DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14921 and Tmtc4

DIOPT Version :9

Sequence 1:	NP_609491.1	Gene:	CG14921 / 34547	FlyBaseID:	FBgn0032345	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001347527.1	Gene:	Tmtc4 / 70551	MGIID:	1921050	Length:	741	Species:	Mus musculus

Alignment Length:	162	Identity:	35/162 - (21%)
Similarity:	59/162 - (36%)	Gaps:	40/162 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KISIELNRLVTR----KPDVVLLPQY-LKFNNPPIFFER--HLAQEIDEMASFCRIFKNEARIVL 69
            ::..:|||.|..    :...||.|:: |.:||..|..:.  :|||        ......|| :.|
Mouse   592 RLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQ--------AEAVGREA-LQL 647

  Fly    70 VKKEKGLWPEMFQKLDKEALMQKRLEIADLIVERNKKRDEKA---------LERYDNKRRAEIQK 125
            :..:..|   ||...:.....||..|...|.::..|.....|         ..|:.:...|:...
Mouse   648 IPNDHSL---MFSLANVLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHY 709

  Fly   126 EIQRETD------------MRERVKQFQENSV 145
            ||..:.|            :|.:::|.|:..|
Mouse   710 EISLQLDPVAVGTKENYSLLRRKLEQTQKKDV 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14921	NP_609491.1	p23_DYX1C1_like	4..81	CDD:107226	18/75 (24%)
Tmtc4	NP_001347527.1	DUF1736	292..366	CDD:369859
		TPR 1	448..481
		TPR	481..717	CDD:223533	30/136 (22%)
		TPR 2	482..515
		TPR repeat	482..510	CDD:276809
		TPR repeat	515..545	CDD:276809
		TPR 3	517..549
		TPR 4	550..583
		TPR repeat	550..578	CDD:276809
		TPR 5	584..617		7/24 (29%)
		TPR repeat	584..610	CDD:276809	4/17 (24%)
		TPR repeat	618..646	CDD:276809	9/36 (25%)
		TPR 6	619..651		10/40 (25%)
		TPR repeat	651..681	CDD:276809	7/32 (22%)
		TPR 7	652..685		8/35 (23%)
		TPR 8	686..719		6/32 (19%)
		TPR repeat	686..714	CDD:276809	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900