Protein Alignment Gyc32E and adcy7

DIOPT Version :9

• Sequence 1: NP_001097148.1
• Gene: Gyc32E / 34553
• FlyBaseID: FBgn0010197
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_001106549.1
• Gene: adcy7 / 100127741
• XenbaseID: XB-GENE-1005225
• Length: 1061
• Species: Xenopus tropicalis
• Alignment Length: 1127
• Identity: 238/1127 - (21%)
• Similarity: 424/1127 - (37%)
• Gaps: 363/1127 - (32%)

  Fly   122 TTEALLASAWN-TPMLSFKCSDPIVSNKSTFHTFARTLAPASKVSKSVISLLNAF-HWNKFSI-- 182
            |.::.:..||: .|...|          .||..:  |:.|....:..::|:::.. |....||
 Frog   113 TYDSSVVHAWDQVPFFLF----------ITFSVY--TMLPLGMQACLIVSIISGISHIIVISITV 165

  Fly   183 VVSSKPIWGSDVARAIQELAEA-----RNFTISHFKY-ISD-----YIPTTKTLS-----QIDKI 231
            |:||    ||:.|.|.|.:|.|     .|...::.|| :.|     |..|.|.:.     ::.|.
 Frog   166 VLSS----GSNDAIAFQLMANAVIFLCGNLMGAYHKYHMQDASRDLYSYTVKCIRIKMKLELKKR 226

  Fly   232 IEETYATTRIYVFIGEHIAMVDFVRGLQNRRLLESGDYIVVSVDDEIYDSNRRVNIMERNYLDPY 296
            .:|:...:.:.|:|...:.:     .:|: ||.|:.|             ||:   .:.|:...|
 Frog   227 QQESLLLSVLPVYISMEMKL-----AIQD-RLTETND-------------NRQ---PDNNFHSLY 269

  Fly   297 IRKEKSKSL---DKISF----------RSVIKISMTYPQNPHI--RDICSKIKDY------ARKT 340
            :::.::.|:   |.:.|          ..|:.::..:.:...|  .:.|.:||..      ....
 Frog   270 VKRHQNVSILYADIVGFTRLASDCSPKELVVMLNELFGKFDQIAKENECMRIKILGDCYYCVSGL 334

  Fly   341 PFLVPYHQRVFDNISVPIYGLHLYDSVMIYVRAITEV---LRLGGDIYDGNLVMSHIFNRSYH-S 401
            |..:|.:.:     :....||.:.:::. .||..|..   :|:|  ::.||::...|..|.:. .
 Frog   335 PVSLPNNAK-----NCVKMGLDICEAIK-QVREATGADINMRVG--VHSGNVLCGVIGLRKWQFD 391

  Fly   402 IQGFDVYIDSNGDAEG-----NYTVITLQN-----DVGSGASIGSLAKMSMQPVG---FFAYD-- 451
            :...||.:.:..::.|     :.|..||::     ||..|.  |.|....::.:.   |...|
 Frog   392 VWSHDVSLANRMESAGLPGRVHITEATLKHMNGAYDVEEGH--GELRDPYLKEMNIKTFLVIDPR 454

  Fly   452 -KNSVIPEFRYIKNDRPIQWLNGRPPLAEPLCGFHGELCPRKKLDWRYLVSGPLCALVVVVAIAL 515
             |||.:.. .::...|....:..||.:...                |||.|.         ..|.
 Frog   455 AKNSRVKN-NHLTRHRVNDGIKVRPSVRMT----------------RYLESW---------GAAR 493

  Fly   516 LIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTNKNIFQICRQSILVVGEPNKRSFTNIALFR 580
            ...|  ::||.|      ...:|..:|                       |:|...
 Frog   494 PFSH--FDQTDA------SSTEVPTVN-----------------------GKPKPE--------- 518

  Fly   581 GNIVAMKKIHKKSVDITRSIRKELKLMREVRHENIINFI----------GASTD-HGSVIIFTTY 634
               :.:|.: .::|...|::.:: :...|..|:.::|.|          |.:.| :|.::.||.
 Frog   519 ---IPLKGM-GRTVKTERNVSQK-RNQEEELHDRMMNTIDGLSSAKPWFGKTDDFYGFLLFFTA- 577

  Fly   635 CARGSLEDVLANEDLHLDHMFISS--LVSDILKGMIYLHDSEIISHGNLRSSN------------ 685
                   |.|..|........|.|  |.:.::...|:|....::.    ||:|
 Frog   578 -------DGLEKEYRTFRIPCIQSYFLCASLIFLCIFLIQILVMP----RSANLGISFGVVSVLI 631

  Fly   686 ------CLID--SRWVCQISDFGLHELKAGQEEPNKSELELKRALCMAPELLRDAYRPGRGSQKG 742
                  |.:|  :|:..:.:.|                   .|.||...|::..     |.|.:.
 Frog   632 LWVLLICYVDKCARFCNENAPF-------------------SRFLCSLVEMIET-----RPSLRV 672

  Fly   743 DV--YSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCP--EMLQHGVFRPALTHTHL-DIPDYIR 802
            .:  .:.|.||                   ||..|..|  :.||........|.:.. .||.|:.
 Frog   673 PLVALTLGSLL-------------------IISIVNLPLDQTLQTCNTSSIATESQCQSIPYYVY 718

  Fly   803 KCL-----C-----QCWDEDPEVR----------PDIRLVRMHLKELQAGLKPNI-----FDNM- 841
            .|:     |     .|:    |::          .::.:...|....::.|..:|     |..|
 Frog   719 CCILGLVACSMFLRMCF----ELKILLLTAAFTAYNVIIFHTHSSIFRSNLNSSIGVLEDFQKMS 779

  Fly   842 ---LSIMEKYAYNLEGLVQE-----RTNLLYEEK-KKTD-----------MLLYQMLPRPVAELL 886
               ||:   |...|..|.::     |.:.|::.| :|.|           :||..:||..||...
 Frog   780 CFYLSL---YYLTLVLLARQVEYYSRLDCLWKRKFRKEDEEIETMENLNQLLLENVLPAHVAAYF 841

  Fly   887 ----KRGDPVEAECFDCVTILFSDI----VGFTELCTTSTPFEVVEMLNDWYTCCDSIISNYD-- 941
                :..:.:..:.:|||.::|:.:    |.:||........|.:.:||:       ||:::|
 Frog   842 IDDNRSNEDLYHQSYDCVCVMFASVPEFKVFYTECDVNKEGLECLRLLNE-------IIADFDEL 899

  Fly   942 --------VYKVETIGDAYMVVSGLPLQNG-------SRHA--GEIASLALHLLETVGNLKIRHK 989
                    |.|::|||..||..:||....|       .:||  |.....|:.|:..:..:. ||.
 Frog   900 LMKPKFSGVEKIKTIGSTYMAATGLTATPGQENQDQEKQHALIGITVEYAMALMSKLDGIN-RHS 963

  Fly   990 PTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEATYQLLQVIGS 1054
             ....:||:|::.||..|||:|.|.|:|.::|:|||.||||||||:..:|.::|.|.|:|:.:|
 Frog   964 -FNNFRLRVGINHGPVIAGVIGAKKPQYDIWGNTVNVASRMESTGELGKIQVTEETCQILEGLG- 1026

  Fly  1055 YVCIERGLTSIKGKGDMRTYWL 1076
            |.|..||..::||||::|||::
 Frog  1027 YSCECRGFINVKGKGELRTYFV 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	75/383 (20%)
		ANF_receptor	59..427	CDD:279440	70/359 (19%)
		PHA02988	534..826	CDD:165291	54/349 (15%)
		PK_GC-A_B	550..832	CDD:270944	53/339 (16%)
		HNOBA	<847..886	CDD:285003	14/55 (25%)
		CYCc	865..1057	CDD:214485	70/230 (30%)
		Guanylate_cyc	892..1076	CDD:278633	71/206 (34%)
adcy7	NP_001106549.1	AC_N	<21..266	CDD:318454	42/190 (22%)
		Guanylate_cyc	268..418	CDD:306677	26/157 (17%)
		DUF1053	483..591	CDD:399378	28/185 (15%)
		Guanylate_cyc	851..1048	CDD:306677	71/206 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910