DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csl4 and exosc1

DIOPT Version :9

Sequence 1:	NP_609492.1	Gene:	Csl4 / 34548	FlyBaseID:	FBgn0032346	Length:	204	Species:	Drosophila melanogaster
Sequence 2:	NP_001123851.1	Gene:	exosc1 / 100170616	XenbaseID:	XB-GENE-1007857	Length:	194	Species:	Xenopus tropicalis

Alignment Length:	190	Identity:	92/190 - (48%)
Similarity:	131/190 - (68%)	Gaps:	9/190 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CLPGERLCRTEDSIVLGIGTYEQNGYIYASKSG-IVNIEDSGDKCQVVSVHKPGFHLTIPATGDV 74
            |:||||||.||| ...|.||:.::|||:||.:| ||...|:|....:..|.:...|| :|..|.|
Frog     7 CVPGERLCSTED-CAPGYGTFCRHGYIFASLAGYIVKKTDNGLMPVISVVRETDSHL-LPDVGSV 69

  Fly    75 VTARVLVTTPKFAKCAIFCVRNVLLESSYRGLLRKEDVRETEKDRVDIYKSFRPGDVILARVIN- 138
            ||.:|.....:|||..|..:.:..|.:::||.:||||:|.||||:|::||||||||:::|:||:
Frog    70 VTCKVTSINSRFAKVQIMYIGSTPLSNTFRGTIRKEDIRATEKDKVEVYKSFRPGDIVMAKVISL 134

  Fly   139 -QLEQSFLLTTAENELGVVIAYASDYRKTRVPMVPVGWSEMQCPQTTIKEPRKVAKVLPE 197
             .::.::||:|||||||||:|::    :....|||:.|.|||||:|.|||.||||:|.||
Frog   135 GDIQSNYLLSTAENELGVVVAHS----EAGATMVPISWCEMQCPKTHIKEQRKVARVQPE 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csl4	NP_609492.1	Csl4	10..193	CDD:224021	88/184 (48%)
		ECR1_N	10..47	CDD:291080	21/36 (58%)
		S1_CSL4	66..156	CDD:240217	44/91 (48%)
exosc1	NP_001123851.1	ECR1_N	7..40	CDD:379589	19/33 (58%)
exosc1	NP_001123851.1	S1_CSL4	61..153	CDD:240217	45/92 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9632
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9359
Inparanoid	1	1.050	171	0.133	Inparanoid score	I3985
OMA	1	1.010	-	-		QHG55393
OrthoDB	1	1.010	-	-		D1200489at2759
OrthoFinder	1	1.000	-	-		FOG0004386
OrthoInspector	1	1.000	-	-		oto105524
Panther	1	1.100	-	-	LDO	PTHR12686
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R252
SonicParanoid	1	1.000	-	-		X4766
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110