DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4751 and STAMBP

DIOPT Version :10

Sequence 1:NP_609495.1 Gene:CG4751 / 34551 FlyBaseID:FBgn0032348 Length:1412 Species:Drosophila melanogaster
Sequence 2:NP_006454.1 Gene:STAMBP / 10617 HGNCID:16950 Length:424 Species:Homo sapiens


Alignment Length:354 Identity:67/354 - (18%)
Similarity:103/354 - (29%) Gaps:139/354 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   172 TIFLTPSAWAMHCKRIINPDKKSGCGWASVKYKGKKLDAYKNTYLRKCALQKETPLDDCELDAER 236
            |:|:.........|..:.|:||.     :|| |.|:: |:......|..|.|....:..|.:.|:
Human    68 TLFIEKLPKHRDYKSAVIPEKKD-----TVK-KLKEI-AFPKAEELKAELLKRYTKEYTEYNEEK 125

  Fly   237 KTDTPEIVVKRTVFAHNTVSNRNVVHDANMLIESVPF--------------------TSVGKLQP 281
            |.:..|:.....:........:.|.......:|...|                    ...||:.|
Human   126 KKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDP 190

  Fly   282 FL------------------ITVNSSALLLADFHCHLTVR------------------------- 303
            .|                  :||:|    :....||.|||                         
Human   191 GLGGPLVPDLEKPSLDVFPTLTVSS----IQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTI 251

  Fly   304 ----------------------------EVCGYLGGTWDMN----THTLSITKTYPCRSTRFDRQ 336
                                        |.||.|.|....|    ||.|            ..:|
Human   252 DGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVL------------IPKQ 304

  Fly   337 RAG----EVERDIQKMMIQDQ--LLLVGWYHSHPKFQAEPTLRDCDAQLDYQIKMRGASDLTYTP 395
            .||    ..|.:.:..:||||  |:.:||.|:||...|..:..|......||:.:        ..
Human   305 SAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMML--------PE 361

  Fly   396 CVSLIISPYYDE-------NPTLESVVKC 417
            .|:::.||.:.|       :..||.:..|
Human   362 SVAIVCSPKFQETGFFKLTDHGLEEISSC 390

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4751NP_609495.1 RAMA 124..220 CDD:465856 12/47 (26%)
MPN_2A_DUB 278..463 CDD:163698 45/228 (20%)
PHA03247 <616..741 CDD:223021
STAMBPNP_006454.1 Interaction with CHMP3. /evidence=ECO:0000269|PubMed:17146056 1..127 16/65 (25%)
USP8_dimer 13..117 CDD:462647 14/55 (25%)
Interaction with STAM. /evidence=ECO:0000269|PubMed:10383417 227..231 0/3 (0%)
MPN_AMSH_like 254..424 CDD:163697 34/157 (22%)
JAMM motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 335..348 4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

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