DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and gucy1a2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	424	Identity:	141/424 - (33%)
Similarity:	193/424 - (45%)	Gaps:	107/424 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   693 VCQISDFGLHELKAGQEEP-------NKSELELKRALCMAPELLRDAYRPGRGSQKGDVYSFGIL 750
            |.|:.: ||.  |..:.:|       |..||...|..|....:|.....|           |.|
Zfish   214 VLQVGE-GLR--KQAKTDPHRTLTFSNSFELVSPRIPCSFQNILLRLSTP-----------FTI- 263

  Fly   751 LYEMIGRKGPWGDTAYSKEEI---------------IQFVKCP------EMLQHGVFRPALTHTH 794
                  |..|.|.:...:|::               |.|:..|      |::..|:        |
Zfish   264 ------RTRPDGSSLDCREKVMELKGQMLHLPESNSIMFLGSPRVDRLEELMGRGL--------H 314

  Fly   795 L-DIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQE 858
            | |||.:             :...|:.||....| .|.|||..: |.:.:.:||....||
Zfish   315 LSDIPIH-------------DATRDVILVGEQAK-AQDGLKKRM-DKLKATLEKTHQALE----- 359

  Fly   859 RTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVV 923
                  |||::|..|||.:.|..||:.|.:|.||:|:.||.||:|||||||||.:|...||.:|:
Zfish   360 ------EEKRRTVDLLYSIFPGDVAQRLWQGLPVQAKKFDDVTMLFSDIVGFTAVCAQCTPMQVI 418

  Fly   924 EMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRH 988
            .|||:.||..|......||||:|||||||.|..||..:..| ||..||.:||.::|.  :.::..
Zfish   419 SMLNELYTRFDYQCGILDVYKIETIGDAYCVAGGLHRKIDS-HAKPIALMALKMMEL--SEEVLT 480

  Fly   989 KPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIG 1053
            ...:.::||||:|||...|||||..||||||||:.|..||:.||......|::|..|||||:
Zfish   481 PDGKPIKLRIGIHSGSVLAGVVGVMMPRYCLFGNNVTLASKFESGSHPRCINVSPTTYQLLR--- 542

  Fly  1054 SYVCIERGLTSIKGKGDMRTYWLTKRQQPELTPD 1087
                            |.|::....|.:.|| ||
Zfish   543 ----------------DDRSFTFIPRSRQEL-PD 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	32/161 (20%)
		PK_GC-A_B	550..832	CDD:270944	34/167 (20%)
		HNOBA	<847..886	CDD:285003	13/38 (34%)
		CYCc	865..1057	CDD:214485	92/191 (48%)
		Guanylate_cyc	892..1076	CDD:278633	81/183 (44%)
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810