Protein Alignment CG4751 and BRCC3

DIOPT Version :10

• Sequence 1: NP_609495.1
• Gene: CG4751 / 34551
• FlyBaseID: FBgn0032348
• Length: 1412
• Species: Drosophila melanogaster
• Sequence 2: XP_005274808.1
• Gene: BRCC3 / 79184
• HGNCID: 24185
• Length: 317
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 53/268 - (19%)
• Similarity: 100/268 - (37%)
• Gaps: 59/268 - (22%)

  Fly   315 MNTHTLSITKTYPCRSTRF----DRQRAGEVERDIQKMMIQDQLLLVGWYHSHPKFQAEPTLRDC 375
            ::.|::.|.:....|..|.    ::..|...|.:....:....:.:||||||||.....|:..|.
Human    73 VHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDV 137

  Fly   376 DAQLDYQIKMRGASDLTYTPCVSLIISPYYDENPTLESVV--KCIWIVPPNENRQSMEYGRPM-- 436
            ..|..||:..:|        .|.||.|.:.::..|....|  .|...:...::.:|:...|..
Human   138 RTQAMYQMMDQG--------FVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSESLHGPRDFWS 194

  Fly   437 -LMQYSVLPDKEIPEEVRSEI-----------QLCVDYYSQY-----RSEMVKFRNIYN----ND 480
             ....|:...||.....|.||           ::|::...:.     :.|...:|.|::    :.
Human   195 SSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDS 259

  Fly   481 VTYNEKLKN-TLYPKFPSKQSDKA---LWNWICAVLDCEQEDDFIPPKTIKIIDNDDLEVKEEDK 541
            ||   |:.| :::.|....|....   |..|:...|:..|:               .|:..:::|
Human   260 VT---KIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQ---------------HLQELQQEK 306

  Fly   542 PVVLMDLS 549
            ..::.:||
Human   307 EELMQELS 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4751	NP_609495.1	RAMA	124..220	CDD:465856
		MPN_2A_DUB	278..463	CDD:163698	36/167 (22%)
		PHA03247	<616..741	CDD:223021
BRCC3	XP_005274808.1	MPN_BRCC36	13..293	CDD:163699	47/230 (20%)