DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc32E and gucy2g

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_009305067.2	Gene:	gucy2g / 100333350	ZFINID:	ZDB-GENE-130531-70	Length:	1127	Species:	Danio rerio

Alignment Length:	1104	Identity:	375/1104 - (33%)
Similarity:	555/1104 - (50%)	Gaps:	154/1104 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 NIGFLAEYSQMRVTLG-GLPLAIEDVNKNPNLLPGK---KLAFKPVDIGHKMSAYRVKPLRA-MT 104
            ||.:  .:|.:|  || .:.:|::.:|.|| .|.|.   ...:...|...|.|      ||. :.
Zfish    45 NISY--PFSLLR--LGSAMQIAMDKINSNP-ALSGNFTFDFVYMDTDCNAKTS------LRGFIE 98

  Fly   105 QMREAGVTAFIGPDESCTTEA----LLASAWNTPMLSFKCSDPIVSNKSTFHTFARTLAPASKVS 165
            |:.|..|:|..||  .|..||    |:||.||.||..|....|.:.|...:.|:.:.:.|..:|.
Zfish    99 QVMEQNVSALFGP--PCPEEAEVTGLIASTWNIPMFGFVGQTPKMDNIQVYDTYIKIVPPLKRVG 161

  Fly   166 KSVISLLNAFHWNKFSIV---------VSSKPIWGSDVARAIQELAEARNFTISHFKYISDYIPT 221
            :.::..|..|.|....::         .|.:.:|.|    ..|:|......|:......||....
Zfish   162 EILLKALEFFGWKHVGMIGGGADANTWDSVEALWKS----VDQQLRSKVTVTMGIKFDTSDLEQA 222

  Fly   222 TKTLSQIDKIIEETYATTRIYVFIG---EHIAMVDFVRGLQNRRL-LESGDYIVVSVDD-EI--- 278
            .:.|..|.|:       .|:.|.:.   :..||:     ::.::| |.||:|:.:.|.. |:
Zfish   223 KRNLQIISKV-------ARVVVVLANAEDSTAMM-----IEAQKLGLMSGEYVFLLVQQFEVSGK 275

  Fly   279 YDSNRRVNIMERNYLDPYIRKEKSKSLDKISFRSVIKISMTYPQNPHIRDICSKIKDYARKTPFL 343
            .|:..:.::.|.|       :...|:.|.:    .:....:|....:. |...:..|..:..||
Zfish   276 VDNLWKTSVSETN-------RTMLKAFDMV----FVLAEKSYDGYDYY-DFFDQAYDKLKGDPF- 327

  Fly   344 VPYHQRVFDNIS----VPIYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRS---YHS 401
                   :.|:|    |..|..:|:|:|::|...:.|..:.|.||..|..::..:.:|:   ::.
Zfish   328 -------YSNLSSVKEVSSYAAYLHDAVLLYAMGLKEAFKSGKDIRHGREIVQKLRDRTSIRFYG 385

  Fly   402 IQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSMQPVGFFAYDKNS--VIPEFRYIKN 464
            ..|. |:.|..|:...:|:|..||.           .:..:|.|....:|.::  :.|..|:..
Zfish   386 ASGL-VHFDEYGERNLDYSVYDLQQ-----------TETLIQFVSVLDFDSHTKMIKPTLRFSN- 437

  Fly   465 DRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWR--------YLVSGPLCALVVVVAIALL-IKHY 520
               |.|.||:||...|.|||..|||     :|.        .||:.||..:..|..|.|| ::..
Zfish   438 ---IVWQNGKPPTDNPSCGFDNELC-----EWLDNEISLLVLLVALPLIGVAAVSLITLLTLQKL 494

  Fly   521 RYEQTL-AGLLWKVDMKDVTVINLGEYNNPTNKNIFQI------C----RQSILVVGEPNKRS-- 572
            |.:..| ....|.::..|:|::     ..|....|..:      |    .||:|.....|.|.
Zfish   495 RLQSRLDESNWWLINYSDITIL-----REPKGTQILSVNTTPSKCGSGGSQSMLSSNSCNTREAI 554

  Fly   573 FTNIALFRGNIVAMKKIHKKSV-DITR-SIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYC 635
            :..:.||:||.|.:|.:..:.: ||.: ||..|..:::|::|||::.|.|...|..:|.|...||
Zfish   555 YATVGLFQGNEVGIKYLKNQIIPDIKKPSIIAEFNMLKEMKHENLVQFFGVCIDPPNVCIVMQYC 619

  Fly   636 ARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISHGNLRSSNCLIDSRWVCQISDFG 700
            .:|||:|||.|.::.||.||..|...||:.||.|:|.|.:.||||||.|.||:|||...::|.||
Zfish   620 KKGSLKDVLGNHEIDLDWMFKLSFAYDIVNGMEYIHKSSLKSHGNLRPSTCLVDSRLQIKLSGFG 684

  Fly   701 LHELKAGQ-------EEPNKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGILLYEMI--G 756
            |.|.|.|.       :.|...|:     ...|||.||:.:.|..|:||||||||.|::.|:|  .
Zfish   685 LWEFKCGTKHRLIPLDSPKYEEM-----YWTAPEFLREIFYPFNGTQKGDVYSFAIIIRELIYST 744

  Fly   757 RKGPWGDTAYSKEEIIQFVKCPEMLQHGVFRPALTHTHLDIPD-YIRKCLCQCWDEDPEVRPDIR 820
            ..||:.|.....:|||:.::.|  :.....||.|:   .||.| .:...:..||.|:|:.||...
Zfish   745 EVGPYHDVHLEPKEIIKQLRTP--MSEEPLRPTLS---ADICDERLIPLIKACWSENPDHRPPFG 804

  Fly   821 LVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKTDMLLYQMLPRPVAEL 885
            .:|..|::.......||.|||::.:||||.:||.:|:|||:.|..||.:.|.||..||||.:|:.
Zfish   805 SIRRQLRDACPESHANILDNMVNKLEKYANHLEEVVEERTSQLTVEKSRADKLLSSMLPRYIADQ 869

  Fly   886 LKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGD 950
            |..|..||...::.|||.||||||||.:|:.|:..|||.:|||.|:..|.||..|||||||||||
Zfish   870 LMAGKSVEPRSYEMVTIFFSDIVGFTTMCSVSSALEVVTLLNDLYSLFDDIIKLYDVYKVETIGD 934

  Fly   951 AYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMP 1015
            ||||.||||:.||:.||.||:::|||.|.::...||||.|.|.:.||||::|||..|||||..||
Zfish   935 AYMVASGLPISNGTLHAEEISTMALHFLSSIKRFKIRHLPNERLALRIGINSGPVVAGVVGSTMP 999

  Fly  1016 RYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKR 1079
            |||||||||||||||||....::||||::|..:|..||::...|||...|||||..:|:||..:
Zfish  1000 RYCLFGDTVNTASRMESNSLPLKIHISQSTADILLTIGTFELEERGDIEIKGKGTQKTFWLLSK 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	98/435 (23%)
		ANF_receptor	59..427	CDD:279440	92/400 (23%)
		PHA02988	534..826	CDD:165291	110/315 (35%)
		PK_GC-A_B	550..832	CDD:270944	108/305 (35%)
		HNOBA	<847..886	CDD:285003	20/38 (53%)
		CYCc	865..1057	CDD:214485	111/191 (58%)
		Guanylate_cyc	892..1076	CDD:278633	108/183 (59%)
gucy2g	XP_009305067.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780