Protein Alignment Gyc32E and gucy2c

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_002934756.1
• Gene: gucy2c / 100486678
• XenbaseID: XB-GENE-952210
• Length: 1064
• Species: Xenopus tropicalis
• Alignment Length: 1120
• Identity: 329/1120 - (29%)
• Similarity: 498/1120 - (44%)
• Gaps: 238/1120 - (21%)

  Fly    44 INIGFLAEY----SQMRVTLGGLPLAIEDVNKNPNLLPGKKLAFKPVDIGHKMSAYRVKPLRAMT 104
            ||:...|::    :.:....|.:..|.|.|.|..||....||.
 Frog    68 INVTLTADFQIFSTDLYANSGCISSACEGVEKLKNLRDTGKLG---------------------- 110

  Fly   105 QMREAGVTAFIGPDESCTTEALLA--SAWNTPMLS-----FKCSDPIVSNKSTFHTF-ARTLAPA 161
                   ...:||..|..|..:|:  :.:..|::|     ..|.         :|.: ||.|.||
 Frog   111 -------CVILGPTCSYATYQMLSLKNTFGVPLISAGSFGLSCD---------YHRYLARILLPA 159

  Fly   162 SKVSKSVISLLNAFHWNKFSIVVSSKPIWGSDVARAIQELAE-------ARNFTISHFKYISDYI 219
            .|::    .....| | :|..|:..|. |.|..........|       |.:..:|:|....::.
 Frog   160 RKMT----YFFKEF-W-QFEGVIKPKK-WQSVYIYKKDGNTESCFWYINALDTGVSYFNSALNFK 217

  Fly   220 PTTKTLSQIDKIIEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRR 284
            ...:|.:::.|::::. ..:.:.:..|.    ...:..|.|:..:.. |.:.:.:|
 Frog   218 EILRTEAELLKVLQDK-RKSNVIIMCGR----PSDIWNLHNKVAIPQ-DMVFILID--------- 267

  Fly   285 VNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFLVPYHQR 349
              |....|.|.                   |.|..|.||..:..|              .|.|..
 Frog   268 --IFNTGYYDN-------------------KSSHHYMQNVLVVTI--------------RPSHMS 297

  Fly   350 VFDN------ISVPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVY 408
            ...|      |.|..|.:...|.|:::...:.:.|: ..||.:....:....|.|.....| .:.
 Frog   298 KLSNTTGIAKILVDDYAVGYLDGVLLFGHTLKKFLK-SPDIKEPFSFIDQFRNISIIGAMG-PLI 360

  Fly   409 IDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYD----KNSVIPEFRYIKNDRPIQ 469
            :|..||.:.|.|:|.      |..:..:..::       ..:|    |.:|:..   :.|   :.
 Frog   361 LDEVGDRDLNLTLIY------SSTATNNYTEL-------IQFDTRTNKTTVMDA---VPN---LI 406

  Fly   470 WLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIALL-----IKHYRYEQTLAGL 529
            |.|.|.|...|..|.|             :::..:..|.|||.:.|:     .:.||.|..|...
 Frog   407 WKNHRLPSDVPQSGPH-------------ILTIAVFTLTVVVILVLITGLLVFRRYRLENELRQK 458

  Fly   530 LWK-VDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSF---TNIALFRGNIVAMKKIH 590
            .|. :..:.:..:|:.|.::.:            |.:.:..:|..   ..|..:...:|.:|.:
 Frog   459 KWSHISPEKILPLNMTETSHVS------------LKIDDDKRRDSGPRLQIRKYDKKVVILKDL- 510

  Fly   591 KKSVDITRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDL------ 649
            |...:.|...:.||..:.::.:.|:..|.|.......:.....||.:|||.||| |:::
 Frog   511 KHDGNFTEKQKMELNKLLQIDYYNLTKFYGTVKLDNIIYAVIEYCDKGSLRDVL-NDNISYPDGT 574

  Fly   650 HLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKS 714
            .:|..|..|::.||.|||.|||.|:...||.|:|:||::|.|.|.:|:||      ||     ||
 Frog   575 FMDWEFKISVMYDIAKGMSYLHASKSEVHGRLKSTNCVVDGRMVVKITDF------AG-----KS 628

  Fly   715 ELELKRALCMAPELLRDAYRPGRG-SQKGDVYSFGILLYEMIGRKGPWGDTAY------SKEEI- 771
            .|..::.|..:||.||.     .| ||||||||:|::..|::.||    :|.|      :||:|
 Frog   629 ILSPQKDLWSSPEHLRQ-----EGFSQKGDVYSYGVIAQEIMLRK----ETFYTEQCDDTKEKIS 684

  Fly   772 -IQFVK--CPEMLQHGVFRPAL---THTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKEL- 829
             :|..|  ||       |||.|   |....:|..|:  .:..||:||||.|||.:.:...|.::
 Frog   685 RVQNYKGACP-------FRPDLNLDTANEREIEVYV--LVKSCWEEDPERRPDFKKIENTLSKIF 740

  Fly   830 ---QAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDP 891
               .:....:..|.::..::.|:.|||.||:|||.|...|:.:.|.|.|.:||.||...||....
 Frog   741 SNFHSQTTESYMDTLIRRLQLYSKNLEHLVEERTQLYKAERDRADRLNYLLLPGPVVMSLKETGR 805

  Fly   892 VEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVS 956
            ||.|.|:.|||.||||||||.:|..|.|.|||:||||.|...|.|:.::||||||||||||||||
 Frog   806 VEPEFFEEVTIYFSDIVGFTTICKYSAPMEVVDMLNDMYKNFDHILDHHDVYKVETIGDAYMVVS 870

  Fly   957 GLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFG 1021
            |||.:||:.||.:|:.:||.:|..:|:.::||.|...|.:|||:|||.|||||||.|||||||||
 Frog   871 GLPNRNGNNHAVDISRMALDILCFMGSFELRHLPGLPVWIRIGIHSGSCAAGVVGIKMPRYCLFG 935

  Fly  1022 DTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIE-RGLTSIKGKGDMRTYWLTKRQQPEL- 1084
            |||||||||||||..:|||::::|..:|:........| ||.|.:||||...|||||...:.:.
 Frog   936 DTVNTASRMESTGLPLRIHVNKSTISILKRTDCEFRYEVRGETYLKGKGTETTYWLTGETEQKYN 1000

  Fly  1085 --TPDLISTVDTLDT 1097
              ||..:.....|.:
 Frog  1001 IPTPPSVENQQRLQS 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	75/428 (18%)
		ANF_receptor	59..427	CDD:279440	71/388 (18%)
		PHA02988	534..826	CDD:165291	95/314 (30%)
		PK_GC-A_B	550..832	CDD:270944	94/308 (31%)
		HNOBA	<847..886	CDD:285003	18/38 (47%)
		CYCc	865..1057	CDD:214485	110/191 (58%)
		Guanylate_cyc	892..1076	CDD:278633	110/184 (60%)
gucy2c	XP_002934756.1	Periplasmic_Binding_Protein_Type_1	29..407	CDD:299141	79/454 (17%)
		PKc_like	472..741	CDD:304357	96/311 (31%)
		Pkinase	497..732	CDD:278497	91/265 (34%)
		CYCc	779..971	CDD:214485	110/191 (58%)
		Guanylate_cyc	806..993	CDD:278633	112/186 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010