DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RfC38 and RFC2

DIOPT Version :9

Sequence 1:	NP_001285833.1	Gene:	RfC38 / 34550	FlyBaseID:	FBgn0028700	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_852136.1	Gene:	RFC2 / 5982	HGNCID:	9970	Length:	354	Species:	Homo sapiens

Alignment Length:	347	Identity:	90/347 - (25%)
Similarity:	162/347 - (46%)	Gaps:	53/347 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WVDKYRPRELSKLDFHKDQAENLRNLCKQSDFPHLMFYGPSGAGKKTRIMCLLREMYGSGVERLR 68
            ||:||||.:|:::..::|....|....::.:.|:::..||.|.||.|.|:||.|.:.|..::
Human    38 WVEKYRPVKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALK--- 99

  Fly    69 SETMTFTTPSNRKVEVMTVSSNYHLEVNPS-DAGMYDRTVVIDLIKQVAQTHQIEISGQREFKVI 132
                          :.|       ||:|.| |.|:   .||.:.||..||.......|:.  |:|
Human   100 --------------DAM-------LELNASNDRGI---DVVRNKIKMFAQQKVTLPKGRH--KII 138

  Fly   133 VISEGDELTKDAQHALRRTMEKYVATCRIIISVNSTSRIIPAIRSRCLGIRVAAPNETEIVSILQ 197
            ::.|.|.:|..||.|||||||.|..|.|..::.|::.:||..|:|||..:|.....:.:|::.|.
Human   139 ILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLM 203

  Fly   198 NTCKREGLALPVELAKRVVDKSERNLRRALLMLEAAKVAKAPFTA----NQE----IPDLDWQVF 254
            |..::|.:....:..:.::..::.::|:||..|::.      |:.    |.|    :.|....:.
Human   204 NVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQST------FSGFGFINSENVFKVCDEPHPLL 262

  Fly   255 LRETASQIISEQTPAKLEKIRERLYELLTQGVPPNLIFRGLVEQLVNNCDMSIKAKTLEFATE-- 317
            ::|.....::    |.:::..:.|..|...|..|..|. |.:.::.....|:...| |||..|
Human   263 VKEMIQHCVN----ANIDEAYKILAHLWHLGYSPEDII-GNIFRVCKTFQMAEYLK-LEFIKEIG 321

  Fly   318 YEH-RMQSGAKHIFHLEAFVAQ 338
            |.| ::..|...:..:...:|:
Human   322 YTHMKIAEGVNSLLQMAGLLAR 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RfC38	NP_001285833.1	rfc	3..345	CDD:234763	90/347 (26%)
RFC2	NP_852136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
RFC2	NP_852136.1	PLN03025	36..348	CDD:178596	90/347 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0470
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1071197at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820