DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RfC38 and RFC4

DIOPT Version :9

Sequence 1:	NP_001285833.1	Gene:	RfC38 / 34550	FlyBaseID:	FBgn0028700	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_002907.1	Gene:	RFC4 / 5984	HGNCID:	9972	Length:	363	Species:	Homo sapiens

Alignment Length:	355	Identity:	99/355 - (27%)
Similarity:	163/355 - (45%)	Gaps:	56/355 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WVDKYRPRELSKLDFHKDQAENLRNLCKQSDFPHLMFYGPSGAGKKTRIMCLLREMYGSGVERLR 68
            ||:||||:.:.::.|.::....|:...:.:|.|:|:||||.|.||.:.|:...||::|..:.|||
Human    40 WVEKYRPKCVDEVAFQEEVVAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLR 104

  Fly    69 SETMTFTTPSNRKVEVMTVSSNYHLEVNPSD-AGMYDRTVVIDLIKQVAQTHQIEISGQRE---- 128
            .                       ||:|.|| .|:   .||.:.:|..|   |:.:||.|.
Human   105 V-----------------------LELNASDERGI---QVVREKVKNFA---QLTVSGSRSDGKP 140

  Fly   129 ---FKVIVISEGDELTKDAQHALRRTMEKYVATCRIIISVNSTSRIIPAIRSRCLGIRVAAPNET 190
               ||::::.|.|.:|..||.||||||||...|.|..:..|..||||..:.|||...|....::.
Human   141 CPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCLICNYVSRIIEPLTSRCSKFRFKPLSDK 205

  Fly   191 EIVSILQNTCKREGLALPVELAKRVVDKSERNLRRALLMLEAAKVAKAPFTANQEIPDLDWQVFL 255
            .....|.:..|:|.:.:..|....:|..||.:||:|:..|::|    ...|..:||.    :..:
Human   206 IQQQRLLDIAKKENVKISDEGIAYLVKVSEGDLRKAITFLQSA----TRLTGGKEIT----EKVI 262

  Fly   256 RETASQIISEQ--------TPAKLEKIRERLYELLTQGVPPNLIFRGLVEQLVNNCDMSIKAKTL 312
            .:.|..|.:|:        .....:|:...:.:|:.:|.....:...|.:.:|.| ::|.|.|::
Human   263 TDIAGVIPAEKIDGVFAACQSGSFDKLEAVVKDLIDEGHAATQLVNQLHDVVVEN-NLSDKQKSI 326

  Fly   313 --EFATEYEHRMQSGAKHIFHLEAFVAQFM 340
              |...|.:..:..||.....|.:..|..|
Human   327 ITEKLAEVDKCLADGADEHLQLISLCATVM 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RfC38	NP_001285833.1	rfc	3..345	CDD:234763	99/355 (28%)
RFC4	NP_002907.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
RFC4	NP_002907.1	Rad17	39..353	CDD:330523	97/350 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0470
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1071197at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820