DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc32E and gucy1a2

DIOPT Version :9

Sequence 1:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	737	Identity:	184/737 - (24%)
Similarity:	279/737 - (37%)	Gaps:	239/737 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 CPRKKLDWRYLVSGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGE----YNNP 549
            ||..:|.|....|.|               ..::.|.:.|.......:.|.:.:|||    ..:|
Frog    29 CPLARLCWNGSRSPP---------------QEQHPQPVIGPKRATRRRRVNLDSLGESIRKLTSP 78

  Fly   550 TNKNIFQICRQSILVVGEPNKRSFTNIALFRGNIV----AMKKIHKKSV--------------DI 596
            |.:.|.|..:::              :..:..:::    |.:.:|..||              ||
Frog    79 TPQTIQQTLQRT--------------LQCYEHHVIGCRDAERNLHNASVRCAYAENSGKEDAEDI 129

  Fly   597 TRSIRKELKLMREVRHENIINFIGASTDHGSVIIFTTYC----------ARGSLEDVLANEDLHL 651
            :..::....:: .::.|.:....|..        |.:.|          ..|:|.|.....|..|
Frog   130 SGILQCTANML-GIKFEELQERFGEE--------FFSICFEENERVLRAVGGTLHDFFNGFDALL 185

  Fly   652 DHM--------------FISSLVSD--ILKGMIYLHD---------------------------- 672
            :|:              |:...::|  :|....:||.
Frog   186 EHIRTSIGRQVTLESPSFLCKELADGTLLLSCFHLHHIVGFAMKGLIKAAGKKIYQLKVEVEQVN 250

  Fly   673 -------SEIISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMA----- 725
                   .:||..||.   |||......|..::.....|......|:...:.:. ..|.|
Frog   251 NVNEKPCPDIIRPGNF---NCLTFKIKECDNANLMKAPLLQSSHIPSDLRISIS-TFCRAFPFHL 311

  Fly   726 ---PELLRDAYRPGRGSQ---KGDVY-------SFGI---------------LLYEMIGRKGPWG 762
               |.:|  ..:.|.|.:   |.:|:       ||.|               |....:.|..|..
Frog   312 MFDPNML--ILQLGEGLRKLIKCEVHKTMQFHDSFEIVSPKISCTFEQVLLRLSTPFVIRNKPDA 374

  Fly   763 DTAYSKEEIIQ---------------FVKCP------EMLQHGVFRPALTHTHL-DIPDYIRKCL 805
            .|..:|:::::               |:..|      |::..|:        || |||.:
Frog   375 PTFENKDKVMEVKGQMIYVPESSSILFLGSPRVDKLDELMGRGL--------HLSDIPIH----- 426

  Fly   806 CQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNLEGLVQERTNLLYEEKKKT 870
                    :...|:.||....| .|.|||..: |.:.:.:||....||           ||||||
Frog   427 --------DATRDVILVGEQAK-AQDGLKKRM-DKLKATLEKTHQALE-----------EEKKKT 470

  Fly   871 DMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEVVEMLNDWYTCCDS 935
            ..|||.:.|..||:.|..|..|:|..||.||:|||||||||.:|...||.:|:.|||:.||..|.
Frog   471 VDLLYSIFPGDVAQQLWEGKSVQARKFDDVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDY 535

  Fly   936 IISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLETVGNLKIRHKPTETVQLRIGV 1000
            .....|:||||||||||.|.:|| |:..:.||..||.:||.::|.  :.::.......:::|||:
Frog   536 QCGFLDIYKVETIGDAYCVAAGL-LRQSNSHAKPIALMALKMMEL--SEEVLTPDGRPIKMRIGI 597

  Fly  1001 HSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGSYVCIERGLTSI 1065
            |||...|||||.:||||||||:.|..||:.||.....||::|..|||||:
Frog   598 HSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLK--------------- 647

  Fly  1066 KGKGDMRTYWLTKRQQPELTPD 1087
                |...:....|.:.|| ||
Frog   648 ----DEANFHFVPRSREEL-PD 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365
		ANF_receptor	59..427	CDD:279440
		PHA02988	534..826	CDD:165291	67/429 (16%)
		PK_GC-A_B	550..832	CDD:270944	64/415 (15%)
		HNOBA	<847..886	CDD:285003	15/38 (39%)
		CYCc	865..1057	CDD:214485	93/191 (49%)
		Guanylate_cyc	892..1076	CDD:278633	80/183 (44%)
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150	14/70 (20%)
		HNOB	<132..248	CDD:377902	15/124 (12%)
		HNOBA	296..486	CDD:369471	50/226 (22%)
		Guanylate_cyc	492..679	CDD:306677	85/196 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910