Protein Alignment Gyc32E and gucy1a2

DIOPT Version :10

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001120379.1
• Gene: gucy1a2 / 100145454
• XenbaseID: XB-GENE-1011801
• Length: 712
• Species: Xenopus tropicalis
• Alignment Length: 737
• Identity: 184/737 - (24%)
• Similarity: 279/737 - (37%)
• Gaps: 239/737 - (32%)

  Fly   489 CPRKKLDWRYLVSGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGE----YNNP 549
            ||..:|.|....|.|               ..::.|.:.|.......:.|.:.:|||    ..:|
 Frog    29 CPLARLCWNGSRSPP---------------QEQHPQPVIGPKRATRRRRVNLDSLGESIRKLTSP 78

  Fly   550 TNKNIFQICRQSILVVGEPNKRSFTNIALFRGNIV----AMKKIHKKSV--------------DI 596
            |.:.|.|..:::              :..:..:::    |.:.:|..||              ||
 Frog    79 TPQTIQQTLQRT--------------LQCYEHHVIGCRDAERNLHNASVRCAYAENSGKEDAEDI 129

  Fly   597 TRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYC----------ARGSLEDVLANEDLHL 651
            :..::....:: .::.|.:....|..        |.:.|          ..|:|.|.....|..|
 Frog   130 SGILQCTANML-GIKFEELQERFGEE--------FFSICFEENERVLRAVGGTLHDFFNGFDALL 185

  Fly   652 DHM--------------FISSLVSD--ILKGMIYLHD---------------------------- 672
            :|:              |:...::|  :|....:||.
 Frog   186 EHIRTSIGRQVTLESPSFLCKELADGTLLLSCFHLHHIVGFAMKGLIKAAGKKIYQLKVEVEQVN 250

  Fly   673 -------SEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMA----- 725
                   .:||..||.   |||......|..::.....|......|:...:.:. ..|.|
 Frog   251 NVNEKPCPDIIRPGNF---NCLTFKIKECDNANLMKAPLLQSSHIPSDLRISIS-TFCRAFPFHL 311

  Fly   726 ---PELLRDAYRPGRGSQ---KGDVY-------SFGI---------------LLYEMIGRKGPWG 762
               |.:|  ..:.|.|.:   |.:|:       ||.|               |....:.|..|..
 Frog   312 MFDPNML--ILQLGEGLRKLIKCEVHKTMQFHDSFEIVSPKISCTFEQVLLRLSTPFVIRNKPDA 374

  Fly   763 DTAYSKEEIIQ---------------FVKCP------EMLQHGVFRPALTHTHL-DIPDYIRKCL 805
            .|..:|:::::               |:..|      |::..|:        || |||.:
 Frog   375 PTFENKDKVMEVKGQMIYVPESSSILFLGSPRVDKLDELMGRGL--------HLSDIPIH----- 426

  Fly   806 CQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKT 870
                    :...|:.||....| .|.|||..: |.:.:.:||....||           ||||||
 Frog   427 --------DATRDVILVGEQAK-AQDGLKKRM-DKLKATLEKTHQALE-----------EEKKKT 470

  Fly   871 DMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDS 935
            ..|||.:.|..||:.|..|..|:|..||.||:|||||||||.:|...||.:|:.|||:.||..|.
 Frog   471 VDLLYSIFPGDVAQQLWEGKSVQARKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDY 535

  Fly   936 IISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGV 1000
            .....|:||||||||||.|.:|| |:..:.||..||.:||.::|.  :.::.......:::|||:
 Frog   536 QCGFLDIYKVETIGDAYCVAAGL-LRQSNSHAKPIALMALKMMEL--SEEVLTPDGRPIKMRIGI 597

  Fly  1001 HSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSI 1065
            |||...|||||.:||||||||:.|..||:.||.....||::|..|||||:
 Frog   598 HSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK--------------- 647

  Fly  1066 KGKGDMRTYWLTKRQQPELTPD 1087
                |...:....|.:.|| ||
 Frog   648 ----DEANFHFVPRSREEL-PD 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_SAP_GC-like	44..448	CDD:380593
		PK_GC-A_B	550..832	CDD:270944	64/415 (15%)
		CYCc	865..1057	CDD:214485	93/191 (49%)
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150	14/70 (20%)
		HNOB	<137..248	CDD:462233	15/119 (13%)
		HNOBA	296..486	CDD:462234	50/226 (22%)
		Guanylate_cyc	492..679	CDD:425528	85/196 (43%)