DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hgo and hgd

DIOPT Version :9

Sequence 1:NP_523544.2 Gene:hgo / 34552 FlyBaseID:FBgn0040211 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_694498.2 Gene:hgd / 259189 ZFINID:ZDB-GENE-020802-5 Length:443 Species:Danio rerio


Alignment Length:435 Identity:296/435 - (68%)
Similarity:350/435 - (80%) Gaps:2/435 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSEYKYLSGFGSHFSSEDERYPNSLPVGQNSPQVCPYKLYAEQLSGSAFTAPRTENMRTWLYRKL 65
            |:..||:||||:.|||||.|.|.|||.|||:||||||.||||||||||||.||:.|.|:||||.|
Zfish     1 MAGLKYMSGFGNEFSSEDPRCPGSLPEGQNNPQVCPYGLYAEQLSGSAFTCPRSSNKRSWLYRIL 65

  Fly    66 PSAAHLPFQPFKGAEYFSQNWDEQPPNPNQLRWKPFDLPPKDGKNVNFVEGLHTVCGAGDPRSRH 130
            ||..|.||......: .::||:|..|:|||||||||::|....|.|:||.||||||||||.:||:
Zfish    66 PSVRHKPFTRMSCGD-LTENWNEVEPDPNQLRWKPFNIPKSSEKKVDFVSGLHTVCGAGDSKSRN 129

  Fly   131 GLAIHIYSCNGSMDNSAFYNSDGDFLIVPQQGVLDITTEFGRMSVAPNEICVIPQGIRFAVNVDS 195
            |:|||:||||.||.:..|.|:|||||||||||.:.||||||:|.|.|||||||.||:||:|:|..
Zfish   130 GIAIHMYSCNTSMTDKCFQNADGDFLIVPQQGEILITTEFGKMMVEPNEICVIQQGMRFSVDVFG 194

  Fly   196 PSRGYILEVYDDHFVLPDLGPIGANGLANPRDFETPVAWFDDRDV-KDFQVISKFQGRLFVAKQN 259
            .:|||||||:..||.||||||||||||||||||:|||||::||.: ..:.:::|:||:||..:|:
Zfish   195 ETRGYILEVFGAHFELPDLGPIGANGLANPRDFQTPVAWYEDRTIATGYTIVNKYQGKLFSCQQD 259

  Fly   260 HTVFDVVAWHGNYVPFKYDLSKFMVINSVSFDHCDPSIFTVLTCPSLRAGTAIADFVIFPPRWSV 324
            .:.|:||||||||.|:||:|..|||||.|:|||.|||||||||..|.|.|.||||||||||||.|
Zfish   260 FSPFNVVAWHGNYAPYKYNLENFMVINCVAFDHADPSIFTVLTAKSTRPGVAIADFVIFPPRWGV 324

  Fly   325 QEHTFRPPYYHRNCMSEFMGLILGKYEAKEDGFAAGGATLHSMMTPHGPDVKCFEGASNAKLVPE 389
            .:||||||||||||||||||||.|.|||||:||..||.:|||:||||||||.|||..|.|.|.||
Zfish   325 ADHTFRPPYYHRNCMSEFMGLIKGHYEAKEEGFQPGGGSLHSIMTPHGPDVDCFEKNSTALLKPE 389

  Fly   390 RVAEGTQAFMFESSLSLAVTKWGEETCQKLDAAYYECWQALKNNF 434
            ||||||.|||||||.|:||||||.||||:||..||:||:|||::|
Zfish   390 RVAEGTMAFMFESSFSMAVTKWGLETCQRLDKNYYKCWEALKSHF 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hgoNP_523544.2 hmgA 3..434 CDD:273395 294/431 (68%)
hgdNP_694498.2 homogentisate 1,2-dioxygenase. Homogentisate dioxygenase cleaves the aromatic ring during the metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria. The structure of homogentisate dioxygenase shows that the enzyme forms a hexamer arrangement comprised of a dimer of trimers. The active site iron ion is coordinated near the interface between the trimers 4..434 294/430 (68%)
hmgA 4..434 CDD:273395 294/430 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170580263
Domainoid 1 1.000 597 1.000 Domainoid score I193
eggNOG 1 0.900 - - E1_COG3508
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H156
Inparanoid 1 1.050 618 1.000 Inparanoid score I858
OMA 1 1.010 - - QHG63167
OrthoDB 1 1.010 - - D226335at33208
OrthoFinder 1 1.000 - - FOG0006563
OrthoInspector 1 1.000 - - oto39095
orthoMCL 1 0.900 - - OOG6_102821
Panther 1 1.100 - - LDO PTHR11056
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2561
SonicParanoid 1 1.000 - - X4803
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1615.800

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