DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hgo and Hgd

DIOPT Version :9

Sequence 1:	NP_523544.2	Gene:	hgo / 34552	FlyBaseID:	FBgn0040211	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001012145.1	Gene:	Hgd / 360719	RGDID:	1308757	Length:	445	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	294/438 - (67%)
Similarity:	344/438 - (78%)	Gaps:	2/438 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEYKYLSGFGSHFSSEDERYPNSLPVGQNSPQVCPYKLYAEQLSGSAFTAPRTENMRTWLYRKL 65
            |:|.||:||||:..:|||.|.|.|||.|||:||:|||.||||||||||||.||..|.|:||||.|
  Rat     1 MAELKYISGFGNECASEDPRCPGSLPKGQNNPQICPYNLYAEQLSGSAFTCPRNTNKRSWLYRIL 65

  Fly    66 PSAAHLPFQPFKGAEYFSQNWDEQPPNPNQLRWKPFDLPPKDGKNVNFVEGLHTVCGAGDPRSRH 130
            ||.:|.||...... :.:.||||..|:|||||||||::|....|.|:||.||||:|||||.||.:
  Rat    66 PSVSHKPFASIDQG-HINHNWDEVGPDPNQLRWKPFEIPKACQKKVDFVSGLHTLCGAGDIRSNN 129

  Fly   131 GLAIHIYSCNGSMDNSAFYNSDGDFLIVPQQGVLDITTEFGRMSVAPNEICVIPQGIRFAVNVDS 195
            |||:||:.||..|:|..|||||||||||||:|.|.|.||||:|.:.|||||||.:|:||:|:|..
  Rat   130 GLAVHIFLCNSPMENRCFYNSDGDFLIVPQKGKLLIYTEFGKMFLQPNEICVIQRGMRFSVDVFE 194

  Fly   196 PSRGYILEVYDDHFVLPDLGPIGANGLANPRDFETPVAWFDDRDVK-DFQVISKFQGRLFVAKQN 259
            .:||||||||..||.||||||||||||||||||..||||::||.|. .|.||:|:||:||.:||:
  Rat   195 ETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPVAWYEDRQVPGGFTVINKYQGKLFASKQD 259

  Fly   260 HTVFDVVAWHGNYVPFKYDLSKFMVINSVSFDHCDPSIFTVLTCPSLRAGTAIADFVIFPPRWSV 324
            .:.|:||||||||.|:||:|..|||||:|:|||.|||||||||..|||.|.||||||||||||.|
  Rat   260 VSPFNVVAWHGNYTPYKYNLENFMVINAVAFDHADPSIFTVLTAKSLRPGVAIADFVIFPPRWGV 324

  Fly   325 QEHTFRPPYYHRNCMSEFMGLILGKYEAKEDGFAAGGATLHSMMTPHGPDVKCFEGASNAKLVPE 389
            .:.|||||||||||||||||||.|.||||:.||..||.:|||.|||||||..|||.||.|||.||
  Rat   325 ADKTFRPPYYHRNCMSEFMGLIKGHYEAKQGGFLPGGGSLHSAMTPHGPDADCFEKASKAKLEPE 389

  Fly   390 RVAEGTQAFMFESSLSLAVTKWGEETCQKLDAAYYECWQALKNNFQIT 437
            |:|:||.||||||||||||||||.:||..||..||:||:.|:.:|..|
  Rat   390 RIADGTMAFMFESSLSLAVTKWGLKTCGCLDEDYYKCWEPLQAHFTPT 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hgo	NP_523544.2	hmgA	3..434	CDD:273395	291/431 (68%)
Hgd	NP_001012145.1	hmgA	3..434	CDD:273395	291/431 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340474
Domainoid	1	1.000	615	1.000	Domainoid score	I177
eggNOG	1	0.900	-	-		E1_COG3508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H156
Inparanoid	1	1.050	621	1.000	Inparanoid score	I843
OMA	1	1.010	-	-		QHG63167
OrthoDB	1	1.010	-	-		D226335at33208
OrthoFinder	1	1.000	-	-		FOG0006563
OrthoInspector	1	1.000	-	-		oto95594
orthoMCL	1	0.900	-	-		OOG6_102821
Panther	1	1.100	-	-	LDO	PTHR11056
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4803
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770