DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hgo and hgo-1

DIOPT Version :9

Sequence 1:	NP_523544.2	Gene:	hgo / 34552	FlyBaseID:	FBgn0040211	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_492433.1	Gene:	hgo-1 / 172726	WormBaseID:	WBGene00001843	Length:	437	Species:	Caenorhabditis elegans

Alignment Length:	442	Identity:	297/442 - (67%)
Similarity:	348/442 - (78%)	Gaps:	9/442 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEY---KYLSGFGSHFSSEDERYPNSLPVGQNSPQVCPYKLYAEQLSGSAFTAPRTENMRTWLY 62
            |||:   |||:|||:..::.|.|.|::|||||||||.|.:.||||||||:||||||::|.|:|||
Worm     1 MSEFDELKYLTGFGNEHATSDPRVPDALPVGQNSPQKCSHGLYAEQLSGTAFTAPRSQNQRSWLY 65

  Fly    63 RKLPSAAHLPFQPFK-GAEYFSQNWDEQPPNPNQLRWKPFDLPPKDGKNVNFVEGLHTVCGAGDP 126
            |..||..|.||:..| ..::::.|:...||||||.||.||.||.|:|  |.||:.|:||||.||.
Worm    66 RIRPSVIHRPFEAMKENDQHWTNNFSSIPPNPNQYRWNPFPLPTKEG--VTFVDNLYTVCGGGDV 128

  Fly   127 RSRHGLAIHIYSCNGSMDNSAFYNSDGDFLIVPQQGVLDITTEFGRMSVAPNEICVIPQGIRFAV 191
            .||.|||||.:|||.||:::|.||||||||||||||.|:|||||||:.|.|.||.||||||||:|
Worm   129 ISRTGLAIHQFSCNASMEHTAMYNSDGDFLIVPQQGALEITTEFGRLLVNPQEIAVIPQGIRFSV 193

  Fly   192 NVDSPSRGYILEVYDDHFVLPDLGPIGANGLANPRDFETPVAWFDDRDVKDFQVISKFQGRLFVA 256
            .|..||||||||||..||.|||||||||||||||||||.|||||:|.|| :|.:|:|:||..|.|
Worm   194 AVRGPSRGYILEVYGTHFQLPDLGPIGANGLANPRDFEAPVAWFEDLDV-EFTIINKYQGSWFQA 257

  Fly   257 KQNHTVFDVVAWHGNYVPFKYDLSKFMVINSVSFDHCDPSIFTVLTCPSLRAGTAIADFVIFPPR 321
            ||.|:.||||.|||||||:||||.||||||:|||||||||||||||.||::.|||||||||||||
Worm   258 KQGHSPFDVVGWHGNYVPYKYDLKKFMVINTVSFDHCDPSIFTVLTAPSVKHGTAIADFVIFPPR 322

  Fly   322 WSVQEHTFRPPYYHRNCMSEFMGLILGKYEAKEDGFAAGGATLHSMMTPHGPDVKCFEGASNAKL 386
            |...::||||||||||||||:||||.|.|||||.||..||.:|||||||||||..|||.||||.|
Worm   323 WGCADNTFRPPYYHRNCMSEYMGLITGCYEAKEGGFKPGGGSLHSMMTPHGPDFNCFEMASNADL 387

  Fly   387 VPERVAEGTQAFMFESSLSLAVTKWGEETCQKLDAAYYECWQALKNNFQITK 438
            .|:||||||.:|||||||::|:|.|.  ..|.:|..||:.||.||.:|.:.|
Worm   388 KPQRVAEGTMSFMFESSLNMAITNWA--VYQNVDKDYYKDWQPLKKHFTMPK 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hgo	NP_523544.2	hmgA	3..434	CDD:273395	293/434 (68%)
hgo-1	NP_492433.1	hmgA	6..433	CDD:273395	292/431 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159039
Domainoid	1	1.000	613	1.000	Domainoid score	I88
eggNOG	1	0.900	-	-		E1_COG3508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H156
Inparanoid	1	1.050	616	1.000	Inparanoid score	I488
Isobase	1	0.950	-	0	Normalized mean entropy	S2058
OMA	1	1.010	-	-		QHG63167
OrthoDB	1	1.010	-	-		D226335at33208
OrthoFinder	1	1.000	-	-		FOG0006563
OrthoInspector	1	1.000	-	-		oto20759
orthoMCL	1	0.900	-	-		OOG6_102821
Panther	1	1.100	-	-	LDO	PTHR11056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2561
SonicParanoid	1	1.000	-	-		X4803
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750