DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14921 and Dnaaf4

DIOPT Version :9

Sequence 1:NP_609491.1 Gene:CG14921 / 34547 FlyBaseID:FBgn0032345 Length:240 Species:Drosophila melanogaster
Sequence 2:NP_080590.3 Gene:Dnaaf4 / 67685 MGIID:1914935 Length:420 Species:Mus musculus


Alignment Length:261 Identity:72/261 - (27%)
Similarity:107/261 - (40%) Gaps:57/261 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 QTEEDIKISIELNRLVTRKPDVVLLPQYLKFNNPPIFFERHLAQEIDEMASFCRIFKNEARIVLV 70
            ||...|.:|:.|..:..|..||.....|||.|.||..||..|...||:..|..:|..:.....|.
Mouse    12 QTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLY 76

  Fly    71 KKEKGLW---------PEMFQKLDKEALMQ-------------------KRLEIADLI----VER 103
            |||..||         .||.|::.:::::|                   :|..:.:::    .||
Mouse    77 KKEPVLWDSLSVPGVDKEMMQRIREKSILQAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEER 141

  Fly   104 NKKRDEKALERYDNKRRAEIQKEIQRETDMRERVKQFQENSVREALVVDVRKEAKATPKPDTLQY 168
            .|..|.|..||.......|..||.|::.|.::||::.:     :.|.....:|.||. ||..|  
Mouse   142 KKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKE-----KPLEGKQAEETKAL-KPRGL-- 198

  Fly   169 PPSSGGASRLAT-----------PLMRPPMSSVRGSGRINVNFTTQHKRVTPK--RESQAAMEKA 220
             |.....:||.|           .|....:.:.|.:|.|.::||   .||.|.  ||||.|.|:.
Mouse   199 -PRKAPPTRLPTRGRNWENIFPEKLKEDRVPAPRSAGSIQISFT---PRVFPTALRESQVAEEEE 259

  Fly   221 Y 221
            :
Mouse   260 W 260

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14921NP_609491.1 p23_DYX1C1_like 4..81 CDD:107226 28/83 (34%)
Dnaaf4NP_080590.3 Mediates interaction with ESR1 and STUB1. /evidence=ECO:0000250 7..103 30/90 (33%)
p23_DYX1C1_like 10..87 CDD:107226 27/74 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..212 16/56 (29%)
TPR_11 287..351 CDD:290150
TPR 1 288..321
TPR repeat 288..316 CDD:276809
TPR repeat 321..351 CDD:276809
TPR 2 322..355
TPR_1 322..351 CDD:278916
TPR_12 324..396 CDD:290160
TPR repeat 362..392 CDD:276809
TPR 3 364..397
TPR_1 365..397 CDD:278916
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105298
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
65.670

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