DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csl4 and EXOSC1

DIOPT Version :9

Sequence 1:	NP_609492.1	Gene:	Csl4 / 34548	FlyBaseID:	FBgn0032346	Length:	204	Species:	Drosophila melanogaster
Sequence 2:	NP_057130.1	Gene:	EXOSC1 / 51013	HGNCID:	17286	Length:	195	Species:	Homo sapiens

Alignment Length:	189	Identity:	91/189 - (48%)
Similarity:	128/189 - (67%)	Gaps:	7/189 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CLPGERLCRTEDSIVLGIGTYEQNGYIYASKSGIVNIEDSGDKCQVVSVHKPGFHLTIPATGDVV 75
            |:||||||..|:... |.|||.::|||::|.:|.:..........||||.:......:|..|.:|
Human     8 CIPGERLCNLEEGSP-GSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIV 71

  Fly    76 TARVLVTTPKFAKCAIFCVRNVLLESSYRGLLRKEDVRETEKDRVDIYKSFRPGDVILARVIN-- 138
            |.:|.....:|||..|..|.::.|::|:||.:||||||.||||:|:|||||||||::||:||:
Human    72 TCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLG 136

  Fly   139 QLEQSFLLTTAENELGVVIAYASDYRKTRVPMVPVGWSEMQCPQTTIKEPRKVAKVLPE 197
            ..:.::||||||||||||:|::    ::.:.|||:.|.|||||:|..||.||||:|.||
Human   137 DAQSNYLLTTAENELGVVVAHS----ESGIQMVPISWCEMQCPKTHTKEFRKVARVQPE 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csl4	NP_609492.1	Csl4	10..193	CDD:224021	87/183 (48%)
		ECR1_N	10..47	CDD:291080	17/35 (49%)
		S1_CSL4	66..156	CDD:240217	48/91 (53%)
EXOSC1	NP_057130.1	ECR1_N	8..39	CDD:405131	16/31 (52%)
EXOSC1	NP_057130.1	S1_CSL4	62..154	CDD:240217	48/91 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152772
Domainoid	1	1.000	67	1.000	Domainoid score	I9888
eggNOG	1	0.900	-	-		E1_COG1096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9359
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4114
Isobase	1	0.950	-	0	Normalized mean entropy	S1914
OMA	1	1.010	-	-		QHG55393
OrthoDB	1	1.010	-	-		D1200489at2759
OrthoFinder	1	1.000	-	-		FOG0004386
OrthoInspector	1	1.000	-	-		oto91767
orthoMCL	1	0.900	-	-		OOG6_101821
Panther	1	1.100	-	-	LDO	PTHR12686
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R252
SonicParanoid	1	1.000	-	-		X4766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750