DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14921 and IFIT2

DIOPT Version :9

Sequence 1:	NP_609491.1	Gene:	CG14921 / 34547	FlyBaseID:	FBgn0032345	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001538.4	Gene:	IFIT2 / 3433	HGNCID:	5409	Length:	472	Species:	Homo sapiens

Alignment Length:	159	Identity:	38/159 - (23%)
Similarity:	58/159 - (36%)	Gaps:	55/159 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EDIKISIELNRLVTRKPDVVLLPQYLKFNNPPIFFERHLAQEIDEMASFCRIFKNEARIVLVKKE 73
            :.::.:|.||      ||    .||||.         .||.::.:|                 :|
Human   196 DPLRQAIRLN------PD----NQYLKV---------LLALKLHKM-----------------RE 224

  Fly    74 KGLWPEMFQKLDKEALMQKRLEIADLIVERNK---KRDE---------KALERYDNKRRAEIQKE 126
            :|......:||.:||| :|...:.|::....|   ::||         ||||...|......|
Human   225 EGEEEGEGEKLVEEAL-EKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQ-- 286

  Fly   127 IQRETDMRERVKQFQENSVREALVVDVRK 155
                .....|.|.||..::||..:...||
Human   287 ----IGCCYRAKVFQVMNLRENGMYGKRK 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14921	NP_609491.1	p23_DYX1C1_like	4..81	CDD:107226	14/71 (20%)
IFIT2	NP_001538.4	TPR_12	51..112	CDD:290160
		TPR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	51..89
		TPR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	90..135
		TPR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	136..171
		TPR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	172..208		5/21 (24%)
		TPR repeat	208..236	CDD:276809	10/53 (19%)
		TPR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	247..280		8/32 (25%)
		TPR repeat	248..275	CDD:276809	6/26 (23%)
		TPR repeat	280..329	CDD:276809	9/38 (24%)
		TPR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	281..335		9/37 (24%)
		TPR repeat	334..359	CDD:276809
		TPR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	336..366
		TPR 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	367..405
		TPR 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	406..448
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900