog   556 LRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFL 620

  Fly   620 GASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSS 684
            ||..|..::.|.|.||.||||:|:|.||.::||.||.:||::||:|||.:||.|.|.|||||:||
Frog   621 GACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSS 685

  Fly   685 NCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGI 749
            ||::|||:|.:|:|:||...::..|..:...|..|: |..||||||....|..|:||||||||||
Frog   686 NCVVDSRFVLKITDYGLASFRSSCEADDAYALYAKK-LWTAPELLRMTRPPAPGTQKGDVYSFGI 749

  Fly   750 LLYEMIGRKGPWGDTAY------SKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRK---CL 805
            :|.|:..|.|.:    |      |.:||:|.|:..   |...|||.     :||..:..:   .:
Frog   750 ILQEIALRNGCF----YIQGMDLSPKEIVQKVRNG---QRPYFRPT-----VDISCHSEELGILM 802

  Fly   806 CQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKT 870
            .:||.|:|..|||...::.::.:.......:|.||:||.||:||.|||.||:|||....|||:|.
Frog   803 DRCWAEEPLDRPDFNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKA 867

  Fly   871 DMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDS 935
            :.||||:||..|||.||||:.|:||.||.|||.||||||||.:...|||.:||.:|||.|||.|:
Frog   868 ENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDA 932

  Fly   936 IISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGV 1000
            ||.|:|||||||||||||||||||::||..|..|||.::|.|||.|...||||:|...::||||:
Frog   933 IIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGI 997

  Fly  1001 HSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSI 1065
            |:||..|||||.||||||||||||||||||||.|:::|||||.||.::|.....:....||...:
Frog   998 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEM 1062

  Fly  1066 KGKGDMRTYWL 1076
            ||||.||||||
Frog  1063 KGKGKMRTYWL 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	103/439 (23%)
		ANF_receptor	59..427	CDD:279440	93/403 (23%)
		PHA02988	534..826	CDD:165291	116/303 (38%)
		PK_GC-A_B	550..832	CDD:270944	114/293 (39%)
		HNOBA	<847..886	CDD:285003	23/38 (61%)
		CYCc	865..1057	CDD:214485	124/191 (65%)
		Guanylate_cyc	892..1076	CDD:278633	117/183 (64%)
npr2	XP_031750866.1	PBP1_NPR_B	60..458	CDD:380607	104/463 (22%)
		PK_GC-A_B	555..829	CDD:270944	114/286 (40%)
		HNOBA	<835..883	CDD:400168	29/47 (62%)
		CYCc	862..1046	CDD:214485	123/183 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010